Results 1 to 10 of about 2,301,526 (265)

Scientific Opinion on Isolation in proofed pit on‐farm of dead poultry

EFSA Journal, 2011
EFSA's Scientific Panel on Biological Hazards (BIOHAZ) was asked for a scientific opinion on an alternative method for processing Category (Cat) 2 Animal By‐Products (ABP) as defined in Reg. (EC) 1069/2009.
EFSA Panel on Biological Hazards (BIOHAZ)
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Ethics for the Living World Alternative Methods and New Strategies for The Protection of Nonhuman Animals

Relations, 2013
The use of animals in laboratories is a controversial issue involving much dispute between the researchers who support animal experimentation and those who are in favor of its abolishment.
Susanna Penco, Rosagemma Ciliberti
doaj   +1 more source

Perspectives on variability of in vivo toxicology studies: considerations for next-generation toxicology

Frontiers in Toxicology
IntroductionAnimal studies have historically informed toxicological testing and safety assessments. However, assessment of the variability in both quantitative and qualitative results has been limited.
Agnes L. Karmaus, Anna L. Kreutz, Oluwakemi Oyetade, Katie Paul Friedman, Martin Paparella, Emily N. Reinke, David Allen, Helena T. Hogberg, Nicole C. Kleinstreuer   +8 more
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A Novel Machine Learning Model and a Web Portal for Predicting the Human Skin Sensitization Effects of Chemical Agents

Toxics
Skin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating a need for reliable in ...
Ricardo Scheufen Tieghi, José Teófilo Moreira-Filho, Holli-Joi Martin, James Wellnitz, Miguel Canamary Otoch, Marielle Rath, Alexander Tropsha, Eugene N. Muratov, Nicole Kleinstreuer   +8 more
doaj   +1 more source

Scientific Opinion on Bioreduction application

EFSA Journal, 2013
A method for on‐farm containment of animal by‐products (ABPs), called a ‘Bioreduction’ system, was assessed. The material for containment is of ovine origin and classified as a Category (Cat.) 1 ABP material.
EFSA Panel on Biological Hazards (BIOHAZ)
doaj   +1 more source

Implementation of the 3Rs Concept in Quality Control of Biologicals: Status and Prospects (Review)

Безопасность и риск фармакотерапии
INTRODUCTION. Many countries are implementing an increasing number of alternatives to animal testing in the research, development, and quality control of medicines under the concept of 3Rs (replacement, reduction, and refinement).
L. A. Gaiderova, N. A. Alpatova, O. V. Golovinskaya, A. M. Guskov, E. K. Lipatova, M. N. Lavrova   +5 more
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An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate

Frontiers in Toxicology
Di(ethylhexyl) phthalate (DEHP) is a ubiquitous environmental contaminant to which humans are exposed via multiple routes. Human health risk assessments for this substance have recently been updated, focusing on reproductive toxicity, including DEHP, in ...
Gelsomina Pillo, Gelsomina Pillo, Federico Aldrovandi, Federico Aldrovandi, Ada Mescoli, Giangabriele Maffei, Giangabriele Maffei, Maria Grazia Mascolo, Monica Vaccari, Annamaria Colacci, Annamaria Colacci   +10 more
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The Use of Different Hot Foam Doses for Weed Control

Agronomy, 2019
Thermal weed control technology plays an important role in managing weeds in synthetic herbicide-free systems, particularly in organic agriculture. The use of hot foam represents an evolution of the hot water weed control thermal method, modified by the ...
Luisa Martelloni, Christian Frasconi, Mino Sportelli, Marco Fontanelli, Michele Raffaelli, Andrea Peruzzi   +5 more
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Scientific Opinion on the ‘Biomation’ application for an alternative method for the treatment of animal‐by‐products

EFSA Journal, 2012
A method alternative to the ones already approved in the current legislation, called ‘Biomation’ process, for the treatment of Category (Cat.) 2 and 3 Animal By‐Products (ABP) was assessed. The process consists of an alkaline treatment.
EFSA Panel on Biological Hazards (BIOHAZ)
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Evaluation of the Safety of Cosmetic Ingredients and Their Skin Compatibility through In Silico and In Vivo Assessments of a Newly Developed Eye Serum

Toxics
The term “risk assessment” is often substituted with “safety assessment”, to demonstrate the safe properties of cosmetic ingredients and formulations. With respect to the actual legislative framework, the proper use of in silico evaluation could offer a ...
Anca Maria Juncan, Luca-Liviu Rus, Claudiu Morgovan, Felicia Loghin   +3 more
doaj   +1 more source