Results 61 to 70 of about 51,497 (273)

Alternative cleavage and polyadenylation in health and disease

Nature Reviews Genetics, 2019
Most human genes have multiple sites at which RNA 3' end cleavage and polyadenylation can occur, enabling the expression of distinct transcript isoforms under different conditions. Novel methods to sequence RNA 3' ends have generated comprehensive catalogues of polyadenylation (poly(A)) sites; their analysis using innovative computational methods has ...
Andreas J. Gruber, Mihaela Zavolan
openaire   +5 more sources

Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

BMC Medical Genomics, 2019
Background Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a ...
Radhika Patel, Cillian Brophy, Mark Hickling, Jonathan Neve, André Furger   +4 more
doaj   +1 more source

Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus [PDF]

, 2017
Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs).
Berciano, Maria T., Calderó i Pardo, Jordi, Lafarga, Miguel, Narcís, Oriol J., Piedrafita Llorens, Lídia, Riancho, Javier, Tapia, Olga, Tarabal Mostazo, Olga   +7 more
core   +2 more sources

Cell Cycle Regulation by Alternative Polyadenylation of CCND1 [PDF]

Scientific Reports, 2018
AbstractGlobal shortening of 3′UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the role of APA in cancer remains unknown.CCND1is a proto-oncogene that regulates progression through the G1-S phase of the cell cycle; moreover, it has been observed to be switching to proximal APA sites in cancer cells.
Mengmeng Hou, Qiong Wang, Anlong Xu, Anlong Xu, Liutao Chen, Guopei He, Yonggui Fu, Shangwu Chen   +7 more
openaire   +3 more sources

Epigenetic control of alternative mRNA processing at the imprinted Herc3/Nap1l5 locus [PDF]

, 2012
Alternative polyadenylation increases transcriptome diversity by generating multiple transcript isoforms from a single gene. It is thought that this process can be subject to epigenetic regulation, but few specific examples of this have been reported. We
Andrew J. Wood, Arnaud, Attia, Attia, Bourc'his, Chotalia, Cowley, Cowley, Cruz, Davies, de la Mata, Di Giammartino, Druker, Garcia-Gonzalo, Garfield, Gregg, Hsu, Kanber, Keane, Khaladkar, Letunic, Li, Lou, Luco, MacIsaac, Maunakea, Michael Cowley, Monk, Nakabayashi, Pan, Rebecca J. Oakey, Reik, Reiner Schulz, Sabrina Böhm, Schultz, Schulz, Shearwin, Smallwood, Smith, Spies, Takagaki, Wood, Wood, Wu, Yalcin, Zhang   +45 more
core   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study

Nature Communications
Alternative polyadenylation plays an important role in cancer initiation and progression; however, current transcriptome-wide association studies mostly ignore alternative polyadenylation when identifying putative cancer susceptibility genes.
Hui Chen, Zeyang Wang, Lihai Gong, Qixuan Wang, Wenyan Chen, Jia Wang, Xuelian Ma, Ruofan Ding, Xing Li, Xudong Zou, Mireya Plass, Cheng Lian, Ting Ni, Gong-Hong Wei, Wei Li, Lin Deng, Lei Li   +16 more
doaj   +1 more source

Alternative polyadenylation produces multiple 3’ untranslated regions of odorant receptor mRNAs in mouse olfactory sensory neurons

BMC Genomics, 2019
Background Odorant receptor genes constitute the largest gene family in mammalian genomes and this family has been extensively studied in several species, but to date far less attention has been paid to the characterization of their mRNA 3′ untranslated ...
Mohamed Doulazmi, Cyril Cros, Isabelle Dusart, Alain Trembleau, Caroline Dubacq   +4 more
doaj   +1 more source

Comparative transcriptome analysis of male and female flowers in Spinacia oleracea L

BMC Genomics, 2020
Background Dioecious spinach (Spinacia oleracea L.), a commercial and nutritional vegetable crop, serves as a model for studying the mechanisms of sex determination and differentiation in plants. However, this mechanism is still unclear. Herein, based on
Ning Li, Ziwei Meng, Minjie Tao, Yueyuan Wang, Yulan Zhang, Shufen Li, Wujun Gao, Chuanliang Deng   +7 more
doaj   +1 more source

MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease [PDF]

, 2015
MicroRNA (miRNA) has the potential for cross-regulation and functional integration of discrete biological processes during complex physiological events.
Akbar, Moeed, Campbell, Abigail L., Gilchrist, Derek, Kerr, Shauna C., Kurowska-Stolarska, Mariola, Liew, Foo Y., McInnes, Iain B., Millar, Neal L., Murrell, George A.C., Reilly, James H.   +9 more
core   +1 more source