Coupling of alternative splicing and alternative polyadenylation [PDF]
Acta Biochimica et Biophysica SinicaRNA splicing and 3′-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative ...
Zhang Xueying, Liu Feiyan, Zhou Yu
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APC mutations dysregulate alternative polyadenylation in cancer [PDF]
Genome BiologyBackground Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood.
Austin M. Gabel +4 more
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Stage-Specific Alternative Polyadenylation During Human Neural Differentiation Revealed by Integrated Long- and Short-Read Sequencing [PDF]
BiologyHuman embryonic stem cell (hESC) neural differentiation involves extensive APA; however, reliance on short-read sequencing in prior studies has offered only a limited view of its complexity and dynamic regulation. Here, we integrated Oxford Nanopore (ONT)
Zheqi Lou +7 more
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Interplay between Alternative Splicing and Alternative Polyadenylation Defines the Expression Outcome of the Plant Unique OXIDATIVE TOLERANT-6 Gene [PDF]
Scientific Reports, 2017 Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li +3 more
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G-quadruplexes in the proximity 3′-UTR enhances alternative polyadenylation of Neogenin 1 [PDF]
iScienceSummary: Polyadenylation is a crucial step in mRNA maturation. Fifty percent of the time alternative polyadenylation sites (PASs) are used instead of canonical ones, affecting the length of the transcripts’ 3′-UTRs.
Pauline Lejault +3 more
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HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution [PDF]
mBioHIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures.
Charlotte Luchsinger +9 more
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mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases
Genes and Diseases, 2023 The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase, poly(A)
Siyao Guo, Shuibin Lin
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The landscape of alternative polyadenylation in single cells of the developing mouse embryo
Nature Communications, 2021 Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are ...
Vikram Agarwal +3 more
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Bioinformatics analysis and alternative polyadenylation in Heat Shock Proteins 70 (HSP70) family members. [PDF]
Int J Physiol Pathophysiol PharmacolShriya S +4 more
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Frontiers in Cell and Developmental Biology, 2021 Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism required for cleavage and polyadenylation (CPA) of the 3′ untranslated region (3′ UTR) of mRNAs.
Shi-lu Chen +15 more
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