Results 241 to 250 of about 129,945 (312)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

ITCH regulates Golgi integrity and proteotoxicity in neurodegeneration. [PDF]

Sci Adv
Xiang Q, Lu Y, Wang H, Chen H, Chen P, Zhao X, Cortes Morales L, Yang Y, Yang J, Zhang T, Wang J.   +10 more
europepmc   +1 more source

[New results from the RABBIT register on the cancer risk of patients with rheumatoid arthritis treated with Janus kinase inhibitors]. [PDF]

Z Rheumatol
Schäfer M, Strangfeld A.
europepmc   +1 more source

[Systemic sclerosis : A disease with multiple faces]. [PDF]

Dermatologie (Heidelb)
Evers C, Distler J, Distler O.
europepmc   +1 more source

Unveiling the Genetic Association Between Hemoglobin Concentration and Amyotrophic Lateral Sclerosis. [PDF]

Brain Behav
Luo H, Yang Y, Cao X, Deng C, Chen H.
europepmc   +1 more source

The Molecular Architecture of Neurodegeneration: An Integrative Overview of Convergent Mechanisms. [PDF]

NeuroSci
Aranda-Abreu GE, Rojas-Durán F, Hernández-Aguilar ME, Herrera-Covarrubias D, Tlapa-Monge LR, Mestizo-Gutiérrez SL.   +5 more
europepmc   +1 more source

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD. [PDF]

Front Mol Neurosci
Kim SH, Boos CE, Scalf M, Wilkemeyer AK, Smith LM, Tibbetts RS.   +5 more
europepmc   +1 more source