Results 31 to 40 of about 27,933 (291)

Altered Spatial and Temporal Gait Parameters in Mice Infected with Ross River Virus

mSphere, 2021
Mouse models that accurately replicate the immunopathogenesis and clinical disease of alphavirus infection are vital to the preclinical development of therapeutic strategies that target alphavirus infection and disease.
Eranga Abeyratne, Ronak Reshamwala, Todd Shelper, Xiang Liu, Ali Zaid, Suresh Mahalingam, Adam Taylor   +6 more
doaj   +1 more source

Seroprevalence of alphavirus antibodies in a cross-sectional study in southwestern Tanzania suggests endemic circulation of chikungunya. [PDF]

PLoS Neglected Tropical Diseases, 2014
BACKGROUND: To date, Alphavirus infections and their most prominent member, chikungunya fever, a viral disease which first became apparent in Tanzania in 1953, have been very little investigated in regions without epidemic occurrence.
Nina Weller, Petra Clowes, Gerhard Dobler, Elmar Saathoff, Inge Kroidl, Nyanda Elias Ntinginya, Leonard Maboko, Thomas Löscher, Michael Hoelscher, Norbert Heinrich   +9 more
doaj   +1 more source

Discovery of Mwinilunga alphavirus: A novel alphavirus in Culex mosquitoes in Zambia [PDF]

Virus Research, 2018
Mosquito-borne alphaviruses are disseminated globally and cause febrile illness in humans and animals. Since the prevalence and diversity of alphaviruses has not been previously investigated in Zambia, reverse transcription PCR was employed as a broad-spectrum approach for the detection of alphaviruses in mosquitoes.
Torii, Shiho, Orba, Yasuko, Hang'ombe, Bernard M., Mweene, Aaron S., Wada, Yuji, Anindita, Paulina D., Phongphaew, Wallaya, Qiu, Yongjin, Kajihara, Masahiro, Mori-Kajihara, Akina, Eto, Yoshiki, Harima, Hayato, Sasaki, Michihito, Carr, Michael, Hall, William W., Eshita, Yuki, Abe, Takashi, Sawa, Hirofumi   +17 more
openaire   +3 more sources

Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold

bioRxiv, 2021
Alphaviruses such as Ross River virus (RRV), chikungunya virus, Sindbis virus (SINV), and Venezuelan equine encephalitis virus are mosquito-borne pathogens that can cause arthritis or encephalitis diseases.
Yaw Bia Tan, L. Lello, Xin Liu, Y. Law, C. Kang, J. Lescar, Jie Zheng, A. Merits, D. Luo   +8 more
semanticscholar   +1 more source

nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity

Journal of Virology, 2021
A key element of every virus with an RNA genome is the RNA replicase. Understanding the principles of RNA replicase formation and functioning is therefore crucial for understanding and responding to the emergence of new viruses.
L. Lello, K. Bartholomeeusen, Sainan Wang, S. Coppens, R. Fragkoudis, L. Alphey, K. Ariën, A. Merits, Age Utt   +8 more
semanticscholar   +1 more source

Alphavirus Identification in Neotropical Bats [PDF]

Viruses, 2022
Alphaviruses (Togaviridae) are arthropod-borne viruses responsible for several emerging diseases, maintained in nature through transmission between hematophagous arthropod vectors and susceptible vertebrate hosts. Although bats harbor many species of viruses, their role as reservoir hosts in emergent zoonoses has been verified only in a few cases. With
Lucía Moreira Marrero, Germán Botto Nuñez, Sandra Frabasile, Adriana Delfraro   +3 more
openaire   +4 more sources

Alphaviruses in Gene Therapy

Viruses, 2015
Alphavirus vectors present an attractive approach for gene therapy applications due to the rapid and simple recombinant virus particle production and their broad range of mammalian host cell transduction.
Kenneth Lundstrom
doaj   +1 more source

The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]

, 2016
Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S, Farzan, Michael, Gorman, Matthew J, Hyde, Jennifer L, Poddar, Subhajit   +4 more
core   +2 more sources

An alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

Science Translational Medicine, 2020
Replicating RNA vaccine delivered by lipid inorganic nanoparticles induces neutralizing antibody and T cells against SARS-CoV-2 in mice and macaques. A replicating RNA vaccine candidate to fight COVID-19 The COVID-19 pandemic caused by the coronavirus ...
Jesse H. Erasmus, Amit P. Khandhar, M. O’Connor, A. Walls, Emily A. Hemann, Patience Murapa, Jacob Archer, Shanna S. Leventhal, J. Fuller, Thomas B. Lewis, K. Draves, Samantha Randall, Kathryn A. Guerriero, M. Duthie, D. Carter, S. Reed, David W. Hawman, H. Feldmann, M. Gale, D. Veesler, P. Berglund, D. Fuller   +21 more
semanticscholar   +1 more source

Improved detection of genus-specific Alphavirus using a generic TaqMan® assay

BMC Microbiology, 2017
Background Alphaviruses are arthropod borne RNA viruses of medical importance. Geographical expansion of mosquitoes of the Aedes genus in the past decades has been associated with major Alphavirus-associated outbreaks. Climate changes and intensification
Claude Giry, Bénédicte Roquebert, Ghislaine Li-Pat-Yuen, Philippe Gasque, Marie-Christine Jaffar-Bandjee   +4 more
doaj   +1 more source