Results 1 to 10 of about 157,234 (246)
BMJ Open, 2022 Objective Preventing Alzheimer’s dementia (AD) fundamentally equates to delaying onset. Thus, we quantified associations of modifiable, psychosocial risk factors to years of delayed onset of dementia.Design Two prospective cohorts (n=2860) with negative ...
Robert S Wilson +4 more
doaj +1 more source
Epidemiological Characteristics of Dementia and Its Correlation with Multimorbidity among Residents Aged 65 and Above [PDF]
Zhongguo quanke yixue, 2023 Background In the context of aging society in China, the prevalence of Alzheimer's disease increases and multimorbidity becomes more common with years. However, the extensive investigations of Alzheimer's disease in Hunan province have not been
ZHOU Sijing, LUO Bangan, CAO Hui, ZHANG Xi, WANG Dongxin
doaj +1 more source
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022 There are conventional screening instruments for the detection of cognitive impairment, but they have a reduced ecological validity and the information they present could be biased.
G. Palacios-Navarro +3 more
doaj +1 more source
Biomedicine and Informatics Model of Alzheimer’s disease [PDF]
American Journal of Biochemistry and Biotechnology, 2007 In a perspective of biomedicine and informatics, the mechanism of Alzheimer's, senile amnesia, or other aging-associated and cognitive impairment related diseases involve four important informative processing procedures: propagation, consolidation, retrieval and cognition, In this study, we systematically model the four procedures based on published ...
Kang Cheng, Chang-Hua Zou
openaire +1 more source
Survey Based Study: Classification of Patients with Alzheimer’s Disease
Iraqi Journal of Science, 2020 Neuroimaging is a description, whether in two-dimensions (2D) or three-dimensions (3D), of the structure and functions of the brain. Neuroimaging provides a valuable diagnostic tool, in which a limited approach is used to create images of the focal sensory system by medicine professionals.
Shaimaa A. Al-Majeed +1 more
openaire +2 more sources
Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
EMBO Molecular Medicine, 2020 Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how subthreshold risk loci translate into relevant disease pathways is unknown.
Annerieke Sierksma +10 more
doaj +1 more source
NeuroImage: Clinical, 2020 Introduction: Volumetric biomarkers for Alzheimer disease (AD) are attractive due to their wide availability and ease of administration, but have traditionally shown lower diagnostic accuracy than measures of neuropathological contributors to AD.
Lauren N. Koenig +16 more
doaj +1 more source
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
Neurobiology of Disease, 2008 The down-regulation of protein phosphatase 2A (PP2A) activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's disease (AD) brain. Methylation of the PP2A catalytic subunit at the L309 site can potently
Xin-Wen Zhou +6 more
doaj +1 more source
Treatment of Alzheimer's Disease with Anti-Homocysteic acid Antibody [PDF]
, 2008 Homocysteic acid (HA) may play an important role in Alzhiemer disease (AD) as we previously reported that HA induced accumulation of intraneuronal A[beta]42. In this study, we first analyzed HA levels in a mouse model of AD.
Frank M. LaFerla +3 more
core +5 more sources
Human microglial cells synthesize albumin in brain [PDF]
, 2008 Albumin has been implicated in Alzheimer's disease since it can bind to and transport amyloid beta, the causative agent; albumin is also a potent inhibitor of amyloid beta polymerization.
Bonghee Lee +9 more
core +5 more sources