AltTrans: Transcript pattern variants annotated for both alternative splicing and alternative polyadenylation [PDF]
BMC Bioinformatics, 2006 Background The three major mechanisms that regulate transcript formation involve the selection of alternative sites for transcription start (TS), splicing, and polyadenylation.
Lopez Fabrice +6 more
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Coupling of alternative splicing and alternative polyadenylation [PDF]
Acta Biochimica et Biophysica SinicaRNA splicing and 3′-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative ...
Zhang Xueying, Liu Feiyan, Zhou Yu
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Alternative Splicing and Polyadenylation Contribute to the Generation of hERG1 C-terminal Isoforms [PDF]
, 2010 The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel. Several hERG1 isoforms with different N- and C-terminal ends have been identified.
Gong, Qiuming +4 more
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Template-switching artifacts resemble alternative polyadenylation [PDF]
BMC Genomics, 2019 Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally ...
Zsolt Balázs +5 more
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APC mutations dysregulate alternative polyadenylation in cancer [PDF]
Genome BiologyBackground Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood.
Austin M. Gabel +4 more
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WDR33 alternative polyadenylation is dependent on stochastic poly(a) site usage and splicing efficiencies [PDF]
RNA BiologyTranscripts from the human WDR33 gene, which encodes a central component of the mRNA polyadenylation (PA) machinery, are subject to alternative polyadenylation (APA) within promoter-proximal introns/exons.
Lizhi Liu +2 more
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Deciphering Estrus Expression in Gilts: The Role of Alternative Polyadenylation and LincRNAs in Reproductive Transcriptomics [PDF]
AnimalsThe fertility rate and litter size of female pigs are critically affected by the expression of estrus. The objective of this study was to elucidate the regulatory mechanisms of estrus expression by analyzing the differential expression of genes and long ...
Mingzheng Liu +9 more
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The landscape of alternative polyadenylation in single cells of the developing mouse embryo
Nature Communications, 2021 Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are ...
Vikram Agarwal +3 more
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Frontiers in Cell and Developmental Biology, 2021 Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism required for cleavage and polyadenylation (CPA) of the 3′ untranslated region (3′ UTR) of mRNAs.
Shi-lu Chen +15 more
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Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR. [PDF]
PLoS ONE, 2015 About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that this coupling may be an intrinsic mechanism to directly regulate the host gene's expression ...
Ludwig Christian Hinske +7 more
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