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Alternative splicing across the tree of life [PDF]
eLifeThere is a growing understanding of how alternative splicing contributes to functional specialization and adaptation, especially in well-studied model organisms. However, its large-scale evolutionary dynamics remain poorly understood.
Rebeca de la Fuente +3 more
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Alternative Splicing in Angiogenesis
International Journal of Molecular Sciences, 2019 Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an
E. Bowler, S. Oltean
semanticscholar +4 more sources
Alternative Splicing and Cancer
Journal of Nucleic Acids, 2012 Alternative splicing of premessenger RNAs is a key step in the gene expression process, which allows the synthesis of different products from the same gene and contributes to increase the complexity of the proteome coded by a limited number of genes. Specialized high-throughput technologies (RNA-Seq, splicing-sensitive microarrays) aiming at analyzing ...
Didier Auboeuf +3 more
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Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer
Journal of Experimental & Clinical Cancer Research, 2020 Hypoxia-induced alternative splicing is a potent driving force in tumour pathogenesis and progression. In this review, we update currents concepts of hypoxia-induced alternative splicing and how it influences tumour biology.
Antonietta Rosella Farina +5 more
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Alternative Splicing in Neurogenesis and Brain Development
Frontiers in Molecular Biosciences, 2018 Alternative splicing of precursor mRNA is an important mechanism that increases transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA levels.
Chun-Hao Su +4 more
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Coupling of alternative splicing and alternative polyadenylation. [PDF]
Acta Biochim Biophys Sin (Shanghai)RNA splicing and 3'-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative splicing (AS) and alternative polyadenylation (APA).
Zhang X, Liu F, Zhou Y.
europepmc +5 more sources
Splicing and alternative splicing in rice and humans [PDF]
BMB Reports, 2013 Rice is a monocot gramineous crop, and one of the mostimportant staple foods. Rice is considered a model species formost gramineous crops. Extensive research on rice hasprovided critical guidance for other crops, such as maize andwheat.
Zhiguo E, Lei Wang, Jianhua Zhou
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Alternative splicing in stem cells and development: research progress and emerging technologies [PDF]
Cell RegenerationAlternative splicing is a key regulatory mechanism that generates transcriptomic diversity by selectively splicing pre-RNA molecules in different ways, leading to the production of multiple RNA isoforms from a single gene. This process is crucial for the
Yan Jin, XiaoLin Liang, Xiangting Wang
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Alternative splicing isoform of ADAR1-like computational and functional analysis in Ephinephelus malabaricus [PDF]
Comparative Immunology ReportsPeriyasamy T, Lu M, Chiou P.
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Temporal Dynamic Analysis of Alternative Splicing During Embryonic Development in Zebrafish
Frontiers in Cell and Developmental Biology, 2022 Alternative splicing is pervasive in mammalian genomes and involved in embryo development, whereas research on crosstalk of alternative splicing and embryo development was largely restricted to mouse and human and the alternative splicing regulation ...
Zhe Liu +11 more
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