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Alternative splicing across the C. elegans nervous system [PDF]

Nature Communications
Alternative splicing is a key mechanism that shapes transcriptomes, helping to define neuronal identity and modulate function. Here, we present an atlas of alternative splicing across the nervous system of Caenorhabditis elegans.
Alexis Weinreb, Erdem Varol, Alec Barrett, Rebecca M. McWhirter, Seth R. Taylor, Isabel Courtney, Manasa Basavaraju, Abigail Poff, John A. Tipps, Becca Collings, The CeNGEN Consortium, Smita Krishnaswamy, David M. Miller, Marc Hammarlund   +13 more
doaj   +2 more sources

Alternative Splicing: Emerging Roles in Anti-Aging Strategies [PDF]

Biomolecules
Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence.
Lingyue Gao, Rong Jia
doaj   +2 more sources

Alternative Splicing and Genomic Stability [PDF]

Physical Biology, volume 1, issue 2, pages C1 - C4, 2004, 2004
Alternative splicing allows an organism to make different proteins in different cells at different times, all from the same gene. In a cell that uses alternative splicing, the total length of all the exons is much shorter than in a cell that encodes the same set of proteins without alternative splicing.
arxiv   +6 more sources

Alternative Splicing and Cancer

Journal of Nucleic Acids, 2012
Alternative splicing of premessenger RNAs is a key step in the gene expression process, which allows the synthesis of different products from the same gene and contributes to increase the complexity of the proteome coded by a limited number of genes. Specialized high-throughput technologies (RNA-Seq, splicing-sensitive microarrays) aiming at analyzing ...
Didier Auboeuf, Maria Carmo-Fonseca, Juan Valcarcel, Giuseppe Biamonti   +3 more
doaj   +4 more sources

Alternative Splicing in Apicomplexan Parasites [PDF]

mBio, 2019
Alternative splicing is a widespread, essential, and complex component of gene regulation. Apicomplexan parasites have long been recognized to produce alternatively spliced transcripts for some genes and can produce multiple protein products that are ...
Lee M. Yeoh, V. Vern Lee, Geoffrey I. McFadden, Stuart A. Ralph   +3 more
doaj   +4 more sources

Alternative splicing in stem cells and development: research progress and emerging technologies [PDF]

Cell Regeneration
Alternative splicing is a key regulatory mechanism that generates transcriptomic diversity by selectively splicing pre-RNA molecules in different ways, leading to the production of multiple RNA isoforms from a single gene. This process is crucial for the
Yan Jin, XiaoLin Liang, Xiangting Wang
doaj   +2 more sources

Splicing and alternative splicing in rice and humans [PDF]

BMB Reports, 2013
Rice is a monocot gramineous crop, and one of the mostimportant staple foods. Rice is considered a model species formost gramineous crops. Extensive research on rice hasprovided critical guidance for other crops, such as maize andwheat.
Zhiguo E, Lei Wang, Jianhua Zhou
doaj   +5 more sources

Temporal Dynamic Analysis of Alternative Splicing During Embryonic Development in Zebrafish

Frontiers in Cell and Developmental Biology, 2022
Alternative splicing is pervasive in mammalian genomes and involved in embryo development, whereas research on crosstalk of alternative splicing and embryo development was largely restricted to mouse and human and the alternative splicing regulation ...
Zhe Liu, Wei Wang, Xinru Li, Xinru Li, Xiujuan Zhao, Hongyu Zhao, Wuritu Yang, Wuritu Yang, Yongchun Zuo, Yongchun Zuo, Lu Cai, Yongqiang Xing   +11 more
doaj   +1 more source

Alternative splicing during fruit development among fleshy fruits

BMC Genomics, 2021
Background Alternative splicing (AS) is an important mechanism of posttranscriptional modification and dynamically regulates multiple physiological processes in plants, including fruit ripening.
Xiaomin Yan, Dan Bai, Hongtao Song, Kui Lin, Erli Pang   +4 more
doaj   +1 more source

Alternative Splice in Alternative Lice [PDF]

Molecular Biology and Evolution, 2015
Genomic and transcriptomics analyses have revealed human head and body lice to be almost genetically identical; although con-specific, they nevertheless occupy distinct ecological niches and have differing feeding patterns. Most importantly, while head lice are not known to be vector competent, body lice can transmit three serious bacterial diseases ...
John M. Clark, Atahualpa Castillo-Morales, Araxi O. Urrutia, Stuart E. Reynolds, Jaime M. Tovar-Corona, Brett P. Olds, Barry R. Pittendrigh, Edward J. Feil, Lu Chen   +8 more
openaire   +3 more sources