Results 11 to 20 of about 51,497 (273)
Alternative Polyadenylation in Human Diseases [PDF]
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang +2 more
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Alternative Polyadenylation: Methods, Findings, and Impacts
Genomics, Proteomics & Bioinformatics, 2017 Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3â² ends originate from distinct polyadenylation sites of a single gene, is emerging as a mechanism widely used to regulate gene expression.
Wei Chen +5 more
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Editorial: Alternative Polyadenylation in Development and Disease
Frontiers in Genetics, 2022 Athma A. Pai, Yang I. Li, Paolo Provero
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Transcriptional activity regulates alternative cleavage and polyadenylation
Molecular Systems Biology, 2011 Genes containing multiple pre‐mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs).
Zhe Ji +6 more
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E2F mediates enhanced alternative polyadenylation in proliferation [PDF]
Genome Biology, 2012 Abstract Background The majority of mammalian genes contain multiple poly(A) sites in their 3' UTRs. Alternative cleavage and polyadenylation are emerging as an important layer of gene regulation as they generate transcript isoforms that differ in their 3' UTRs, thereby modulating genes' response to 3 ...
Ran Elkon +6 more
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Driving glioblastoma growth by alternative polyadenylation [PDF]
Cell Research, 2014 Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.
Ting Han, John K. Kim
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Regulation of Alternative Polyadenylation by U1 snRNPs and SRp20 [PDF]
Molecular and Cellular Biology, 1998 Although considerable information is currently available about the factors involved in constitutive vertebrate polyadenylation, the factors and mechanisms involved in facilitating communication between polyadenylation and splicing are largely unknown.
Hua Jane Lou +3 more
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Alternative Polyadenylation Blooms [PDF]
Developmental Cell, 2010 Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
James L. Manley, Emanuel Rosonina
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Promoters drive alternative polyadenylation [PDF]
Nature Reviews Molecular Cell Biology, 2015 The RNA-binding protein Elav is recruited in the fruit fly to promoter regions, possibly by paused RNA polymerase II, to promote alternative polyadenylation.
Eytan Zlotorynski
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Alternative polyadenylation of cyclooxygenase-2 [PDF]
Nucleic Acids Research, 2005 A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased transcriptional activity accounts for only part of the upregulation of COX-2, we chose to explore other RNA ...
Carol S. Lutz +3 more
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