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Alternative splicing across the tree of life [PDF]

eLife
There is a growing understanding of how alternative splicing contributes to functional specialization and adaptation, especially in well-studied model organisms. However, its large-scale evolutionary dynamics remain poorly understood.
Rebeca de la Fuente, Wladimiro Dı́az-Villanueva, Vicente Arnau, Andres Moya   +3 more
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Alternative Splicing and Cancer

Journal of Nucleic Acids, 2012
Alternative splicing of premessenger RNAs is a key step in the gene expression process, which allows the synthesis of different products from the same gene and contributes to increase the complexity of the proteome coded by a limited number of genes. Specialized high-throughput technologies (RNA-Seq, splicing-sensitive microarrays) aiming at analyzing ...
Didier Auboeuf, Maria Carmo-Fonseca, Juan Valcarcel, Giuseppe Biamonti   +3 more
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Temporal Dynamic Analysis of Alternative Splicing During Embryonic Development in Zebrafish

Frontiers in Cell and Developmental Biology, 2022
Alternative splicing is pervasive in mammalian genomes and involved in embryo development, whereas research on crosstalk of alternative splicing and embryo development was largely restricted to mouse and human and the alternative splicing regulation ...
Zhe Liu, Wei Wang, Xinru Li, Xinru Li, Xiujuan Zhao, Hongyu Zhao, Wuritu Yang, Wuritu Yang, Yongchun Zuo, Yongchun Zuo, Lu Cai, Yongqiang Xing   +11 more
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Alternative splicing during fruit development among fleshy fruits

BMC Genomics, 2021
Background Alternative splicing (AS) is an important mechanism of posttranscriptional modification and dynamically regulates multiple physiological processes in plants, including fruit ripening.
Xiaomin Yan, Dan Bai, Hongtao Song, Kui Lin, Erli Pang   +4 more
doaj   +1 more source

Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing

Computational and Structural Biotechnology Journal, 2021
Alternative splicing contributes to the majority of protein diversity in higher eukaryotes by allowing one gene to generate multiple distinct protein isoforms. It adds another regulation layer of gene expression.
Wei Jiang, Liang Chen
doaj   +1 more source

Global Survey of Alternative Splicing in Rice by Direct RNA Sequencing During Reproductive Development: Landscape and Genetic Regulation

Rice, 2021
Alternative splicing is a widespread phenomenon, which generates multiple isoforms of the gene product. Reproductive development is the key process for crop production. Although numerous forms of alternative splicing have been identified in model plants,
Haoxuan Li, Aixuan Li, Wei Shen, Nenghui Ye, Guanqun Wang, Jianhua Zhang   +5 more
doaj   +1 more source

Alternative Splice in Alternative Lice [PDF]

Molecular Biology and Evolution, 2015
Genomic and transcriptomics analyses have revealed human head and body lice to be almost genetically identical; although con-specific, they nevertheless occupy distinct ecological niches and have differing feeding patterns. Most importantly, while head lice are not known to be vector competent, body lice can transmit three serious bacterial diseases ...
Tovar-Corona, Jaime M., Castillo-Morales, Atahualpa, Chen, Lu, Olds, Brett P., Clark, John M., Reynolds, Stuart E., Pittendrigh, Barry R., Feil, Edward J., Urrutia, Araxi O.   +8 more
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Chromatin and Alternative Splicing [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2010
Alternative splicing affects more than 90% of human genes. Coupling between transcription and splicing has become crucial in the complex network underlying alternative splicing regulation. Because chromatin is the real template for nuclear transcription, changes in its structure, but also in the "reading" and "writing" of the histone code, could ...
Alló, M., Schor, I.E., Muñoz, M.J., De La Mata, M., Agirre, E., Valcárcel, J., Eyras, E., Kornblihtt, A.R.   +7 more
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Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. [PDF]

PLoS Genetics, 2008
Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect
Sergio Barberan-Soler, Alan M Zahler
doaj   +1 more source

Complex Alternative Splicing [PDF]

, 2007
Alternative splicing is a powerful means of controlling gene expression and increasing protein diversity. Most genes express a limited number of mRNA isoforms, but there are several examples of genes that use alternative splicing to generate hundreds, thousands and even tens of thousands of isoforms.
Jung Woo, Park, Brenton R, Graveley
openaire   +2 more sources