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Mechanisms and Consequences of Alternative Polyadenylation [PDF]
Molecular Cell, 2011 Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode multiple mRNA transcripts. In some cases, this changes the mRNA coding potential; in other cases, the code remains unchanged but the 3' UTR length is ...
James L. Manley +2 more
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Alternative polyadenylation of mRNA precursors [PDF]
Nature Reviews Molecular Cell Biology, 2016 Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation.
Bin Tian, James L. Manley
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Alternative polyadenylation is a determinant of oncogenic Ras function [PDF]
Science Advances, 2020 ABSTRACTAlternative polyadenylation of pre-mRNA has been recently shown to play important roles in development and cancer. Activating mutations in the Ras oncogene are common drivers of many human cancers but the mechanisms by which they cooperate with alternative polyadenylation are not known. By exploiting the genetics ofC. elegans, we identifiedcfim-
Aishwarya Subramanian +13 more
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Alternative Polyadenylation: Another Foe in Cancer [PDF]
Molecular Cancer Research, 2016 Abstract Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer
Erson-Bensan, Ayse Elif, Can, Tolga
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Molecules, 2021 The neuronal Hu/ELAV-like proteins HuB, HuC and HuD are a class of RNA-binding proteins that are crucial for proper development and maintenance of the nervous system. These proteins bind to AU-rich elements (AREs) in the untranslated regions (3′-UTRs) of
Rebecca M. Sena +5 more
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Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs [PDF]
, 2013 The reference annotations made for a genome sequence provide the framework for all subsequent analyses of the genome. Correct annotation is particularly important when interpreting the results of RNA-seq experiments where short sequence reads are mapped ...
A Derti +52 more
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Scientific Reports, 2021 Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRNA isoforms in 70% of human genes.
Hyeon-Mu Cho +7 more
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Regulation of alternative splicing and polyadenylation in neurons
Life Science Alliance, 2023 Cell-type–specific gene expression is a fundamental feature of multicellular organisms and is achieved by combinations of regulatory strategies. Although cell-restricted transcription is perhaps the most widely studied mechanism, co-transcriptional and post-transcriptional processes are also central to the spatiotemporal control of gene functions.
Seungjae Lee, Joseph I Aubee, Eric C Lai
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Biased alternative polyadenylation in human tissues [PDF]
Genome Biology, 2005 Abstract Background Alternative polyadenylation is one of the mechanisms in human cells that give rise to a variety of transcripts from a single gene. More than half of the human genes have multiple polyadenylation sites (poly(A) sites), leading to variable mRNA and protein products.
Haibo Zhang, Ju Youn Lee, Bin Tian
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Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2014 The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld +6 more
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