Results 71 to 80 of about 9,230,509 (381)
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020 Introduction Abnormal brain amyloid beta (Aβ) is typically assessed in vivo using global concentrations from cerebrospinal fluid and positron emission tomography (PET). However, it is unknown whether the assessment of the topographical distribution of Aβ
Tharick A. Pascoal +14 more
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Alzheimer's Research & Therapy, 2011 The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by mitochondrial dysfunction, but the mechanisms underlying this dysfunction ...
Anne Eckert, K. Schmitt, Jürgen Götz
semanticscholar +1 more source
Alzheimer's disease and the microbiome [PDF]
Frontiers in Cellular Neuroscience, 2013 The recognition of the human microbiome (HM) as a substantial contributor to nutrition, health and disease is a relatively recent one, and currently, peerreviewed studies linking alterations in microbiota to the etiopathology of human disease are few. Emerging studies indicate that the HM may contribute to the regulation of multiple neuro-chemical and ...
Walter J. Lukiw +1 more
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Cerebrovascular stiffness and flow dynamics in the presence of amyloid and tau biomarkers
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021 Introduction This work investigated the relationship between cerebrovascular disease (CVD) markers and Alzheimer's disease (AD) biomarkers of amyloid beta deposition, and neurofibrillary tau tangles in subjects spanning the AD clinical spectrum.
Leonardo A. Rivera‐Rivera +10 more
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A deep belief network-based method to identify proteomic risk markers for Alzheimer disease [PDF]
arXiv, 2020 While a large body of research has formally identified apolipoprotein E (APOE) as a major genetic risk marker for Alzheimer disease, accumulating evidence supports the notion that other risk markers may exist. The traditional Alzheimer-specific signature analysis methods, however, have not been able to make full use of rich protein expression data ...
arxiv
Biomarkers in Alzheimer’s Disease [PDF]
Frontiers in Neurology, 2011 Alzheimer's disease (AD) is the most common form of dementia in the elderly, and it is characterized by progressive impairment in multiple cognitive domains of sufficient severity to interfere with individuals' daily living activities. Historically, the diagnosis of AD has been based on the identification of a clinical syndrome, and accuracy studies of
Mario eRiverol +2 more
openaire +4 more sources
Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiota [PDF]
arXiv, 2015 Alzheimer's disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of brain disorders, its impact on Alzheimer's disease is not known.
arxiv
2020 Alzheimer's disease facts and figures
Alzheimer's & Dementia, 2020 This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society.
semanticscholar +1 more source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2018 Introduction Less than 10% of early‐onset Alzheimer's disease (EOAD) is explained by known mutations. Methods We conducted genetic linkage analysis of 68 well‐phenotyped Caribbean Hispanic families without clear inheritance patterns or mutations in APP ...
Rong Cheng +11 more
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Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021 Introduction The decision to undergo genetic testing for familial frontotemporal dementia (fFTD) is challenging and complex. When counseling individuals, clinicians need to know what individuals understand about the type of fFTD for which they may be at ...
Bonnie Wong +5 more
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