Results 131 to 140 of about 1,587,758 (374)
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source
The eBDIMS path-sampling server: generation, classification and interactive visualization of protein ensembles and transition pathways in 2D-motion space [PDF]
arXiv, 2018 The recent rise of cryo-EM and X-ray high-throughput techniques is providing a wealth of new structures trapped in different conformations. Understanding how proteins transition between different conformers, and how they relate to each other in terms of function is not straightforward, and highly depends on the choice of the right set of degrees of ...
arxiv
Editorial: Role of complement activation in kidney diseases
Frontiers in Medicine, 2023 Takashi Oda, Toshihiro Sawai
doaj +1 more source
Revista Cubana de Hematología, Inmunología y Hemoterapia, 2006 Las deficiencias congénitas de los componentes individuales de las vías clásica y alternativa del sistema del complemento, dan lugar a un conjunto de enfermedades de frecuencia relativamente baja. Las personas con deficiencias en estas funciones muestran
Yanelkys Cos Padrón +3 more
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Frontiers in Immunology, 2019 Pentraxin-3 (PTX3) and C-reactive protein (CRP) have been shown to regulate complement activation in vitro, but their role has not been investigated in complement consumption in vivo. Thrombotic microangiopathies (TMA) are often accompanied by complement
Eszter Trojnar +14 more
doaj +1 more source
Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass [PDF]
, 2018 Aims/hypothesis: Pancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways.
Biden, Trevor J. +11 more
core +3 more sources
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
The Relationships Among an Activity of the Alternative Pathway Respiratory Flux, a Content of Carbohydrates and a Frost-Resistance of Winter Wheat [PDF]
Journal of Stress Physiology & Biochemistry, 2013 A content of carbohydrates and dehydrins in the leaves, activities of the alternative (AP) and the cytochrome (CP) pathways of respiration in mitochondria, isolated from leaves, during cold hardening continuous light (5 °C) and dark conditions with ...
O.A. Borovik +4 more
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