Results 71 to 80 of about 331,356 (244)

Methylprednisolone inhibits the alternative and amplification pathways of complement [PDF]

Infection and Immunity, 1982
Methylprednisolone sodium succinate limited the ability of zymosan or lipopolysaccharide to activate complement in normal serum by the alternative amplification pathways. Methylprednisolone limited B consumption in a reaction mixture which contained purified C3b, D, and B, indicating that soluble steroid directly inhibited the amplification pathway ...
J M Weiler, B D Packard
openaire   +3 more sources

Activation of the alternative complement pathway by Sporothrix schenckii [PDF]

Infection and Immunity, 1986
We studied the activation of complement by Sporothrix schenckii yeast cells. Total complement activity, and the effect of various activators on this activity, were assayed on aliquots of fresh nonimmune human serum with and without prior treatment with chelators.
H G Muchmore, E N Scott, D P Fine
openaire   +3 more sources

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

Activation of the Alternative Complement Pathway by Fungal Melanins [PDF]

Clinical and Vaccine Immunology, 2002
ABSTRACTMelanins are complex biological pigments formed by the oxidative polymerization of phenolic and/or indolic compounds. These pigments have been implicated in the pathogenesis of some microbial infections, malignancies, degenerative disorders, and autoimmune diseases.
Ángel L. Rosas, T. R. Kozel, J. D. Nosanchuk, J. D. Nosanchuk, R. S. MacGill, Arturo Casadevall, Arturo Casadevall   +6 more
openaire   +3 more sources

A C3(H20) recycling pathway is a component of the intracellular complement system [PDF]

, 2017
An intracellular complement system (ICS) has recently been described in immune and nonimmune human cells. This system can be activated in a convertase-independent manner from intracellular stores of the complement component C3. The source of these stores
Botto, Bu, Hrishikesh S. Kulkarni, John P. Atkinson, Liszewski, M. Kathryn Liszewski, Michelle Elvington, Nickells, Paula Bertram, Seya, Singer, Vĕtvicka   +11 more
core   +2 more sources

C3 glomerulopathy: a kidney disease mediated by alternative pathway deregulation

Frontiers in Nephrology
C3 glomerulopathy (C3G) is an ultra-rare complement-mediated kidney disease caused by to the deregulation of the alternative pathway (AP) of proximal complement.
Karin Heidenreich, Deepti Goel, P. S. Priyamvada, Sagar Kulkarni, Vipul Chakurkar, Dinesh Khullar, Ravi Singh, Charan Bale, Peter F. Zipfel   +8 more
doaj   +1 more source

Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region [PDF]

, 2017
The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases.
De Pablos, Luis Miguel, Díaz Lozano, Isabel María, Longhi, Silvia Andrea, Osuna, Antonio, Schijman, Alejandro Gabriel, Zago, María Paola   +5 more
core   +3 more sources

Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? [PDF]

, 2011
BackgroundAnorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a new sensitive biomarker.
Flierl, Michael A, Gaudiani, Jennifer L, Long, Carlin S, Mehler, Philip S, Sabel, Allison L, Stahel, Philip F   +5 more
core   +2 more sources

Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen

Immunobiology
An over-active alternative complement pathway has been implicated in the pathophysiology of multiple diseases, including IgA nephropathy and geographic atrophy secondary to age related macular degeneration.
Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice   +10 more
doaj   +1 more source

Kidney Diseases Caused by Complement Dysregulation: Acquired, Inherited, and Still More to Come

Clinical and Developmental Immunology, 2012
Inherited and acquired dysregulation of the complement alternative pathway plays an important role in multiple renal diseases. In recent years, the identification of disease-causing mutations and genetic variants in complement regulatory proteins has ...
Saskia F. Heeringa, Clemens D. Cohen
doaj   +1 more source