Results 51 to 60 of about 28,556 (226)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs

Frontiers in Genetics, 2019
The length of untranslated regions at the 3′ end of transcripts (3′UTRs) is regulated by alternate polyadenylation (APA). 3′UTRs contain regions that harbor binding motifs for regulatory molecules. However, the mechanisms that coordinate the 3′UTR length
Benjamin J. Harrison, Benjamin J. Harrison, Benjamin J. Harrison, Juw Won Park, Juw Won Park, Cynthia Gomes, Jeffrey C. Petruska, Jeffrey C. Petruska, Jeffrey C. Petruska, Matthew R. Sapio, Michael J. Iadarola, Julia H. Chariker, Julia H. Chariker, Eric C. Rouchka, Eric C. Rouchka   +14 more
doaj   +1 more source

Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers. [PDF]

Nat Commun
Zou X, Zhao Z, Chen Y, Xiong K, Wang Z, Chen S, Chen H, Wei GH, Xu S, Li W, Ni T, Li L.   +11 more
europepmc   +3 more sources

Conservation of alternative polyadenylation patterns in mammalian genes [PDF]

BMC Genomics, 2006
Abstract Background Alternative polyadenylation is a widespread mechanism contributing to transcript diversity in eukaryotes. Over half of mammalian genes are alternatively polyadenylated. Our understanding of poly(A) site evolution is limited by the lack of a reliable identification of conserved, equivalent poly(A ...
Ara, Takeshi, Lopez, Fabrice, Ritchie, William, Benech, Philippe, Gautheret, Daniel   +4 more
openaire   +3 more sources

Dynamic alternative polyadenylation during iPSC differentiation into cardiomyocytes

Computational and Structural Biotechnology Journal, 2022
Alternative polyadenylation (APA) is an important post-transcription regulatory mechanism widely occurring in eukaryotes and has been associated with special traits/diseases by several studies. However, the dynamic roles and patterns of APA in cell differentiation remain largely unknown. Here, we systematically characterized the APA profiles during the
Yanbo Yang, Xiaohong Wu, Wenqian Yang, Weiwei Jin, Dongyang Wang, Jianye Yang, Guanghui Jiang, Wen Zhang, Xiaohui Niu, Jing Gong   +9 more
openaire   +3 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study

Nature Communications
Alternative polyadenylation plays an important role in cancer initiation and progression; however, current transcriptome-wide association studies mostly ignore alternative polyadenylation when identifying putative cancer susceptibility genes.
Hui Chen, Zeyang Wang, Lihai Gong, Qixuan Wang, Wenyan Chen, Jia Wang, Xuelian Ma, Ruofan Ding, Xing Li, Xudong Zou, Mireya Plass, Cheng Lian, Ting Ni, Gong-Hong Wei, Wei Li, Lin Deng, Lei Li   +16 more
doaj   +1 more source

Regulation of alternative splicing and polyadenylation in neurons

Life Science Alliance, 2023
Cell-type–specific gene expression is a fundamental feature of multicellular organisms and is achieved by combinations of regulatory strategies. Although cell-restricted transcription is perhaps the most widely studied mechanism, co-transcriptional and post-transcriptional processes are also central to the spatiotemporal control of gene functions.
Seungjae Lee, Joseph I Aubee, Eric C Lai
openaire   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source