Results 121 to 130 of about 7,204,743 (394)

Fluorescent Visualization of In Vitro Mitochondrial DNA Transcription [PDF]

, 2019
Mitochondria are important organelles within eukaryotic cells especially for their role in metabolism and ATP production by the oxidative phosphorylation (OXPHOS) pathway. In human cells there are approximately 80 protein subunits that make up the OXPHOS
Bruce, Kelsey
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A New Tool for Complement Research: In vitro Reconstituted Human Classical Complement Pathway

Frontiers in Immunology, 2018
The complement, as part of the innate immune system, represents the first line of defense against Gram-negative bacteria invading the bloodstream. The complement system is a zymogen cascade that ultimately assemble into the so-called membrane attack ...
Michele Mutti, Katharina Ramoni, Gábor Nagy, Eszter Nagy, Valéria Szijártó   +4 more
doaj   +1 more source

625 A national survey of paediatric urgent and emergency care services offering alternative pathways to the paediatric emergency department [PDF]

, 2022
Philippa Anna Stilwell, Agnieszka Wojciechowska, Gareth Stuttard, Raziya Mitchell, Simon Kenny, Richard Owen, Ian Maconochie   +6 more
openalex   +1 more source

Natural antisense transcripts with coding capacity in Arabidopsis may have a regulatory role that is not linked to double-stranded RNA degradation [PDF]

, 2005
BACKGROUND: Overlapping transcripts in antisense orientation have the potential to form double-stranded RNA (dsRNA), a substrate for a number of different RNA-modification pathways.
Jen, C.H., Meyer, P., Michalopoulos, I., Westhead, D.R.   +3 more
core   +2 more sources

Liver regeneration: Alternative epithelial pathways [PDF]

The International Journal of Biochemistry & Cell Biology, 2011
Loss of hepatic tissue triggers a regenerative response in the whole organ. Under typical normal conditions, all hepatic cells (epithelial: hepatocytes and biliary epithelial cells; non-epithelial: stellate cells, macrophages and endothelial cells) undergo one to three rounds of replication to establish the original number of cells and restore organ ...
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B

Frontiers in Immunology, 2017
Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP.
Antonio F. Mendes-Sousa, Antonio F. Mendes-Sousa, Vladimir Fazito do Vale, Vladimir Fazito do Vale, Naylene C. S. Silva, Anderson B. Guimaraes-Costa, Marcos H. Pereira, Marcos H. Pereira, Mauricio R. V. Sant’Anna, Mauricio R. V. Sant’Anna, Fabiano Oliveira, Shaden Kamhawi, José M. C. Ribeiro, John F. Andersen, Jesus G. Valenzuela, Ricardo N. Araujo, Ricardo N. Araujo   +16 more
doaj   +1 more source

SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]

, 2016
Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M., Brandt, E.A., Collin, N., Coutinho-Abreu, I.V., Fazito Vale, V., Ferreira Mendes-Sousa, A., Ferreira, V.P., Gontijo, N.F., Horácio Pereira, M., Kamhawi, S., Kotsyfakis, M., Lima, K.F., Meneses, C., Nascimento Araújo, R., Oliveira, F., Pangburn, M.K., Rasouli, M., Ribeiro, J.M., Valenzuela, J.G.   +18 more
core   +1 more source