Results 11 to 20 of about 28,556 (226)
Alternative Polyadenylation in Human Diseases [PDF]
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang +2 more
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Template-switching artifacts resemble alternative polyadenylation [PDF]
BMC Genomics, 2019 Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally ...
Zsolt Balázs +5 more
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Alternative Polyadenylation: Methods, Findings, and Impacts
Genomics, Proteomics & Bioinformatics, 2017 Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3â² ends originate from distinct polyadenylation sites of a single gene, is emerging as a mechanism widely used to regulate gene expression.
Wei Chen +5 more
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Transcriptional activity regulates alternative cleavage and polyadenylation
Molecular Systems Biology, 2011 Genes containing multiple pre‐mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs).
Zhe Ji +6 more
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Alternative Polyadenylation Blooms [PDF]
Developmental Cell, 2010 Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
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Alternative polyadenylation of cyclooxygenase-2 [PDF]
Nucleic Acids Research, 2005 A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased transcriptional activity accounts for only part of the upregulation of COX-2, we chose to explore other RNA ...
Hall-Pogar, Tyra +3 more
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Editorial: Alternative Polyadenylation in Development and Disease
Frontiers in Genetics, 2022 Athma A. Pai, Yang I. Li, Paolo Provero
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Alternative polyadenylation of mRNA precursors [PDF]
Nature Reviews Molecular Cell Biology, 2016 Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation.
Bin, Tian, James L, Manley
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Alternative Polyadenylation: Another Foe in Cancer [PDF]
Molecular Cancer Research, 2016 Abstract Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer
Erson-Bensan, Ayse Elif, Can, Tolga
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The Dynamic Landscape of 3'-UTR Alternative Polyadenylation Across Mouse Fetal Development and Anatomy. [PDF]
Adv Sci (Weinh)Wang Q, Chen X, Zhang XO.
europepmc +3 more sources