Results 11 to 20 of about 28,174 (288)

Alphavirus Virulence Determinants [PDF]

Pathogens, 2021
Alphaviruses are important pathogens that continue to cause outbreaks of disease in humans and animals worldwide. Diseases caused by alphavirus infections include acute symptoms of fever, rash, and nausea as well as chronic arthritis and severe-to-fatal ...
Margarita V. Rangel, Kenneth A. Stapleford   +1 more
doaj   +4 more sources

Plasmid DNA-based Alphavirus Vaccines [PDF]

Vaccines, 2019
Alphaviruses have been engineered as vectors for high-level transgene expression. Originally, alphavirus-based vectors were applied as recombinant replication-deficient particles, subjected to expression studies in mammalian and non-mammalian cell lines,
Kenneth Lundstrom
doaj   +5 more sources

Alphavirus-Based Vaccines [PDF]

Viruses, 2014
Alphavirus vectors have demonstrated high levels of transient heterologous gene expression both in vitro and in vivo and, therefore, possess attractive features for vaccine development.
Kenneth Lundstrom
doaj   +6 more sources

Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti-Alphavirus Therapies. [PDF]

Rev Med Virol
Alphaviruses are re‐emerging vector‐born pathogens that cause arthralgia or encephalitic diseases on a global scale. While a vaccine against chikungunya virus was recently approved, no vaccines currently exist for other alphaviruses, nor are there ...
Wang S, Mahalingam S, Merits A.
europepmc   +2 more sources

Salmonid alphavirus (SAV) [PDF]

Journal of Veterinary Research, 2018
Salmonid alphavirus (SAV), genus Alphavirus, family Togaviridae, is a single-stranded RNA virus affecting Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss). It is known to be responsible for pancreas disease (PD) and sleeping disease (
Deperasińska Izabela, Schulz Patrycja, Siwicki Andrzej K.   +2 more
doaj   +3 more sources

Granulocyte colony-stimulating factor protects against acute systemic alphavirus disease in a type I IFN-dependent manner [PDF]

Frontiers in Immunology
IntroductionArthritogenic alphaviruses, including chikungunya (CHIKV) and Mayaro virus (MAYV), cause disease characterized by fever, rash, and incapacitating joint pain.
Muddassar Hameed, Muddassar Hameed, Muddassar Hameed, Pallavi Rai, Pallavi Rai, Md Shakhawat Hossain, Md Shakhawat Hossain, Andrea Daamen, Peter E. Lipsky, James Weger-Lucarelli, James Weger-Lucarelli   +10 more
doaj   +2 more sources

Insights into Antibody-Mediated Alphavirus Immunity and Vaccine Development Landscape

Microorganisms, 2021
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate areas causing a wide range of symptoms ranging from inflammatory arthritis-like manifestations to the induction of encephalitis in humans.
Anthony Torres-Ruesta, Rhonda Sin-Ling Chee, Lisa F.P. Ng   +2 more
doaj   +2 more sources

Ly6C+ monocytes in the skin promote systemic alphavirus dissemination

Cell Reports
Summary: Alphaviruses are mosquito-transmitted pathogens that induce high levels of viremia, which facilitates dissemination and vector transmission. One prevailing paradigm is that, after skin inoculation, alphavirus-infected resident dendritic cells ...
Autumn C. Holmes, Cormac J. Lucas, Morgan E. Brisse, Brian C. Ware, Heather D. Hickman, Thomas E. Morrison, Michael S. Diamond   +6 more
doaj   +2 more sources

Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination

Cell Reports, 2023
Lily E. Adams, Sarah R. Leist, Kenneth H. Dinnon, Ande West, Kendra L. Gully, Elizabeth J. Anderson, Jennifer F. Loome, Emily A. Madden, John M. Powers, Alexandra Schäfer, Sanjay Sarkar, Izabella N. Castillo, Jenny S. Maron, Ryan P. McNamara, Harry L. Bertera, Mark R. Zweigert, Jaclyn S. Higgins, Brea K. Hampton, Lakshmanane Premkumar, Galit Alter, Stephanie A. Montgomery, Victoria K. Baxter, Mark T. Heise, Ralph S. Baric   +23 more
openalex   +2 more sources

Alphavirus [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources