Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
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Corrigendum: Complement activation via the lectin and alternative pathway in patients with severe COVID-19. [PDF]
Front Immunol, 2023 Niederreiter J +7 more
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Complement Activation in Semisolid Media: Insolubilization of Alternative Pathway Convertases in Agar Gels with C3 Nephritic Factor-Containing Sera [PDF]
, 1977 Mohammed A. Arnaout +3 more
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Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Novel Functional Assay to Characterize Mutations in Alternative Pathway of Complement. [PDF]
J Clin Immunol, 2023 Gerber GF +4 more
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NetAurHPD: Network Auralization Hyperlink Prediction Model to Identify Metabolic Pathways from Metabolomics Data [PDF]
arXivMetabolite biosynthesis is regulated via metabolic pathways, which can be activated and deactivated within organisms. Understanding and identifying an organism's metabolic pathway network is a crucial aspect for various research fields, including crop and life stock breeding, pharmacology, and medicine.
arxiv
Learning where to Attend with Deep Architectures for Image Tracking [PDF]
arXiv, 2011 We discuss an attentional model for simultaneous object tracking and recognition that is driven by gaze data. Motivated by theories of perception, the model consists of two interacting pathways: identity and control, intended to mirror the what and where pathways in neuroscience models.
arxiv
An alternative pathway for fibrinolysis. I. The cleavage of fibrinogen by leukocyte proteases at physiologic pH. [PDF]
, 1975 E F Plow, T S Edgington
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Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
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SAR443809: a selective inhibitor of the complement alternative pathway, targeting complement factor Bb. [PDF]
Blood Adv, 2023 Rajagopal V +12 more
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