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Coupling of alternative splicing and alternative polyadenylation [PDF]

Acta Biochimica et Biophysica Sinica
RNA splicing and 3′-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative ...
Zhang Xueying, Liu Feiyan, Zhou Yu
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Alternative splicing across the C. elegans nervous system [PDF]

Nature Communications
Alternative splicing is a key mechanism that shapes transcriptomes, helping to define neuronal identity and modulate function. Here, we present an atlas of alternative splicing across the nervous system of Caenorhabditis elegans.
Alexis Weinreb, Erdem Varol, Alec Barrett, Rebecca M. McWhirter, Seth R. Taylor, Isabel Courtney, Manasa Basavaraju, Abigail Poff, John A. Tipps, Becca Collings, The CeNGEN Consortium, Smita Krishnaswamy, David M. Miller, Marc Hammarlund   +13 more
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Alternative Splicing: Emerging Roles in Anti-Aging Strategies [PDF]

Biomolecules
Alternative splicing plays a fundamental role in gene expression and protein complexity. Aberrant splicing impairs cell homeostasis and is closely associated with aging and cellular senescence.
Lingyue Gao, Rong Jia
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Alternative splicing in stem cells and development: research progress and emerging technologies [PDF]

Cell Regeneration
Alternative splicing is a key regulatory mechanism that generates transcriptomic diversity by selectively splicing pre-RNA molecules in different ways, leading to the production of multiple RNA isoforms from a single gene. This process is crucial for the
Yan Jin, XiaoLin Liang, Xiangting Wang
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Temporal Dynamic Analysis of Alternative Splicing During Embryonic Development in Zebrafish

Frontiers in Cell and Developmental Biology, 2022
Alternative splicing is pervasive in mammalian genomes and involved in embryo development, whereas research on crosstalk of alternative splicing and embryo development was largely restricted to mouse and human and the alternative splicing regulation ...
Zhe Liu, Wei Wang, Xinru Li, Xinru Li, Xiujuan Zhao, Hongyu Zhao, Wuritu Yang, Wuritu Yang, Yongchun Zuo, Yongchun Zuo, Lu Cai, Yongqiang Xing   +11 more
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Alternative splicing during fruit development among fleshy fruits

BMC Genomics, 2021
Background Alternative splicing (AS) is an important mechanism of posttranscriptional modification and dynamically regulates multiple physiological processes in plants, including fruit ripening.
Xiaomin Yan, Dan Bai, Hongtao Song, Kui Lin, Erli Pang   +4 more
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Global Survey of Alternative Splicing in Rice by Direct RNA Sequencing During Reproductive Development: Landscape and Genetic Regulation

Rice, 2021
Alternative splicing is a widespread phenomenon, which generates multiple isoforms of the gene product. Reproductive development is the key process for crop production. Although numerous forms of alternative splicing have been identified in model plants,
Haoxuan Li, Aixuan Li, Wei Shen, Nenghui Ye, Guanqun Wang, Jianhua Zhang   +5 more
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Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. [PDF]

PLoS Genetics, 2008
Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect
Sergio Barberan-Soler, Alan M Zahler
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Alternative splicing in breast cancer

Journal of Bio-X Research, 2023
Alternative splicing allows a gene to produce multiple proteins and is the main source of human proteome diversity. Aberrant regulation of alternative splicing produces proteins with different structures and can lead to altered protein function ...
Xin Wen, Ze Yan, Li Sha
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Transcriptome Bioinformatical Analysis of Vertebrate Stages of Schistosoma japonicum Reveals Alternative Splicing Events. [PDF]

PLoS ONE, 2015
Alternative splicing is a molecular process that contributes greatly to the diversification of proteome and to gene functions. Understanding the mechanisms of stage-specific alternative splicing can provide a better understanding of the development of ...
Xinye Wang, Xindong Xu, Xingyu Lu, Yuanbin Zhang, Weiqing Pan   +4 more
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