Results 1 to 10 of about 27,933 (291)

Alphavirus Virulence Determinants [PDF]

Pathogens, 2021
Alphaviruses are important pathogens that continue to cause outbreaks of disease in humans and animals worldwide. Diseases caused by alphavirus infections include acute symptoms of fever, rash, and nausea as well as chronic arthritis and severe-to-fatal ...
Margarita V. Rangel, Kenneth A. Stapleford   +1 more
doaj   +4 more sources

A molecular understanding of alphavirus entry.

PLoS Pathogens, 2020
Alphaviruses cause severe human illnesses including persistent arthritis and fatal encephalitis. As alphavirus entry into target cells is the first step in infection, intensive research efforts have focused on elucidating aspects of this pathway ...
Autumn C Holmes, Katherine Basore, Daved H Fremont, Michael S Diamond   +3 more
doaj   +6 more sources

Arthritogenic Alphavirus Capsid Protein

Life, 2021
In the past two decades Old World and arthritogenic alphavirus have been responsible for epidemics of polyarthritis, causing high morbidity and becoming a major public health concern. The multifunctional arthritogenic alphavirus capsid protein is crucial
Shambhavi Rao, Adam Taylor
doaj   +5 more sources

Alphavirus Evasion of Zinc Finger Antiviral Protein (ZAP) Correlates with CpG Suppression in a Specific Viral nsP2 Gene Sequence

Viruses, 2023
Certain re-emerging alphaviruses, such as chikungunya virus (CHIKV), cause serious disease and widespread epidemics. To develop virus-specific therapies, it is critical to understand the determinants of alphavirus pathogenesis and virulence.
LeAnn P. Nguyen, Kelly S. Aldana, Emily Yang, Zhenlan Yao, Melody M. H. Li   +4 more
doaj   +2 more sources

Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Viruses, 2022
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko, Kai Rausalu, Sanjay Basu, Luke Alphey, Andres Merits   +4 more
doaj   +2 more sources

The Putative Roles and Functions of Indel, Repetition and Duplication Events in Alphavirus Non-Structural Protein 3 Hypervariable Domain (nsP3 HVD) in Evolution, Viability and Re-Emergence

Viruses, 2021
Alphavirus non-structural proteins 1–4 (nsP1, nsP2, nsP3, and nsP4) are known to be crucial for alphavirus RNA replication and translation. To date, nsP3 has been demonstrated to mediate many virus–host protein–protein interactions in several fundamental
Nurshariza Abdullah, Nafees Ahemad, Konstantinos Aliazis, Jasmine Elanie Khairat, Thong Chuan Lee, Siti Aisyah Abdul Ahmad, Nur Amelia Azreen Adnan, Nur Omar Macha, Sharifah Syed Hassan   +8 more
doaj   +2 more sources

Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing gn protects mice against Rift Valley fever virus. [PDF]

PLoS Neglected Tropical Diseases, 2010
Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas.
Nitin Bhardwaj, Mark T Heise, Ted M Ross
doaj   +7 more sources

Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation. [PDF]

PLoS Pathogens, 2015
The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic.
Suan-Sin Foo, Weiqiang Chen, Adam Taylor, Kuo-Ching Sheng, Xing Yu, Terk-Shin Teng, Patrick C Reading, Helen Blanchard, Cecilia Garlanda, Alberto Mantovani, Lisa F P Ng, Lara J Herrero, Suresh Mahalingam   +12 more
doaj   +6 more sources

Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner [PDF]

Frontiers in Immunology
IntroductionArthritogenic alphaviruses, including chikungunya (CHIKV) and Mayaro virus (MAYV), cause disease characterized by fever, rash, and incapacitating joint pain.
Muddassar Hameed, Muddassar Hameed, Muddassar Hameed, Pallavi Rai, Pallavi Rai, Md Shakhawat Hossain, Md Shakhawat Hossain, Andrea Daamen, Peter E. Lipsky, James Weger-Lucarelli, James Weger-Lucarelli   +10 more
doaj   +2 more sources

Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape

Microorganisms, 2021
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta, Rhonda Sin-Ling Chee, Lisa F.P. Ng   +2 more
doaj   +2 more sources