Results 41 to 50 of about 28,556 (226)
CRISPRpas: programmable regulation of alternative polyadenylation by dCas9 [PDF]
Nucleic Acids Research, 2021 Abstract Most human protein-coding genes produce alternative polyadenylation (APA) isoforms that differ in 3′ UTR size or, when coupled with splicing, have variable coding sequences. APA is an important layer of gene expression program critical for defining cell identity.
Jihae Shin +6 more
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TAPAS: tool for alternative polyadenylation site analysis [PDF]
Bioinformatics, 2018 AbstractMotivationThe length of the 3′ untranslated region (3′ UTR) of an mRNA is essential for many biological activities such as mRNA stability, sub-cellular localization, protein translation, protein binding and translation efficiency. Moreover, correlation between diseases and the shortening (or lengthening) of 3′ UTRs has been reported in the ...
Ashraful Arefeen +3 more
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RNA regulatory elements and polyadenylation in plants
Frontiers in Plant Science, 2012 Alternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant.
Arthur G. Hunt
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Insects, 2022 During the messenger RNA (mRNA) maturation process, RNA polyadenylation is a key step, and is coupled to the termination of transcription. Various cis-acting elements near the cleavage site and their binding factors would affect the process of ...
Liying Fang +4 more
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BMC Medical Genomics, 2019 Background Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a ...
Radhika Patel +4 more
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Frontiers in Genetics, 2022 Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that most transcripts in humans undergo alternative splicing and alternative polyadenylation.
Ryan Lusk +8 more
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Relationship between NUDT21 mediated alternative polyadenylation process and tumor
Frontiers in Oncology, 2023 Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3’ end of RNA polymerase II transcripts from over 60% of human genes.
Shan Xiao +8 more
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Alternative Cleavage and Polyadenylation during Colorectal Cancer Development [PDF]
Clinical Cancer Research, 2012 Abstract Purpose: Alternative cleavage and polyadenylation (APA) of mRNAs is a phenomenon that alters 3′-untranslated region length leading to altered posttranscriptional regulation of gene expression. Changing APA patterns have been shown to result in misregulation of genes involved in carcinogenesis; therefore, we hypothesized that ...
Morris AR +8 more
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Reprogramming of 3' untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types. [PDF]
PLoS ONE, 2009 The 3' untranslated regions (3'UTRs) of mRNAs contain cis elements involved in post-transcriptional regulation of gene expression. Over half of all mammalian genes contain multiple polyadenylation sites that lead to different 3'UTRs for a gene.
Zhe Ji, Bin Tian
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CFIm25 links alternative polyadenylation to glioblastoma tumour suppression [PDF]
Nature, 2014 The global shortening of messenger RNAs through alternative polyadenylation (APA) that occurs during enhanced cellular proliferation represents an important, yet poorly understood mechanism of regulated gene expression. The 3' untranslated region (UTR) truncation of growth-promoting mRNA transcripts that relieves intrinsic microRNA- and AU-rich-element-
Masamha, Chioniso P. +7 more
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