Results 61 to 70 of about 3,088,451 (275)

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Adapting High-Resolution Respirometry to Glucose-Limited Steady State Mycelium of the Filamentous Fungus Penicillium ochrochloron: Method Development and Standardisation.

PLoS ONE, 2016
Fungal electron transport systems (ETS) are branched, involving alternative NADH dehydrogenases and an alternative terminal oxidase. These alternative respiratory enzymes were reported to play a role in pathogenesis, production of antibiotics and ...
Christoph W Schinagl, Pamela Vrabl, Wolfgang Burgstaller   +2 more
doaj   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Change of AOX1a Expression, Encoding Mitochondrial Alternative Oxidase, Influence on the Frost-Resistance of Arabidopsis Plants [PDF]

Journal of Stress Physiology & Biochemistry, 2016
The resistance of Arabidopsis thaliana (L.) Heynh (Columbia ecotype) plants: Col-0 line (wild type), AS-12 line (plants transformed with the construct carrying the AOX1a gene under control of the CAMV 35S promoter in the antisense orientation) and line ...
Olga I. Grabelnych, Olga A. Borovik, Tamara P. Pobezhimova, Nina A. Koroleva, Irina V. Lyubushkina, Natalya S. Zabanova, Victor K. Voinikov   +6 more
doaj  

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

AOX Affects the Synthesis of Polysaccharides by Regulating the Reactive Oxygen Species in Ganoderma lucidum

Foods
Alternative oxidase (AOX) is a terminal oxidase in the mitochondrial electron transport chain that does not contribute to the generation of ATP. It plays a critical role in maintaining the balance between reactive oxygen species (ROS) production and ...
Ruiying Zhu, Lele Zhang, Longxi Wu, Jingshuo Liu, Jie Zhang, Jian Li, Kejing Song, Peipei Han   +7 more
doaj   +1 more source

Cloning of an Additional cDNA for the Alternative Oxidase in Tobacco [PDF]

Plant Physiology, 1995
The alternative oxidase is a cyanide-insensitive terminal oxidase found in a variety of organisms although it is best characterized in plants. It branches from the Cyt chain at the level of ubiquinone and does not pump protons and is thus non-energy-conserving. In thermogenic floral appendages it plays a clear role in the volatilization of compounds to
J, Whelan, M K, Smith, M, Meijer, J W, Yu, M R, Badger, G D, Price, D A, Day   +6 more
openaire   +2 more sources

Non‐Additive Criteria Assessment in Sustainability Evaluation of High Entropy Alloys: A Toxicity‐Weighted Framework

Advanced Engineering Materials, EarlyView.
Sustainability assessment requires methodologies that appropriately distinguish between additive and non‐additive material properties. A toxicity‐weighted scoring system is developed and applied that accounts for the disproportionate influence of highly toxic constituents through nonlinear weighting functions, providing more realistic estimates than ...
Seth Mehalic, Oladele A. Ogunseitan, Julie M. Schoenung   +2 more
wiley   +1 more source

Towards the directed evolution of an L-aspartate oxidase from Pseudomonas putida [PDF]

, 2012
Amino acid oxidases (AAOs) are enantioselective flavoenzymes that catalyse the oxidation of amino acids into imino acids, which spontaneously hydrolyse in water to form keto acids. AAOs have several potential applications, most notably as biocatalysts in
Leese, Charlotte
core   +5 more sources

The Novel J-Domain Protein Mrj1 Is Required for Mitochondrial Respiration and Virulence in Cryptococcus neoformans

mBio, 2020
The opportunistic fungal pathogen Cryptococcus neoformans must adapt to the mammalian environment to establish an infection. Proteins facilitating adaptation to novel environments, such as chaperones, may be required for virulence.
Linda C. Horianopoulos, Guanggan Hu, Mélissa Caza, Kerstin Schmitt, Peter Overby, James D. Johnson, Oliver Valerius, Gerhard H. Braus, James W. Kronstad   +8 more
doaj   +1 more source