Results 121 to 130 of about 51,497 (273)

Identification of candidate regulatory sequences in mammalian 3' UTRs by statistical analysis of oligonucleotide distributions [PDF]

, 2007
3' untranslated regions (3' UTRs) contain binding sites for many regulatory elements, and in particular for microRNAs (miRNAs). The importance of miRNA-mediated post-transcriptional regulation has become increasingly clear in the last few years.
Caselle, Michele, Cora, Davide, Di Cunto, Ferdinando, Provero, Paolo   +3 more
core   +4 more sources

RNA elements and their biotechnological applications in plants

New Phytologist, EarlyView.
Summary Engineering of plants for improved traits and efficient heterologous protein production can be achieved by modifying or introducing cis‐ or trans‐acting RNA elements. The function of these elements depends not only on their nucleotide sequence but also on their highly dynamic higher order structures.
Filip Lastovka, Hadrien Peyret, George P. Lomonossoff, Betty Y.‐W. Chung   +3 more
wiley   +1 more source

Salt Stress Adaptations in Soybean Involve Alterations in Pre‐mRNA Processing

Plant, Cell &Environment, EarlyView.
ABSTRACT Salt stress can seriously affect plant survival. To adapt to salt stress, plants can alter gene expressions and/or pre‐mRNA processing patterns, or both. Previous studies could not comprehensively profile stress‐responsive pre‐mRNA processing patterns due to limitations in traditional sequencing technologies.
Shoudong Zhang, Zhixia Xiao, Ailin Liu, Dongpeng Ren, Shengjie Chen, Hanxue Zhang, Li Zhang, Zhili Wang, Jun Yang, Hon‐Ming Lam   +9 more
wiley   +1 more source

Unveiling roles of non‐coding RNAs in cancer through advanced technologies

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Non‐coding RNAs (ncRNAs) have emerged as key regulators in tumorigenesis. In this perspective, we briefly review the significance of ncRNA in cancer biology and highlight recent technological advancements in characterization of ncRNA in cancer research. Specifically, we discuss how these advanced approaches, such as Patho‐DBiT, CRISPR screens,
Runhao Wang, Leng Han
wiley   +1 more source

Evaluation of Stem-Loop Reverse Transcription and Poly-A Tail Extension in MicroRNA Analysis of Body Fluids [PDF]

, 2014
MicroRNA has been demonstrated to be a viable tool for body fluid identification purposes in forensic casework. Stem-loop reverse transcription (slRT) is regularly used for cDNA synthesis from mature miRNA, along with poly-A tail extension.
Dunnett, Hannah, Van der Meer, Dieudonne, Williams, Graham   +2 more
core   +1 more source

Spliceosome protein alterations differentiate hubs of the default mode connectome during the progression of Alzheimer's disease

Brain Pathology, Volume 35, Issue 5, September 2025.
Default mode network (DMN) consists, in part, of the frontal (FC), precuneus (PreC), and posterior cingulate cortex (PCC), which plays a critical role in episodic memory and retrieval of autobiographical memories, displays spatiotemporal differences in the onset of amyloid and hypometabolism that reflects tau neurodegeneration and loss of connectivity ...
Sylvia E. Perez, Muhammad Nadeem, Bin He, Jennifer C. Miguel, David G. Moreno, Marta Moreno‐Rodriguez, Michael Malek‐Ahmadi, Chadwick M. Hales, Elliott J. Mufson   +8 more
wiley   +1 more source

Mechanisms driving functional divergence of transcription factor paralogs

New Phytologist, Volume 247, Issue 5, Page 2022-2033, September 2025.
Summary Transcription factors (TFs) are core components of the regulatory toolkits that control gene expression. The sophistication of these regulatory toolkits dramatically increased during Eukaryotic evolution, accomplished in part by the duplication of existing TFs and the subsequent repurposing of these new paralogs. This process, termed functional
Isabella J. Higgins, Sarah G. Choudury, Aman Y. Husbands   +2 more
wiley   +1 more source

The drive to generate multiple forms of oncogenic cyclin D1 transcripts in mantle cell lymphoma

Biomarker Research, 2017
Alternative polyadenylation is a rapidly emerging form of gene regulation, which in its simplest form, enables the generation of mRNA transcripts that code for the same protein but have 3′UTRs of different lengths and regulatory content.
Chioniso Patience Masamha
doaj   +1 more source

A Role for Pre-mRNA-PROCESSING PROTEIN 40C in the Control of Growth, Development, and Stress Tolerance in Arabidopsis thaliana [PDF]

, 2019
Because of their sessile nature, plants have adopted varied strategies for growing and reproducing in an ever-changing environment. Control of mRNA levels and pre-mRNA alternative splicing are key regulatory layers that contribute to adjust and ...
Careno, Daniel Alejandro, de Leone, María José, García Hourquet, Mariano, Hernando, Carlos Esteban, Iserte, Javier Alonso, Mora Garcia, Santiago, Yanovsky, Marcelo Javier   +6 more
core   +1 more source

Alternative Splicing Regulation in Metabolic Disorders

Obesity Reviews, Volume 26, Issue 9, September 2025.
ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley   +1 more source