Results 41 to 50 of about 51,497 (273)

The contribution of alternative polyadenylation to the cancer phenotype [PDF]

Carcinogenesis, 2017
Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as alternative polyadenylation (APA ...
Chioniso P Masamha, Eric J Wagner
openaire   +3 more sources

Polyadenylation: alternative lifestyles of the A-rich (and famous?) [PDF]

The EMBO Journal, 2010
EMBO J 29 9, 1523–1536 (2010); published online March252010 [PMC free article] [PubMed] Alternative polyadenylation has a major function in gene expression and is often mediated through signals that lack canonical signatures. In this issue, Nunes et al (2010) uncover a new upstream A-rich sequence element that in conjunction with a strong U/GU-rich ...
Alexa M. Dickson, Jeffrey Wilusz
openaire   +3 more sources

Interplay between Alternative Splicing and Alternative Polyadenylation Defines the Expression Outcome of the Plant Unique OXIDATIVE TOLERANT-6 Gene

Scientific Reports, 2017
Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li, Zhaoyang Liu, Wenjia Lu, Man Liu   +3 more
doaj   +1 more source

RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]

, 2016
Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan, Ares, Manuel, Batra, Ranjan, Belzile, Jean-Philippe, Bos, Tomas J, Clark, Elizabeth, Donohue, John Paul, Gelboin-Burkhart, Chelsea, Huang, Hui, Huelga, Stephanie C, Rigo, Frank, Roberts, Brett T, Sathe, Shashank, Spector, Deborah H, Stark, Thomas J, Wheeler, Emily C, Yee, Brian A, Yeo, Gene W   +17 more
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Global insights into alternative polyadenylation regulation [PDF]

RNA Biology, 2015
Alternative pre-mRNA processing greatly increases the coding capacity of the human genome and regulatory factors involved in RNA processing play critical roles in tissue development and maintenance. Indeed, abnormal functions of RNA processing factors have been associated with a wide range of human diseases from cancer to neurodegenerative disorders ...
Ranjan Batra, Maurice S. Swanson, Mini Manchanda   +2 more
openaire   +3 more sources

CRISPRpas: programmable regulation of alternative polyadenylation by dCas9 [PDF]

Nucleic Acids Research, 2021
Abstract Most human protein-coding genes produce alternative polyadenylation (APA) isoforms that differ in 3′ UTR size or, when coupled with splicing, have variable coding sequences. APA is an important layer of gene expression program critical for defining cell identity.
Jihae Shin, Qingbao Ding, Qingbao Ding, Bin Tian, Bin Tian, Luyang Wang, Erdene Baljinnyam, Yange Cui, Aysegul Guvenek   +8 more
openaire   +2 more sources

Relationship between NUDT21 mediated alternative polyadenylation process and tumor

Frontiers in Oncology, 2023
Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3’ end of RNA polymerase II transcripts from over 60% of human genes.
Shan Xiao, Huan Gu, Li Deng, Xiongtao Yang, Dan Qiao, Xudong Zhang, Tian Zhang, Tao Yu, Tao Yu   +8 more
doaj   +1 more source

Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. The standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for PDAC management due to the rapid acquisition of drug resistance by patients.
Bielli, Pamela, Capurso, Gabriele, Delle Fave, Gianfranco, Farini, Donatella, Panzeri, Valentina, Passacantilli, Ilaria, Pilozzi, Emanuela, Sette, Claudio   +7 more
core   +2 more sources

Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]

, 2002
Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T., Dheur, Sonia, Hector, Ronald E., Minvielle‐Sebastia, Lionel, Non, Priscilla J., Nykamp, Keith R., Swanson, Maurice S., Urbinati, Carl R., Wilson, Scott M.   +8 more
core   +3 more sources

Analysis of wheat SAGE tags reveals evidence for widespread antisense transcription [PDF]

, 2008
BACKGROUND: Serial Analysis of Gene Expression (SAGE) is a powerful tool for genome-wide transcription studies. Unlike microarrays, it has the ability to detect novel forms of RNA such as alternatively spliced and antisense transcripts, without the need ...
Barker, Gary L A, Berry, Simon, Biggi, Gaia F, Coghill, Jane, Dunwell, Jim, Edwards, Keith J, Gibbings, George, Poole, Rebecca L, Werner, Kay   +8 more
core   +2 more sources