Results 71 to 80 of about 1,609,187 (354)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Functional evaluation of rare variants in complement factor I using a minigene assay

Frontiers in Immunology
The regulatory serine protease, complement factor I (FI), in conjunction with one of its cofactors (FH, C4BP, MCP, or CR1), plays an essential role in controlling complement activity through inactivation of C3b and C4b.
Cobey J. H. Donelson, Nicolo Ghiringhelli Borsa, Amanda O. Taylor, Richard J. H. Smith, Yuzhou Zhang   +4 more
doaj   +1 more source

SARS‐CoV‐2 triggers complement activation through interactions with heparan sulfate

Clinical & Translational Immunology, 2022
Objectives To determine whether SARS‐CoV‐2 can trigger complement activation, the pathways that are involved and the functional significance of the resultant effect.
Martin W Lo, Alberto A Amarilla, John D Lee, Eduardo A Albornoz, Naphak Modhiran, Richard J Clark, Vito Ferro, Mohit Chhabra, Alexander A Khromykh, Daniel Watterson, Trent M Woodruff   +10 more
doaj   +1 more source

Alternative Wnt Pathways and Receptors [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a variety of other responses. These are often lumped together under the denominator "alternative" or "non-canonical" Wnt signaling, but they likely comprise distinct signaling events.
openaire   +3 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Factor H-related protein 1 in systemic lupus erythematosus

Frontiers in Immunology
BackgroundFactor H (FH) is a major soluble inhibitor of the complement system and part of a family comprising five related proteins (FHRs 1–5). Deficiency of FHR1 was described to be linked to an elevated risk of systemic lupus erythematosus (SLE).
Jessica S. Kleer, Jessica S. Kleer, Juliane Klehr, Denise Dubler, Laura Infanti, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg, Marten Trendelenburg   +9 more
doaj   +1 more source

Functional variant rs12614 in CFB confers a low risk of IgA nephropathy by attenuating complement alternative pathway activation in Han Chinese

Frontiers in Immunology, 2022
Activation of the alternative pathway (AP) of complement is thought to play an important role in Immunoglobin A nephropathy (IgAN). Our previous study showed that rs4151657 within the complement factor B (CFB) gene increased the risk of IgAN. The protein
Dian-Chun Shi, Dian-Chun Shi, Dian-Chun Shi, Shao-Zhen Feng, Shao-Zhen Feng, Zhong Zhong, Zhong Zhong, Lu Cai, Lu Cai, Meng Wang, Meng Wang, Dong-Ying Fu, Dong-Ying Fu, Xue-Qing Yu, Xue-Qing Yu, Xue-Qing Yu, Ming Li, Ming Li, Ming Li   +18 more
doaj   +1 more source

Bio-inspired analog parallel array processor chip with programmable spatio-temporal dynamics [PDF]

, 2002
A bio-inspired model for an analog parallel array processor (APAP), based on studies on the vertebrate retina, permits the realization of complex spatio-temporal dynamics in VLSI.
Carmona Galán, Ricardo, Domínguez Castro, Rafael, Espejo Meana, Servando Carlos, Jiménez Garrido, Francisco José, Rodríguez Vázquez, Ángel Benito   +4 more
core   +1 more source

Is There an Alternative Pathway for Starch Synthesis? [PDF]

Plant Physiology, 1992
In leaf tissue, carbon enters starch via the gluconeogenesis pathway where d-glycerate 3-phosphate formed from CO(2) fixation is converted into hexose monophosphates within the chloroplast stroma. In starch-containing sink organs, evidence has been obtained indicating that the flow of carbon into starch follows a different pathway whereby hexose ...
openaire   +3 more sources

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source