Results 91 to 100 of about 28,174 (288)

A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]

, 2017
Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel, Delgui, Laura Ruth   +1 more
core   +2 more sources

Cross-utilisation of template RNAs by alphavirus replicases

PLoS Pathogens, 2020
Most alphaviruses (family Togaviridae) including Sindbis virus (SINV) and other human pathogens, are transmitted by arthropods. The first open reading frame in their positive strand RNA genome encodes for the non-structural polyprotein, a precursor to ...
L. Lello, Age Utt, K. Bartholomeeusen, Sainan Wang, Kai Rausalu, Catherine Kendall, S. Coppens, R. Fragkoudis, A. Tuplin, L. Alphey, K. Ariën, A. Merits   +11 more
semanticscholar   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

In Vitro and In Vivo Phenotypes of Venezuelan, Eastern and Western Equine Encephalitis Viruses Derived from cDNA Clones of Human Isolates

Viruses, 2022
The Department of Defense recently began an effort to improve and standardize virus challenge materials and efficacy determination strategies for testing therapeutics and vaccines.
Christina L. Gardner, Chengqun Sun, Matthew D. Dunn, Theron C. Gilliland, Derek W. Trobaugh, Yutaka Terada, Douglas S. Reed, Amy L. Hartman, William B. Klimstra   +8 more
doaj   +1 more source

Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis. [PDF]

, 1998
Recent studies have established cell type- specific, proapoptotic, or antiapoptotic functions for the transcription factor NF-kappaB. In each of these studies, inhibitors of NF-kappaB activity have been present before the apoptotic stimulus, and so the ...
DiDonato, JA, Hardwick, JM, Hoffmann, A, Lin, KI, Ratan, RR   +4 more
core  

Outbreak of West Nile virus causing severe neurological involvement in children, Nuba Mountains, Sudan, 2002. [PDF]

, 2004
An atypical outbreak of West Nile virus (WNV) occurred in Ngorban County, South Kordophan, Sudan, from May to August 2002. We investigated the epidemic and conducted a case-control study in the village of Limon.
Anonymous (MMWR), Berthet FX, Chowers MY, George S, Hayes CG, Huang C, Hubalek Z, Kohler KA, Le Guenno B, Marberg K, McGuigan CC, McLean RG, Murgue B, Murgue B, Petersen LR, Petersen LR, Platonov AE, Solomon T, Taylor RM, Watts DM, Weinberger M   +20 more
core   +2 more sources

Quantitative trait loci and genes associated with salmonid alphavirus load in Atlantic salmon: implications for pancreas disease resistance and tolerance

Scientific Reports, 2020
Salmonid alphavirus infection results in pancreas disease causing severe economic losses for Atlantic salmon aquaculture. Knowledge about genes and pathways contributing to resistance is limited.
M. L. Aslam, D. Robledo, Aleksei Krasnov, H. Moghadam, B. Hillestad, R. Houston, M. Baranski, S. Boison, Nicholas Robinson   +8 more
semanticscholar   +1 more source

Amphibian Strategies Against Attacks by Flies: Host‐Specificity and Threats

Ecology and Evolution, Volume 16, Issue 1, January 2026.
Species interactions between Diptera flies and amphibians play a significant role in tropical ecosystems, but their ecology and evolution remain understudied. This review explores the costs flies impose on amphibians, such as pathogen transmission and disruption of communication systems, and highlights the evolutionary strategies employed by both ...
Leonardo Leite Ferraz de Campos, Luiz Carlos Pinho, Selvino Neckel‐Oliveira, Ximena E. Bernal   +3 more
wiley   +1 more source

Discovery of Mwinilunga alphavirus: A novel alphavirus in Culex mosquitoes in Zambia [PDF]

Virus Research, 2018
Mosquito-borne alphaviruses are disseminated globally and cause febrile illness in humans and animals. Since the prevalence and diversity of alphaviruses has not been previously investigated in Zambia, reverse transcription PCR was employed as a broad-spectrum approach for the detection of alphaviruses in mosquitoes.
Torii, Shiho, Orba, Yasuko, Hang'ombe, Bernard M., Mweene, Aaron S., Wada, Yuji, Anindita, Paulina D., Phongphaew, Wallaya, Qiu, Yongjin, Kajihara, Masahiro, Mori-Kajihara, Akina, Eto, Yoshiki, Harima, Hayato, Sasaki, Michihito, Carr, Michael, Hall, William W., Eshita, Yuki, Abe, Takashi, Sawa, Hirofumi   +17 more
openaire   +3 more sources

Phylogenetic and Timescale Analysis of Barmah Forest Virus as Inferred from Genome Sequence Analysis

Viruses, 2020
Barmah Forest virus (BFV) is a medically important mosquito-borne alphavirus endemic to Australia. Symptomatic disease can be a major cause of morbidity, associated with fever, rash, and debilitating arthralgia.
Alice Michie, Timo Ernst, I-Ly Joanna Chua, Michael D. A. Lindsay, Peter J. Neville, Jay Nicholson, Andrew Jardine, John S. Mackenzie, David W. Smith, Allison Imrie   +9 more
doaj   +1 more source