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Diverse Roles of Ceramide in the Progression and Pathogenesis of Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, and is associated with several pathophysiological features, including cellular dysfunction, failure of neurotransmission, cognitive impairment, cell death, and other clinical ...
Md Riad Chowdhury+2 more
doaj +1 more source
Escala de Avaliação da Doença de Alzheimer – Subescala cognitiva (ADAS-Cog): Dados normativo para a população portuguesa [PDF]
Introduction: The Alzheimer’s Disease Assessment Scale – Cognitive Subscale is a brief battery developed to assess cognitive functioning in Alzheimer’s disease that encompasses the core characteristics of cognitive decline (e.g. memory, language, praxis,
Almeida, Jorge+6 more
core +2 more sources
Additional file 2: of The neuropathological diagnosis of Alzheimerâ s disease
Figure S2. Clinical Diagnoses of 227 Patients with a Pathologic Diagnosis of Pure AD. More than a third of pathologic AD cases on the Mayo Clinic Brain Bank from 2007 to 2016 were not expected to have AD. (PPTX 52 kb)
DeTure, Michael, Dickson, Dennis
openaire +1 more source
Alzheimer’s disease and the fornix [PDF]
Alzheimer's disease (AD) is the most common form of neurodegenerative dementia. Researchers have long been focused on the cortical pathology of AD, since the most important pathologic features are the senile plaques found in the cortex, and the neurofibrillary tangles and neuronal loss that begin in the entorhinal cortex and the hippocampus.
Kenichi eOishi+3 more
openaire +5 more sources
Introduction There is a 99.6% failure rate of clinical trials for drugs to treat Alzheimer's disease, likely because Alzheimer's disease (AD) patients cannot be easily identified at early stages. This study investigated machine learning approaches to use
Jack Albright+1 more
doaj +1 more source
Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
Akiyama+147 more
core +1 more source
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source
Atherosclerosis and Hippocampal Volumes in Older Adults: The Role of Age and Blood Pressure
Background Lower hippocampal volume is associated with late‐life cognitive decline and is an important, but nonspecific marker for clinical Alzheimer's dementia. Cerebrovascular disease may also be associated with hippocampal volume.
Alifiya Kapasi+7 more
doaj +1 more source
Mitochondrial links between brain aging and Alzheimer’s disease
Advancing age is a major risk factor for Alzheimer’s disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging.
Heather M. Wilkins, Russell H. Swerdlow
doaj +1 more source
Amyloid-beta peptide, oxidative stress and inflammation in Alzheimer’s disease: Potential neuroprotective effects of omega-3 polyunsaturated fatty acids [PDF]
Alzheimer’s disease is the most common form of dementia in the elderly and is a progressive neurodegenerative disorder characterised by a decline in cognitive function and also profound alterations in mood and behaviour. The pathology of the disease is
Dyall, Simon
core +3 more sources