CFIm25 in Solid Tumors: Current Research Progress
Technology in Cancer Research & Treatment, 2020 Cleavage factor I m25 is a newly discovered solid tumor-related gene, however, its precise role in cancer pathogenesis has not yet been characterized.
Xiaojie Sun MD, PhD +4 more
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BMC Bioinformatics, 2006 Background The three major mechanisms that regulate transcript formation involve the selection of alternative sites for transcription start (TS), splicing, and polyadenylation.
Lopez Fabrice +6 more
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Driving glioblastoma growth by alternative polyadenylation [PDF]
Cell Research, 2014 Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.
Ting, Han, John K, Kim
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Protocol for unlocking alternative polyadenylation insights from bulk RNA-seq data with PolyAMiner-Bulk. [PDF]
STAR ProtocJonnakuti V +2 more
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Alternative polyadenylation and RNA-binding proteins [PDF]
Journal of Molecular Endocrinology, 2016 Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and ...
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Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation [PDF]
Cell, 2010 The emerging discoveries on the link between polyadenylation and disease states underline the need to fully characterize genome-wide polyadenylation states. Here, we report comprehensive maps of global polyadenylation events in human and yeast generated using refinements to the Direct RNA Sequencing technology.
Ozsolak, Fatih +7 more
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Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
Genome Biology, 2021 Background Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends.
Ankeeta Shah +3 more
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Supervised analysis of alternative polyadenylation from single-cell and spatial transcriptomics data with spvAPA. [PDF]
Brief BioinformZhang Q, Kang L, Yang H, Liu F, Wu X.
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Regulation of alternative polyadenylation by genomic imprinting [PDF]
Genes & Development, 2008 Maternally and paternally derived alleles can utilize different promoters, but allele-specific differences in cotranscriptional processes have not been reported. We show that alternative polyadenylation sites at a novel murine imprinted gene ( H13 ) are utilized in an allele-specific manner ...
Wood, Andrew J. +7 more
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E2F mediates enhanced alternative polyadenylation in proliferation [PDF]
Genome Biology, 2012 Abstract Background The majority of mammalian genes contain multiple poly(A) sites in their 3' UTRs. Alternative cleavage and polyadenylation are emerging as an important layer of gene regulation as they generate transcript isoforms that differ in their 3' UTRs, thereby modulating genes' response to 3 ...
Elkon R +6 more
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