Results 161 to 170 of about 2,471 (170)
Rewriting the Fate of Cancer: Epigenetic and Epitranscriptomic Regulators in the Metastatic Cascade. [PDF]
BiomoleculesHara T, Subramanian M.
europepmc +1 more source
5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader [PDF]
Cell Research, 2017 5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown. Here, we reveal that m5C modification is enriched in CG-rich regions and in regions immediately downstream of translation initiation sites
Ying Yang, Baofa Sun, Yu-Sheng Chen
exaly +3 more sources
ALYREF/THOC4 expression and cell growth modulation in retinoblastoma
Pathology Research and PracticeIn this study, we tested the hypothesis that ALYREF/THOC4, a poor prognostic factor in different cancer types, has potential as a drug target and prognostic biomarker for retinoblastoma (RB). Immunostaining (IHC), Western blot, and RT-qPCR analyses detected overexpression of ALYREF in the RB cell lines Y79, RB143, WERI-RB1, and RB116.
Onyekwere Onwumere
exaly +4 more sources
ALYREF mainly binds to the 5′ and the 3′ regions of the mRNA in vivo [PDF]
Nucleic Acids Research, 2017 The TREX complex (TREX) plays key roles in nuclear export of mRNAs. However, little is known about its transcriptome-wide binding targets. We used individual cross-linking and immunoprecipitation (iCLIP) to identify the binding sites of ALYREF, an mRNA export adaptor in TREX, in human cells.
Min Shi, Xudong Wu, Zhisong He
exaly +4 more sources
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Journal of Biomolecular Structure and Dynamics, 2023
Neuroblastoma is a tumour of the sympathetic nervous system mainly prevalent in children. Many strategies have been employed to target several drug-targetable proteins for the clinical management of neuroblastoma. However, the heterogeneous nature of neuroblastoma presents serious challenges in drug development for its treatment.
Nidhi Goswami +4 more
openaire +2 more sources
Neuroblastoma is a tumour of the sympathetic nervous system mainly prevalent in children. Many strategies have been employed to target several drug-targetable proteins for the clinical management of neuroblastoma. However, the heterogeneous nature of neuroblastoma presents serious challenges in drug development for its treatment.
Nidhi Goswami +4 more
openaire +2 more sources
Life Sciences
5-Methylcytosine (m5C) methylation is present in almost all types of RNA as an essential epigenetic modification. It is dynamically modulated by its associated enzymes, including m5C methyltransferases (NSUN, DNMT and TRDMT family members), demethylases (TET family and ALKBH1) and binding proteins (YTHDF2, ALYREF and YBX1).
Yan, Zhao, Cheng, Xing, Hongling, Peng
exaly +3 more sources
5-Methylcytosine (m5C) methylation is present in almost all types of RNA as an essential epigenetic modification. It is dynamically modulated by its associated enzymes, including m5C methyltransferases (NSUN, DNMT and TRDMT family members), demethylases (TET family and ALKBH1) and binding proteins (YTHDF2, ALYREF and YBX1).
Yan, Zhao, Cheng, Xing, Hongling, Peng
exaly +3 more sources
ALYREF regulates glucose metabolism and tumorigenesis in colorectal cancer [Poster]
2023Klec, Christiane +5 more
openaire +1 more source
Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration
GeroScience, 2022Rebecca L Kow +2 more
exaly