Results 71 to 80 of about 433,637 (362)
PLoS ONE, 2019 Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), are autoimmune conditions associated with small vessel inflammation.
Sophie Ohlsson +6 more
doaj +1 more source
Autoantibodies against alternative complement pathway proteins in renal pathologies
Nefrología (English Edition), 2016 Complement system activation plays an important role in several renal pathologies, including antibody-mediated glomerulonephritis, ischaemia–reperfusion injury of transplanted kidneys or renal allograft rejection.
Pilar Nozal, Margarita López-Trascasa
doaj +1 more source
Dispensability of Escherichia coli's latent pathways [PDF]
Proc. Natl. Acad. Sci. USA 108, 3124-3129 (2011), 2011 Gene-knockout experiments on single-cell organisms have established that expression of a substantial fraction of genes is not needed for optimal growth. This problem acquired a new dimension with the recent discovery that environmental and genetic perturbations of the bacterium Escherichia coli are followed by the temporary activation of a large number
arxiv +1 more source
Activation of the alternative complement pathway by Trichomonas vaginalis [PDF]
Infection and Immunity, 1981 The mechanism underlying the lysis of Trichomonas vaginalis by normal human or guinea pig serum was investigated. The involvement of the complement system was demonstrated by the failure of human serum deficient in C3 or C8 to mediate parasite killing and by the ablation of lytic activity observed when fresh sera were heated at 56 degrees C or treated ...
A Sher, Frances D. Gillin
openaire +3 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
A Comparison of the Pathway Tools Software with the Reactome Software [PDF]
arXiv, 2020 This document compares SRI's Pathway Tools (PTools) software with the Reactome software. Both software systems serve the pathway bioinformatics area, including representation and analysis of metabolic pathways and signaling pathways. The comparison covers pathway bioinformatics capabilities, but does not cover other major facets of Pathway Tools that ...
arxiv
Protein load impairs factor H binding promoting complement-dependent dysfunction of proximal tubular cells [PDF]
, 2009 Intrarenal complement activation plays an important role in the progression of chronic kidney disease. A key target of the activated complement cascade is the proximal tubule, a site where abnormally filtered plasma proteins and complement factors ...
Abbate, Mauro +9 more
core +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
The Group Structure of Pivot and Loop Complementation on Graphs and Set Systems [PDF]
European Journal of Combinatorics, v. 32, 1353-1367, 2011, 2009 We study the interplay between principal pivot transform (pivot) and loop complementation for graphs. This is done by generalizing loop complementation (in addition to pivot) to set systems. We show that the operations together, when restricted to single vertices, form the permutation group S_3.
arxiv +1 more source
Activation of the Alternative Complement Pathway by Fonsecaea pedrosoi
Journal of Investigative Dermatology, 1984 Human sera were examined for evidence of complement activation by Fonsecaea pedrosoi. The serum that had been incubated with F. pedrosoi showed immunoelectrophoretic C3 conversion and generation of C5a, as measured by radioimmunoassay. C3 conversion and C5a generation did not occur in serum chelated with EDTA, or in serum heated to 56 degrees C for 30 ...
Hachiro Tagami +3 more
openaire +3 more sources