Results 91 to 100 of about 7,204,743 (394)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

Frontiers in Immunology, 2019
Properdin enhances complement-mediated opsonization of targeted cells and particles for immune clearance. Properdin occurs as dimers, trimers and tetramers in human plasma, which recognize C3b-deposited surfaces, promote formation, and prolong the ...
Ramon M. van den Bos, Nicholas M. Pearce, Joke Granneman, T. Harma C. Brondijk, Piet Gros   +4 more
doaj   +1 more source

SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate

Clinical & Translational Immunology, 2022
Objectives To determine whether SARS‐CoV‐2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect.
Martin W Lo, Alberto A Amarilla, John D Lee, Eduardo A Albornoz, Naphak Modhiran, Richard J Clark, Vito Ferro, Mohit Chhabra, Alexander A Khromykh, Daniel Watterson, Trent M Woodruff   +10 more
doaj   +1 more source

Student access to higher education through alternative pathways and differences by equity group and discipline [PDF]

, 2023
Denise Jackson, Ian Li, David Carroll
openalex   +1 more source

Bio-inspired analog parallel array processor chip with programmable spatio-temporal dynamics [PDF]

, 2002
A bio-inspired model for an analog parallel array processor (APAP), based on studies on the vertebrate retina, permits the realization of complex spatio-temporal dynamics in VLSI.
Carmona Galán, Ricardo, Domínguez Castro, Rafael, Espejo Meana, Servando Carlos, Jiménez Garrido, Francisco José, Rodríguez Vázquez, Ángel Benito   +4 more
core   +1 more source

Alternate pathways of cerebroside catabolism [PDF]

Lipids, 1973
AbstractA search was made for new degradative pathways for glucosyl and galactosyl ceramides in an effort to explain the failure of these lipids to accumulate in the brains of children with Krabbe's or Gaucher's disease. Using various buffers and incubation conditions, we tested brain homogenates from 12 day old rats with the stearate‐labeled and ...
Lin, Yuh‐nan, Radin, Norman S.
openaire   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Quantification of the Dynamics of the Vascular Flows in the Cerebral Arterial and Venous Trees

Biomedicines
Objective: Cerebral vascularization is made of the symmetrical arterial system, with muscular walls, and the venous system, more variable and dominated by sinuses and jugular veins.
Heimiri Monnier, Kimi Owashi, Pan Liu, Serge Metanbou, Cyrille Capel, Olivier Balédent   +5 more
doaj   +1 more source

Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases

Frontiers in Immunology, 2018
Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G).
Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Marcin Okrój, Anna M. Blom, Sanne A. W. van Kraaij, Elena B. Volokhina, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel, Lambertus P. W. J. van den Heuvel   +9 more
doaj   +1 more source