Results 131 to 140 of about 12,699 (245)

Alphavirus Genome Structure and Replication [PDF]

, 2016
The family Togaviridae consists of two genera, Alphavirus and Rubivirus (Fields et al., 2013). The organization of their respective genomes is similar, but phylogenetic analysis shows that alphaviruses and rubiviruses are quite divergent (Koonin and ...
Belinda L. Herring, Rulli, Nestor E, Mahalingam, Suresh, Chen, Weiqiang, Herring, Belinda L, Lara J. Herrero, Weiqiang Chen, Kuo-Ching Sheng, Nestor E. Rulli, Suresh Mahalingam, Herrero, Lara J, Sheng, Kuo-Ching   +11 more
core   +1 more source

Exposure to non-endemic arboviruses (alphaviruses) in Costa Rica assessed from human samples collected in areas with contrasting levels of dengue endemicity

Frontiers in Public Health
Arboviruses represent a global public health challenge. The lack of diagnostic protocols and the presence of asymptomatic infections complicate confirmatory diagnostics.
Andrea Valles-Morera, Tatiana Murillo, Jose Lizano-Bolaños, Sergio Gutierrez-Roche, Margarita Alvarado, Jonathan Alfaro-Alvarado, Gerardo Andrés Calvo-Salas, Grace Prado-Hidalgo, Johis Ortega, Eugenia Corrales-Aguilar   +9 more
doaj   +1 more source

Experimental Infection of Potential Reservoir Hosts with Venezuelan Equine Encephalitis Virus, Mexico

Emerging Infectious Diseases, 2009
In 1993, an outbreak of encephalitis among 125 affected equids in coastal Chiapas, Mexico, resulted in a 50% case-fatality rate. The outbreak was attributed to Venezuelan equine encephalitis virus (VEEV) subtype IE, not previously associated with equine ...
Eleanor R. Deardorff, Naomi L. Forrester, Amelia P. Travassos da Rosa, Jose G. Estrada-Franco, Roberto Navarro-Lopez, Robert B. Tesh, Nikos Vasilakis   +6 more
doaj   +1 more source

Current Understanding of the Role of Cholesterol in the Life Cycle of Alphaviruses

, 2020
Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are part of the Togaviridae family ...
Andre M. O. Gomes, Ivanildo P. Sousa, Carlos A. M. Carvalho, Gomes, Andre M. O., Carvalho, Carlos A. M., Sousa Jr, Ivanildo P.   +5 more
core   +1 more source

Cross-reactivity among alphaviruses provides insight into viral emergence and novel defense strategies

, 2022
Alphaviruses are a group of medically relevant arthropod-borne viruses (arboviruses) belonging to the Togaviridae family that are maintained by mosquito vectors.
Webb, Emily Morgan
core  

Recombinant alphaviruses as vectors for anti-tumour and anti-microbial immunotherapy

, 2006
Background: Vectors derived from alphaviruses are gaining interest for their high transfection potency and strong immunogenicity. Objectives: After a brief introduction on alphaviruses and their vectors, an overview is given on current preclinical ...
Daemen, T; id_orcid, Bungener, L, Wischut, J, Daemen, T, de Mare, A, Huckriede, A, Riezebos-Brilman, A   +6 more
core   +1 more source

Mosquito-borne alphaviruses in Zambia: Isolation and characterization of Eilat and Sindbis viruses

Virus Research
Alphaviruses in the family Togaviridae include zoonotic arthropod-borne viruses, including Sindbis virus (SINV), chikungunya virus, as well as insect-specific viruses such as Eilat virus (EILV).
Chadwic De’Sean Mears, Koshiro Tabata, Takuma Ariizumi, Bernard M. Hang'ombe, Yongjin Qiu, Hayato Harima, Masahiro Kajihara, William W. Hall, Michihito Sasaki, Hirofumi Sawa, Yasuko Orba   +10 more
doaj   +1 more source

How alphaviruses cause disease and identifying new therapeutics.

Alphaviruses are transmitted by mosquitoes and cause a variety of serious human infections. This project investigates how alphaviruses cause disease, with special focus on inflammatory musculoskeletal diseases.

core  

TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.

PLoS Pathogens
Alphaviruses are mosquito borne RNA viruses that are a reemerging public health threat. Alphaviruses have a broad host range, and can cause diverse disease outcomes like arthritis, and encephalitis.
Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan   +9 more
doaj   +1 more source

Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection

Vaccines
Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use.
Whitney C. Weber, Takeshi F. Andoh, Craig N. Kreklywich, Zachary J. Streblow, Michael Denton, Magdalene M. Streblow, John M. Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T. Curiel, Nicole N. Haese, Daniel N. Streblow   +12 more
doaj   +1 more source