Results 51 to 60 of about 709,465 (344)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Mitochondrial links between brain aging and Alzheimer’s disease
Translational Neurodegeneration, 2021 Advancing age is a major risk factor for Alzheimer’s disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging.
Heather M. Wilkins, Russell H. Swerdlow
doaj +1 more source
Additional file 2: of The neuropathological diagnosis of Alzheimerâ s disease
, 2019 Figure S2. Clinical Diagnoses of 227 Patients with a Pathologic Diagnosis of Pure AD. More than a third of pathologic AD cases on the Mayo Clinic Brain Bank from 2007 to 2016 were not expected to have AD. (PPTX 52 kb)
DeTure, Michael, Dickson, Dennis
openaire +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. [PDF]
, 2019 As a part of the central nervous system, the retina may reflect both physiologic processes and abnormalities related to diseases of the brain. Indeed, a concerted effort has been put forth to understand how Alzheimer's disease (AD) pathology may manifest
Honma, Patrick +2 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Relationship between afternoon napping and cognitive function in the ageing Chinese population
General Psychiatry, 2021 Background Several studies have shown that afternoon napping promotes cognitive function in the elderly; on the other hand, some studies have shown opposite results.
Wei Li +5 more
doaj +1 more source
Storying Alzheimer's Disease in Lisa Genova's Still Alice [PDF]
, 2014 Taking as its starting point the value of literary studies to work on ageing, this paper explores the contribution of literature to the discourse of ageing and illness, focussing on an illness synonymous with ageing in the cultural imagination ...
Falcus, Sarah
core
Souvenaid in the Management of Mild Cognitive Impairment: An Expert Consensus Opinion [PDF]
, 2019 Background Mild cognitive impairment (MCI) among an aging global population is a growing challenge for healthcare providers and payers. In many cases, MCI is an ominous portent for dementia.
Bertolucci, Paulo +11 more
core +3 more sources
Additional file 3: of The neuropathological diagnosis of Alzheimerâ s disease
, 2019 Figure S3. Pathologic Diagnoses in 626 Patients with Clinical Diagnosis of AD. The majority of clinical AD cases as observed in the Mayo Clinic Brain Bank from 2007 to 2016 were found to have co-pathologies. (PPTX 63 kb)
DeTure, Michael, Dickson, Dennis
openaire +1 more source