Results 101 to 110 of about 17,945 (225)

Alphavirus nsP3 organizes into tubular scaffolds essential for infection and the cytoplasmic granule architecture

open access: yesNature Communications
Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming.
Vasiliya Kril   +16 more
doaj   +1 more source

Mapping of RNA- temperature-sensitive mutants of Sindbis virus: assignment of complementation groups A, B, and G to nonstructural proteins [PDF]

open access: yes, 1989
Four complementation groups of temperature-sensitive (ts) mutants of Sindbis virus that fail to make RNA at the nonpermissive temperature are known, and we have previously shown that group F mutants have defects in nsP4.
Hahn, Young S.   +2 more
core   +1 more source

The growth of arthralgic Ross River virus is restricted in human monocytic cells [PDF]

open access: yes, 2016
International audienceAlphaviruses such as Chikungunya and Ross River (RRV) viruses are associated with persistent arthritisand arthralgia in humans. Monocytes and macrophages are believed to play an important role in alphaviralarthritides. In this study,
Belarbi, Essia   +7 more
core   +2 more sources

A Pyrido‐Quinoxaline Derivative That Downregulates Reticulon 3 Protein Exhibits Potent Antiviral Activity Against Zika Virus

open access: yesJournal of Medical Virology, Volume 97, Issue 9, September 2025.
ABSTRACT In the wake of the COVID‐19 pandemic, awareness of emerging pathogens has significantly increased, prompting greater investment in research and preparedness. In this context, arboviral diseases are recognized as unmet medical challenges due to their rapid spread. Notably, the geographical range of several flaviviral diseases is expanding: Zika
Erika Plicanti   +11 more
wiley   +1 more source

The Role of the Deubiquitylase UCHL3 During Alphavirus Infection [PDF]

open access: yes, 2018
Alphaviruses are positive-sense RNA viruses from the family Togaviridae. These viruses rely on arthropod vectors, such as mosquitos, to replicate before transmission to vertebrates. There are several medically important viruses in this group, including Chikungunya virus (CHIKV) which, since 2004, has caused large number of epidemics that have infected ...
openaire   +2 more sources

Diversity in viral anti-PKR mechanisms: A remarkable case of evolutionary convergence [PDF]

open access: yes, 2015
Most viruses express during infection products that prevent or neutralize the effect of the host dsRNA activated protein kinase (PKR). Translation of Sindbis virus (SINV) mRNA escapes to PKR activation and eIF2 phosphorylation in infected cells by a ...
Domingo-Gil, Elena   +4 more
core   +1 more source

The Role of the Deubiquitylase MYSM1 During Alphavirus Infection [PDF]

open access: yes, 2017
The Role of the Deubiquitylase MYSM1 During Alphavirus Infection Amer Nubgan The members of the genus Alphavirus are positive-sense RNA viruses and it is one of two within the family Togaviridae. Most alphaviruses are predominantly transmitted to susceptible vertebrates by a mosquito vector.
openaire   +2 more sources

A Viral mRNA Motif at the 3′-Untranslated Region that Confers Translatability in a Cell-Specific Manner. Implications for Virus Evolution [PDF]

open access: yes, 2016
Sindbis virus (SINV) mRNAs contain several motifs that participate in the regulation of their translation. We have discovered a motif at the 3′ untranslated region (UTR) of viral mRNAs, constituted by three repeated sequences, which is involved in the ...
Carrasco, Luis   +2 more
core   +2 more sources

Characteristics of Madariaga and Venezuelan Equine Encephalitis Virus Infections, Panama

open access: yesEmerging Infectious Diseases
Madariaga virus (MADV) and Venezuelan equine encephalitis virus (VEEV) are emerging arboviruses affecting rural and remote areas of Latin America. However, clinical and epidemiologic reports are limited, and outbreaks are occurring at an increasing ...
Luis Felipe Rivera   +24 more
doaj   +1 more source

Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health

open access: yesMicrobial Biotechnology, Volume 18, Issue 9, September 2025.
Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley   +1 more source

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