Results 271 to 280 of about 7,204,743 (394)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation. [PDF]

Front Immunol, 2022
Gerogianni A, Dimitrov JD, Zarantonello A, Poillerat V, Chonat S, Sandholm K, McAdam KE, Ekdahl KN, Mollnes TE, Mohlin C, Roumenina LT, Nilsson PH.   +11 more
europepmc   +1 more source

Arginine Decarboxylase and Agmatinase: An Alternative Pathway for De Novo Biosynthesis of Polyamines for Development of Mammalian Conceptuses1

Biology of Reproduction, 2014
Xiaoqiu Wang, Wei Ying, K. Dunlap, Gang Lin, M. Satterfield, R. Burghardt, Guoyao Wu, F. Bazer   +7 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Baicalin relieves complement alternative pathway activation-induced lung inflammation through inhibition of NF-κB pathway. [PDF]

BMC Complement Med Ther
Li J, Zhang QY, Lu QY, Liu QZ, Guo L, Li M, Sun QY.   +6 more
europepmc   +1 more source

JAK/STAT: Why choose a classical or an alternative pathway when you can have both? [PDF]

J Cell Mol Med, 2022
Puigdevall L, Michiels C, Stewardson C, Dumoutier L.   +3 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors. [PDF]

J Biol Chem
Goodrich AC, LeClair NP, Shillova N, Morton WD, Wittwer AJ, Loyet KM, Hannoush RN.   +6 more
europepmc   +1 more source

Data for "Divergent urban land trajectories under alternative population projections within the shared socioeconomic pathways"

Ryan A. McManamay, Chris Vernon, Travis Thurber, Jing Gao, Brian C. O’Neill   +4 more
openalex   +2 more sources

The Hydroxyquinol Degradation Pathway in Rhodococcus jostii RHA1 and Agrobacterium Species Is an Alternative Pathway for Degradation of Protocatechuic Acid and Lignin Fragments

, 2020
Edward Spence, Heather T. Scott, Louison Dumond, Leonides Calvo-Bado, Sabrina di Monaco, James J. Williamson, Gabriela Félix Persinoti, Fábio M. Squina, Timothy D. H. Bugg   +8 more
openalex   +2 more sources