Results 101 to 110 of about 3,257,979 (198)

Controlled Field Trial of Pancreas Disease Vaccines in Farmed Atlantic Salmon: Effects on Growth and Mortality During a SAV2 Outbreak

Journal of Fish Diseases, Volume 48, Issue 12, December 2025.
ABSTRACT Pancreas disease (PD), caused by salmonid alphavirus (SAV), is a concern for salmon aquaculture in Scotland, Ireland and Norway. This article presents results from a controlled field trial monitoring three study groups from vaccination to harvest.
Jostein Mulder Pettersen, Marte Follesø Sønnervik, Marius Karlsen, Hege Jørstad Sekkenes, Geir Schriwer, Petter Gjesdal, Ane Sandtrø, Magnus Vikan Røsæg   +7 more
wiley   +1 more source

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source

Chronic alphavirus infection of L cells.

Acta virologica, 1981
Chronic infection of L cells with Sindbis virus, induced in the absence of antiviral antibody, was studied by virological methods in combination with light and electron microscopy. Both Sindbis virus and endogenous oncovirus antigens were revealed in the cells by immunofluorescence.
T A, Ivannikova, , Karmysheva VYa, N V, Ovsyannikova, L M, Farutina   +3 more
openaire   +1 more source

Advances in Viroporin Function and Structure: A Comparative Analysis of Alphavirus 6K with Well-Characterized Viroporins

Viruses
Viruses encode ion channel proteins called viroporins to assist in infection and immune evasion. The alphavirus 6K protein is classified as a member of the viroporin family of proteins.
Vashi Negi, Andrew S. Miller, Richard J. Kuhn   +2 more
doaj   +1 more source

Encephalitis associated with the chikungunya epidemic outbreak in Brazil: report of 2 cases with neuroimaging findings

Revista da Sociedade Brasileira de Medicina Tropical
Chikungunya, an alphavirus infection presenting with fever, rash, and polyarthritis, is most often an acute febrile illness. Neurologic complications of chikungunya infection have been reported.
Licia Pacheco Pereira, Rafaela Villas-Bôas, Stephanie Suzanne de Oliveira Scott, Paulo Ribeiro Nóbrega, Manoel Alves Sobreira-Neto, José Daniel Vieira de Castro, Bruno Cavalcante, Pedro Braga-Neto   +7 more
doaj   +1 more source

Synthesis of cellulose nanocrystals carrying tyrosine sulfate mimetic ligands and inhibition of alphavirus infection.

Biomacromolecules, 2014
We present two facile approaches for introducing multivalent displays of tyrosine sulfate mimetic ligands on the surface of cellulose nanocrystals (CNCs) for application as viral inhibitors.
J. Zoppe, Ville Ruottinen, Janne Ruotsalainen, S. Rönkkö, Leena‐Sisko Johansson, A. Hinkkanen, K. Järvinen, J. Seppälä   +7 more
semanticscholar   +1 more source

Identification of differentially expressed Atlantic salmon miRNAs responding to salmonid alphavirus (SAV) infection

BMC Genomics, 2017
BackgroundMicroRNAs (miRNAs) control multiple biological processes including the innate immune responses by negative post-transcriptional regulation of gene expression.
R. Andreassen, N. T. Woldemariam, Ine Østråt Egeland, O. Agafonov, H. Sindre, B. Høyheim   +5 more
semanticscholar   +1 more source

A cross-reactive antibody protects against Ross River virus musculoskeletal disease despite rapid neutralization escape in mice.

PLoS Pathogens, 2020
Arthritogenic alphaviruses cause debilitating musculoskeletal disease and historically have circulated in distinct regions. With the global spread of chikungunya virus (CHIKV), there now is more geographic overlap, which could result in heterologous ...
Julie M Fox, Ling Huang, Stephen Tahan, Laura A Powell, James E Crowe, David Wang, Michael S Diamond   +6 more
doaj   +1 more source

Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquito Aedes aegypti. [PDF]

Proc Natl Acad Sci U S A, 2023
Reitmayer CM, Levitt E, Basu S, Atkinson B, Fragkoudis R, Merits A, Lumley S, Larner W, Diaz AV, Rooney S, Thomas CJE, von Wyschetzki K, Rausalu K, Alphey L.   +13 more
europepmc   +1 more source

Chikungunya Vaccine Candidates: Current Landscape and Future Prospects

Drug Design, Development and Therapy, 2022
Christin Schmidt, Barbara S Schnierle Paul-Ehrlich-Institut, Department of Virology, Section AIDS and Newly Emerging Pathogens, Langen, GermanyCorrespondence: Barbara S Schnierle, Paul-Ehrlich-Institut, Department of Virology, Section AIDS and newly ...
Schmidt C, Schnierle BS
doaj