Results 21 to 30 of about 28,556 (226)
Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR. [PDF]
PLoS ONE, 2015 About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that this coupling may be an intrinsic mechanism to directly regulate the host gene's expression ...
Ludwig Christian Hinske +7 more
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Alternative polyadenylation [PDF]
Plant Signaling & Behavior, 2009 Based on comparative genome analyses, the increases in protein-coding gene number could not account for the increases of morphological and behavioral complexity of higher eukaryotes. Transcriptional regulations, alternative splicing and the involvement of non-coding RNA in gene expression regulations have been credited for the drastic increase of ...
Denghui, Xing, Qingshun Quinn, Li
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Global insights into alternative polyadenylation regulation [PDF]
RNA Biology, 2015 Alternative pre-mRNA processing greatly increases the coding capacity of the human genome and regulatory factors involved in RNA processing play critical roles in tissue development and maintenance. Indeed, abnormal functions of RNA processing factors have been associated with a wide range of human diseases from cancer to neurodegenerative disorders ...
Ranjan, Batra +2 more
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Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2014 The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld +6 more
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Molecules, 2021 The neuronal Hu/ELAV-like proteins HuB, HuC and HuD are a class of RNA-binding proteins that are crucial for proper development and maintenance of the nervous system. These proteins bind to AU-rich elements (AREs) in the untranslated regions (3′-UTRs) of
Rebecca M. Sena +5 more
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Extensive alternative polyadenylation during zebrafish development [PDF]
Genome Research, 2012 The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3′ untranslated regions (3′ UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-seq) to map poly(A) sites at eight developmental stages and tissues in the zebrafish.
Ulitsky, Igor +7 more
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Scientific Reports, 2021 Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRNA isoforms in 70% of human genes.
Hyeon-Mu Cho +7 more
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Biased alternative polyadenylation in human tissues [PDF]
Genome Biology, 2005 Abstract Background Alternative polyadenylation is one of the mechanisms in human cells that give rise to a variety of transcripts from a single gene. More than half of the human genes have multiple polyadenylation sites (poly(A) sites), leading to variable mRNA and protein products.
Zhang, Haibo, Lee, Ju Youn, Tian, Bin
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Mechanisms and Consequences of Alternative Polyadenylation [PDF]
Molecular Cell, 2011 Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode multiple mRNA transcripts. In some cases, this changes the mRNA coding potential; in other cases, the code remains unchanged but the 3' UTR length is ...
Di Giammartino, Dafne Campigli +2 more
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Alterations in polyadenylation and its implications for endocrine disease
Frontiers in Endocrinology, 2013 IntroductionPolyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation.
Anders eRehfeld +3 more
doaj +1 more source