Results 51 to 60 of about 28,174 (288)

First Record of Mosquito-Borne Kyzylagach Virus in Central Europe

Viruses, 2020
RNA of Kyzylagach virus (KYZV), a Sindbis-like mosquito-borne alphavirus from Western equine encephalitis virus complex, was detected in four pools (out of 221 pools examined), encompassing 10,784 female Culex modestus mosquitoes collected at a fishpond ...
Silvie Šikutová, Patrik Dočkal, Petra Straková, Jan Mendel, Oldřich Šebesta, Lenka Betášová, Hana Blažejová, Zdeněk Hubálek, Ivo Rudolf   +8 more
doaj   +1 more source

The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]

, 2018
The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S, Klimstra, William B, Lucas, Tiffany M, Ryman, Kate D, Sun, Chengqun, Trobaugh, Derek W, Weiss, Christopher M   +6 more
core   +2 more sources

Interactions of Alphavirus nsP3 Protein with Host Proteins

Frontiers in Microbiology, 2018
Alphaviruses are members of the Togaviridae family and are grouped into two categories: arthritogenic and encephalitic. Arthritogenic alphavirus infections, as the name implies, are associated with arthritic outcomes while encephalitic alphavirus ...
Tyler Lark, Forrest Keck, Aarthi Narayanan   +2 more
doaj   +1 more source

Alphavirus Entry and Membrane Fusion [PDF]

Viruses, 2010
The study of enveloped animal viruses has greatly advanced our understanding of the general properties of membrane fusion and of the specific pathways that viruses use to infect the host cell. The membrane fusion proteins of the alphaviruses and flaviviruses have many similarities in structure and function.
Margaret Kielian, Chantal Chanel-Vos, Maofu Liao   +2 more
openaire   +3 more sources

Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture

Nature Communications
Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming.
Vasiliya Kril, M. Hons, Celine Amadori, Claire Zimberger, Laurine Couture, Yara Bouery, Julien Burlaud‐Gaillard, Andrei Karpov, Denis Ptchelkine, Alexandra L Thienel, B. Kümmerer, A. Desfosses, Rhian Jones, Philippe Roingeard, Laurent Meertens, Ali Amara, Juan Reguera   +16 more
semanticscholar   +1 more source

Dancing with the Devil: A Review of the Importance of Host RNA-Binding Proteins to Alphaviral RNAs during Infection

Viruses, 2023
Alphaviruses are arthropod-borne, single-stranded positive sense RNA viruses that rely on the engagement of host RNA-binding proteins to efficiently complete the viral lifecycle.
Claire E. Westcott, Cierra M. Isom, Deepa Karki, Kevin J. Sokoloski   +3 more
doaj   +1 more source

N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA

Journal of Virology
Epitranscriptomic RNA modifications can regulate the stability of mRNA and affect cellular and viral RNA functions. The N4-acetylcytidine (ac4C) modification in the RNA viral genome was recently found to promote viral replication; however, the mechanism ...
Yamei Dang, Jia Li, Yuchang Li, Yuan Wang, Yajing Zhao, Ningbo Zhao, Wanying Li, Hui Zhang, Chuantao Ye, Hongwei Ma, Liang Zhang, He Liu, Yangchao Dong, Min Yao, Y. Lei, Zhikai Xu, Fanglin Zhang, Wei Ye   +17 more
semanticscholar   +1 more source

Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA

Nature Communications, 2020
The alphavirus capsid protein (Cp) selectively packages genomic RNA (gRNA) into the viral nucleocapsid to produce infectious virus. Using photoactivatable ribonucleoside crosslinking and an innovative biotinylated Cp retrieval method, here we ...
Rebecca S. Brown, D. Anastasakis, M. Hafner, M. Kielian   +3 more
semanticscholar   +1 more source

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna, Liu, Jisheng, Smagghe, Guy, Swevers, Luc   +3 more
core   +1 more source

Arthritogenic Alphavirus Vaccines: Serogrouping Versus Cross-Protection in Mouse Models

Vaccines, 2020
Chikungunya virus (CHIKV), Ross River virus (RRV), o’nyong nyong virus (ONNV), Mayaro virus (MAYV) and Getah virus (GETV) represent arthritogenic alphaviruses belonging to the Semliki Forest virus antigenic complex. Antibodies raised against one of these
Wilson Nguyen, E. Nakayama, Kexin Yan, B. Tang, T. Le, Liang Liu, T. Cooper, J. Hayball, Helen M. Faddy, D. Warrilow, R. Allcock, J. Hobson-Peters, R. Hall, D. Rawle, V. Lutzky, P. Young, N. Oliveira, G. Hartel, P. Howley, N. Prow, A. Suhrbier   +20 more
semanticscholar   +1 more source