Results 31 to 40 of about 28,174 (288)

A Chimeric Vesiculo/Alphavirus Is an Effective Alphavirus Vaccine [PDF]

Journal of Virology, 2013
ABSTRACTWhile a large number of mosquito-transmitted alphaviruses are known to cause serious human diseases, there are no licensed vaccines that protect against alphavirus infections. The alphavirus chikungunya virus (CHIKV) has caused multiple recent outbreaks of chikungunya fever.
Anasuya, Chattopadhyay, Eryu, Wang, Robert, Seymour, Scott C, Weaver, John K, Rose   +4 more
openaire   +2 more sources

Distinct Cellular Tropism and Immune Responses to Alphavirus Infection.

Annual Review of Immunology, 2022
Alphaviruses are emerging and reemerging viruses that cause disease syndromes ranging from incapacitating arthritis to potentially fatal encephalitis.
Natasha M. Kafai, M. Diamond, J. Fox
semanticscholar   +1 more source

Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores

bioRxiv, 2022
Alphaviruses are emerging positive stranded RNA virus which replicate and transcribe their genomes in membranous organelles formed in the cell cytoplasm.
Rhian Jones, Michael Homs, Nadia Rabat, Noelia Zamarreño, R. Arranz, J. Reguera   +5 more
semanticscholar   +1 more source

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

bioRxiv, 2021
Alphaviruses such as Ross River virus (RRV), chikungunya virus, Sindbis virus (SINV), and Venezuelan equine encephalitis virus are mosquito-borne pathogens that can cause arthritis or encephalitis diseases.
Yaw Bia Tan, L. Lello, Xin Liu, Y. Law, C. Kang, J. Lescar, Jie Zheng, A. Merits, D. Luo   +8 more
semanticscholar   +1 more source

Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus [PDF]

, 2018
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus ...
Aquilimeba, Muriel, Kasvandik, Sergo, Lulla, Aleksei, Lulla, Valeria, McInerney, Gerald M., Merits, Andres, Morro, Ainhoa Moliner, Mutso, Margit, Saul, Sirle, Smedberg, Cecilia, Tarve, Liisi, Teppor, Mona, Thaa, Bastian, Varjak, Margus   +13 more
core   +3 more sources

An alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

Science Translational Medicine, 2020
Replicating RNA vaccine delivered by lipid inorganic nanoparticles induces neutralizing antibody and T cells against SARS-CoV-2 in mice and macaques. A replicating RNA vaccine candidate to fight COVID-19 The COVID-19 pandemic caused by the coronavirus ...
Jesse H. Erasmus, Amit P. Khandhar, M. O’Connor, A. Walls, Emily A. Hemann, Patience Murapa, Jacob Archer, Shanna S. Leventhal, J. Fuller, Thomas B. Lewis, K. Draves, Samantha Randall, Kathryn A. Guerriero, M. Duthie, D. Carter, S. Reed, David W. Hawman, H. Feldmann, M. Gale, D. Veesler, P. Berglund, D. Fuller   +21 more
semanticscholar   +1 more source

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

Journal of Virology, 2021
A key element of every virus with an RNA genome is the RNA replicase. Understanding the principles of RNA replicase formation and functioning is therefore crucial for understanding and responding to the emergence of new viruses.
L. Lello, K. Bartholomeeusen, Sainan Wang, S. Coppens, R. Fragkoudis, L. Alphey, K. Ariën, A. Merits, Age Utt   +8 more
semanticscholar   +1 more source

Improved detection of genus-specific Alphavirus using a generic TaqMan® assay

BMC Microbiology, 2017
Background Alphaviruses are arthropod borne RNA viruses of medical importance. Geographical expansion of mosquitoes of the Aedes genus in the past decades has been associated with major Alphavirus-associated outbreaks. Climate changes and intensification
Claude Giry, Bénédicte Roquebert, Ghislaine Li-Pat-Yuen, Philippe Gasque, Marie-Christine Jaffar-Bandjee   +4 more
doaj   +1 more source

Alphavirus Identification in Neotropical Bats [PDF]

Viruses, 2022
Alphaviruses (Togaviridae) are arthropod-borne viruses responsible for several emerging diseases, maintained in nature through transmission between hematophagous arthropod vectors and susceptible vertebrate hosts. Although bats harbor many species of viruses, their role as reservoir hosts in emergent zoonoses has been verified only in a few cases. With
Lucía Moreira Marrero, Germán Botto Nuñez, Sandra Frabasile, Adriana Delfraro   +3 more
openaire   +4 more sources

Alphaviruses in Gene Therapy

Viruses, 2015
Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
doaj   +1 more source