Results 21 to 30 of about 27,933 (291)
Insights into the Landscape of Alphavirus Receptor and Antibody Interactions. [PDF]
VirusesPoudyal S, Bandyopadhyay A, Kuhn RJ.
europepmc +3 more sources
Entry receptors — the gateway to alphavirus infection
Journal of Clinical Investigation, 2023 Alphaviruses are enveloped, insect-transmitted, positive-sense RNA viruses that infect humans and other animals and cause a range of clinical manifestations, including arthritis, musculoskeletal disease, meningitis, encephalitis, and death. Over the past
O. Zimmerman +4 more
semanticscholar +1 more source
A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine [PDF]
Journal of Virology, 2013 ABSTRACTWhile a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever.
Anasuya, Chattopadhyay +4 more
openaire +2 more sources
Alphaviruses in Immunotherapy and Anticancer Therapy
Biomedicines, 2022 Alphaviruses have been engineered as expression vectors for vaccine development and gene therapy. Due to the feature of RNA self-replication, alphaviruses can provide exceptional direct cytoplasmic expression of transgenes based on the delivery of ...
Kenneth Lundstrom
doaj +1 more source
Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities. [PDF]
Adv Sci (Weinh)Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Casmil IC +12 more
europepmc +2 more sources
PLoS Pathogens, 2023 Chikungunya virus (CHIKV) is a reemerging alphavirus. Since 2005, it has infected millions of people during outbreaks in Africa, Asia, and South/Central America.
E. E. Treffers +6 more
semanticscholar +1 more source
Getah Virus (Alphavirus): An Emerging, Spreading Zoonotic Virus
Pathogens, 2022 Getah virus (GETV) is a zoonotic virus transmitted by mosquitoes, belonging to the Togaviridae family, Alphavirus genus. It was first isolated from mosquitoes in Malaysia in 1955, being widespread in island countries in the South Pacific region.
Bin Li, Huanyu Wang, G. Liang
semanticscholar +1 more source
Distinct Cellular Tropism and Immune Responses to Alphavirus Infection.
Annual Review of Immunology, 2022 Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalitis.
Natasha M. Kafai, M. Diamond, J. Fox
semanticscholar +1 more source
Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores
bioRxiv, 2022 Alphaviruses are emerging positive stranded RNA virus which replicate and transcribe their genomes in membranous organelles formed in the cell cytoplasm.
Rhian Jones +5 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Alphaviruses are mosquito-borne RNA viruses that cause rash, arthritis, and neurologic disease. Despite a continued risk of outbreaks, there are no licensed interventions for any alphavirus.
A. Jayabalan +7 more
semanticscholar +1 more source