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Alternative Splicing in Neurogenesis and Brain Development
Frontiers in Molecular Biosciences, 2018 Alternative splicing of precursor mRNA is an important mechanism that increases transcriptomic and proteomic diversity and also post-transcriptionally regulates mRNA levels.
Chun-Hao Su +4 more
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The implications of alternative pre-mRNA splicing in cell signal transduction
Experimental and Molecular Medicine, 2023 Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing, key components of signal transduction pathways are no exception.
Sunkyung Choi, Namjoon Cho, Kee K. Kim
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The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins
Frontiers in Molecular Neuroscience, 2021 Neurexins are presynaptic cell-adhesion molecules essential for synaptic function that are expressed in thousands of alternatively spliced isoforms. Recent studies suggested that alternative splicing at splice site 4 (SS4) of Nrxn1 is tightly regulated ...
Kif Liakath-Ali +3 more
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Alternative Splicing: Emerging Roles in Anti-Aging Strategies
BiomoleculesAlternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence.
Lingyue Gao, Rong Jia
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Alternative Splicing in Apicomplexan Parasites
mBio, 2019 Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are ...
Lee M. Yeoh +3 more
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The role of alternative pre-mRNA splicing in cancer progression
Cancer Cell International, 2023 Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of specific splicing isoforms in cellular processes,
Sunkyung Choi +3 more
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Interrogation of alternative splicing events in duplicated genes during evolution
BMC Genomics, 2011 Background Gene duplication provides resources for developing novel genes and new functions while retaining the original functions. In addition, alternative splicing could increase the complexity of expression at the transcriptome and proteome level ...
Chen Ting-Wen +3 more
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BMC Evolutionary Biology, 2007 Background Alternative splicing has been reported in various eukaryotic groups including plants, apicomplexans, diatoms, amoebae, animals and fungi. However, whether widespread alternative splicing has evolved independently in the different eukaryotic ...
Penny David +3 more
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A Novel Prognostic Index Based on Alternative Splicing in Papillary Renal Cell Carcinoma
Frontiers in Genetics, 2020 BackgroundPapillary renal cell carcinoma (pRCC) is a heterogeneous multifocal or isolated tumor with an invasive phenotype. Previous studies presented that alternative splicing, as a crucial posttranscriptional regulator in gene expression, is associated
Zhipeng Wu +6 more
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Alternative splicing regulation and its therapeutic potential in bladder cancer
Frontiers in OncologyBladder cancer is one of the leading causes of mortality globally. The development of bladder cancer is closely associated with alternative splicing, which regulates human gene expression and enhances the diversity of functional proteins.
Lina Li, Ting Jin, Liang Hu, Jin Ding
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