Results 71 to 80 of about 9,355,841 (357)

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Associations of renin–angiotensin system inhibitor use with brain insulin signaling and neuropathology

Annals of Clinical and Translational Neurology
Objective To examine the associations of renin–angiotensin system (RAS) inhibitor use with postmortem brain insulin signaling and neuropathology. Methods Among Religious Orders Study participants, 150 deceased and autopsied older individuals (75 with ...
Han Tong, Ana W. Capuano, Rupal I. Mehta, Ajay Sood, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis   +7 more
doaj   +1 more source

Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

New England Journal of Medicine, 2012
BACKGROUND The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the disease develops over many years.
R. Bateman, C. Xiong, T. Benzinger, A. Fagan, A. Goate, Nick C Fox, D. Marcus, N. Cairns, Xianyun Xie, Tyler M. Blazey, D. Holtzman, A. Santacruz, V. Buckles, A. Oliver, K. Moulder, P. Aisen, B. Ghetti, W. Klunk, E. McDade, R. Martins, C. Masters, R. Mayeux, J. Ringman, M. Rossor, P. Schofield, R. Sperling, S. Salloway, J. Morris   +27 more
semanticscholar   +1 more source

Serum Neurofilament Light Chain in Multiple Sclerosis: Superiority of Age‐ and BMI‐Corrected Z Scores/Percentiles Over Absolute Cutoff Values for Prediction of Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.
Maximilian Einsiedler, Aleksandra Maleska Maceski, Sofia Sandgren, Johanna Oechtering, Sabine Schaedelin, Lisa Hofer, Amar Zadic, Juan Francisco Vilchez Gomez, Lester Melie‐Garcia, Alessandro Cagol, Riccardo Galbusera, Sebastian Finkener, Patrice Lalive, Marjolaine Uginet, Stefanie Müller, Caroline Pot, Amandine Mathias, Renaud Du Pasquier, Robert Hoepner, Andrew Chan, Giulio Disanto, Chiara Zecca, Marcus D’Souza, Lars G. Hemkens, Tobias Derfuss, Özgür Yaldizli, Patrick Roth, Claudio Gobbi, David Brassat, Björn Tackenberg, Henrik Zetterberg, Tjalf Ziemssen, Heinz Wiendl, Klaus Berger, Marco Hermesdorf, Fredrik Piehl, Ludwig Kappos, Cristina Granziera, Ahmed Abdelhak, David Leppert, Eline A. J. Willemse, Pascal Benkert, Jens Kuhle, Swiss Multiple Sclerosis Cohort Study (SMSC)   +43 more
wiley   +1 more source

Treatments in Alzheimer’s disease [PDF]

Journal of Neurology, 2017
Alzheimer’s disease (AD) is the commonest cause of dementia worldwide. However, no treatment is yet available to halt or reverse the underlying pathology of established disease. Advances in the management of other common diseases and an improvement in general health have resulted in an increasingly elderly population so that the prevalence of AD is ...
Gauhar Abbas Malik, Neil Robertson
openaire   +4 more sources

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, EarlyView.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

A service‐oriented approach to clinical trial recruitment for dementia and brain health: Methods and case examples of MyAlliance for Brain Health

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Recruitment of sufficient and diverse participants into clinical research for Alzheimer's disease and related dementias remains a formidable challenge.
Eric D. Vidoni, Emma Swinford, Kelli Barton, Jaime Perales‐Puchalt, C. Michelle Niedens, Tina Lewandowski, Tiffany Schwasinger‐Schmidt, Jill Peltzer, JoEllen Wurth, Jannette Berkley‐Patton, Ryan A. Townley, W. Todd Moore, Ashley R. Shaw, Mickeal N. Key, Erica Andrade, Melissa Robinson, Susan Sprague, Aiden Bondurant, Debra Brook, Jennifer Freund, Jeffrey M. Burns   +20 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Hippocampal atrophy has limited usefulness as a diagnostic biomarker on the early onset Alzheimer's disease patients: A comparison between visual and quantitative assessment

NeuroImage: Clinical, 2019
NIA-AA diagnostic criteria include volumetric or visual rating measures of hippocampal atrophy (HA) as a diagnostic biomarker of Alzheimer's disease (AD).
Neus Falgàs, Raquel Sánchez-Valle, Núria Bargalló, Mircea Balasa, Guadalupe Fernández-Villullas, Beatriz Bosch, Jaume Olives, Adrià Tort-Merino, Anna Antonell, Cristina Muñoz-García, María León, Oriol Grau, Magdalena Castellví, Nina Coll-Padrós, Lorena Rami, Alberto Redolfi, Albert Lladó   +16 more
doaj  

Powder Metallurgy Preparation of Metastable β Ti–Cr–Ge Alloys for Medical Applications

Advanced Engineering Materials, EarlyView.
This study develops metastable β Ti–Cr–Ge alloys using powder metallurgy for biomedical implants. The Ti–10Cr–2Ge alloy exhibits superior mechanical performance with high yield strength (>1100 MPa), low Young's modulus (<85 GPa), and excellent strain hardening behavior.
Teddy Sjafrizal, Damon Kent, Ali Dehghan‐Manshadi, Matthew S. Dargusch   +3 more
wiley   +1 more source