Results 1 to 10 of about 50,768 (179)
Coupling of alternative splicing and alternative polyadenylation. [PDF]
Acta Biochim Biophys Sin (Shanghai)RNA splicing and 3'-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative splicing (AS) and alternative polyadenylation (APA).
Zhang X, Liu F, Zhou Y.
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Extensive alternative polyadenylation during zebrafish development [PDF]
Genome Research, 2012 The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3′ untranslated regions (3′ UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-seq) to map poly(A) sites at eight developmental stages and tissues in the zebrafish.
Ulitsky, Igor +7 more
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APC mutations dysregulate alternative polyadenylation in cancer. [PDF]
Genome BiolAbstract Background Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood. Results We describe an unbiased analysis of molecular ...
Gabel AM +4 more
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Alternative Polyadenylation Blooms [PDF]
Developmental Cell, 2010 Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
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Alternative polyadenylation of cyclooxygenase-2 [PDF]
Nucleic Acids Research, 2005 A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased transcriptional activity accounts for only part of the upregulation of COX-2, we chose to explore other RNA ...
Hall-Pogar, Tyra +3 more
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Alternative polyadenylation of mRNA precursors [PDF]
Nature Reviews Molecular Cell Biology, 2016 Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation.
Bin, Tian, James L, Manley
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Alternative Polyadenylation: Another Foe in Cancer [PDF]
Molecular Cancer Research, 2016 Abstract Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer
Erson-Bensan, Ayse Elif, Can, Tolga
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Template-switching artifacts resemble alternative polyadenylation [PDF]
BMC Genomics, 2019 Abstract Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally disregarded, while alternative ...
Zsolt Balázs +5 more
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Alternative polyadenylation [PDF]
Plant Signaling & Behavior, 2009 Based on comparative genome analyses, the increases in protein-coding gene number could not account for the increases of morphological and behavioral complexity of higher eukaryotes. Transcriptional regulations, alternative splicing and the involvement of non-coding RNA in gene expression regulations have been credited for the drastic increase of ...
Denghui, Xing, Qingshun Quinn, Li
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Global insights into alternative polyadenylation regulation [PDF]
RNA Biology, 2015 Alternative pre-mRNA processing greatly increases the coding capacity of the human genome and regulatory factors involved in RNA processing play critical roles in tissue development and maintenance. Indeed, abnormal functions of RNA processing factors have been associated with a wide range of human diseases from cancer to neurodegenerative disorders ...
Ranjan, Batra +2 more
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