Results 61 to 70 of about 28,174 (288)

Alphavirus polymerase and RNA replication [PDF]

Virus Research, 2017
Alphaviruses are typically arthropod-borne, and many are important pathogens such as chikungunya virus. Alphaviruses encode four nonstructural proteins (nsP1-4), initially produced as a polyprotein P1234. nsP4 is the core RNA-dependent RNA polymerase but all four nsPs are required for RNA synthesis.
Maija K, Pietilä, Kirsi, Hellström, Tero, Ahola   +2 more
openaire   +2 more sources

Prevalence of Flavivirus and Alphavirus in bats captured in the state of Yucatan, southeastern Mexico

One Health
Summary: Flavivirus (family Flaviviridae) and Alphavirus (family Togaviridae) are mosquito-borne viruses that poses a significant risk to public health worldwide.
Aaron Yeh-Gorocica, Marco Torres-Castro, Claudia Carrillo-Chan, Alejandro Suarez-Galaz, Melissa Suarez-Galaz, Wilson Moguel-Chin, Alonso Panti-May, Cesar Lugo-Caballero, Henry Puerta-Guardo, Juan Chable-Santos, Pablo Manrique-Saide, Guadalupe Ayora-Talavera, Celia Selem-Salas, Mario Frias-Casas, Antonio Rivero-Juarez   +14 more
doaj   +1 more source

Why enveloped viruses need cores -- the contribution of a nucleocapsid core to viral budding

, 2017
During the alphavirus lifecycle, a nucleocapsid core buds through the cell membrane to acquire an outer envelope of lipid membrane and viral glycoproteins. However, the presence of a nucleocapsid core is not required for assembly of infectious particles.
Hagan, Michael F., Lazaro, Guillermo R., Mukhopadhyay, Suchetana   +2 more
core   +1 more source

Mannose binding lectin is required for alphavirus-induced arthritis/myositis [PDF]

, 2015
Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis.
Blevins, Lance K., Fraser, Robert J., Gunn, Bronwyn M., Heise, Mark T., Herrero, Lara J., Hueston, Linda, Mahalingam, Suresh, Morrison, Thomas E., Ramirez, Ruben, Smith, Paul N., Whitmore, Alan C.   +10 more
core   +1 more source

Mayaro Virus: An Emerging Alphavirus in the Americas

Viruses
Mayaro virus (MAYV) is an arbovirus first isolated in Trinidad and Tobago in 1954. MAYV is the causative agent of Mayaro fever, which is characterised by high fever, maculopapular rash, myalgia and arthralgia.
Lily Li Lin Wei, Rufaro Tom, Young Chan Kim   +2 more
semanticscholar   +1 more source

Virome Identification and Characterization of Fusarium sacchari and F. andiyazi: Causative Agents of Pokkah Boeng Disease in Sugarcane

Frontiers in Microbiology, 2020
Fusarium sacchari and Fusarium andiyazi are two devastating sugarcane pathogens that cause pokkah boeng disease (PBD) in China. RNA_Seq was conducted to identify mycoviruses in F. sacchari and F.
Ziting Yao, Ziting Yao, Chengwu Zou, Chengwu Zou, Na Peng, Na Peng, Yu Zhu, Yixue Bao, Yixue Bao, Qiujuan Zhou, Qiujuan Zhou, Qingfa Wu, Baoshan Chen, Baoshan Chen, Muqing Zhang, Muqing Zhang   +15 more
doaj   +1 more source

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice

mBio, 2020
Viral encephalomyelitis is an important cause of long-term disability, as well as acute fatal disease. Identifying viral determinants of outcome helps in assessing disease severity and developing new treatments. Mosquito-borne alphaviruses infect neurons
Rachy Abraham, R. McPherson, Morgan Dasovich, M. Badiee, A. Leung, D. Griffin   +5 more
semanticscholar   +1 more source

Specific Recognition of a Stem-Loop RNA Structure by the Alphavirus Capsid Protein

Viruses, 2021
Alphaviruses are small enveloped viruses with positive-sense RNA genomes. During infection, the alphavirus capsid protein (Cp) selectively packages and assembles with the viral genomic RNA to form the nucleocapsid core, a process critical to the ...
Rebecca S. Brown, Lisa M Kim, M. Kielian
semanticscholar   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Mutations in the E2 glycoprotein and the 3\u27 untranslated region enhance chikungunya virus virulence in mice [PDF]

, 2017
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain and inflammation and can persist for months to years after acute infection.
Carpentier, Kathryn S, Diamond, Michael S, Fox, Julie M, Hawman, David W, May, Nicholas A, Montgomery, Stephanie A, Moorman, Nathaniel J, Morrison, Thomas E, Sanders, Wes   +8 more
core   +3 more sources