Results 91 to 100 of about 9,049 (204)
Journal of Associated Medical Sciences, 2018 Backgrounds: The most common lethal mushrooms are invariably attributed to amanitas, which contain several types of lethal peptide toxins. During 2015 to 2018, the suspect in phalloides syndrome case reported to the Thai National Institute of Health ...
Sathaporn Ramchiun +8 more
doaj
Abstract 62: CD19 - a potential target for Amanitin-based ADCs
, 2017 Background ATACs (antibody-targeted Amanitin conjugates) comprise a new class of antibody-drug conjugates using amanitin as toxic payload.
Christoph Müller +5 more
core +1 more source
Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin.
, 2018 RNA polymerase II (Pol II) is the central enzyme that transcribes eukaryotic protein-coding genes to produce mRNA. The mushroom toxin α-amanitin binds Pol II and inhibits transcription at the step of RNA chain elongation.
Lucas Farnung +11 more
core +1 more source
四川大学学报. 自然科学版, 2004 利用加端PCR技术在 pGEX 1λT质粒BamHI和PstI位点间 (片段BamHI端 )加入α amanitin线性八肽碳骨架编码序列 ,再将两次连续加端PCR产物连入BamHI、PstI双酶切的pGEX 1λT载体 ,得到含α amanitin线性碳骨架编码序列的阳性重组子pGAT 1 .序列测定和结果分析显示 ,构建的融合基因相位正确 ,阅读框通读 .通过对融合基因在大肠杆菌中表达条件的优化 ,目的融合蛋白的表达量可提高 33.5 %,占总蛋白表达量的 2 8.3%.
赵建 +6 more
doaj
, 1971 α-AMANITIN, a cyclic peptide of the toadstool Amanita phalloides1,2, causes necrosis of liver and kidney cells, the first morphological lesions occurring in the nuclei3,4.
Campadelli-Fiume, G. +5 more
core +1 more source
Transdermal absorption of alpha amanitin toxin from amanita phalloides in mice
, 2012 YÖK Tez No: 340816ÖZETFARELERDE AMANİTA PHALLOİDES TOKSİNİ ALFA AMANİTİNİNDERİDEN EMİLİMİMustafa Gani SÜRMENYüksek Lisans Tezi, Farmakoloji Anabilim DalıTez danışmanı Yrd. Doç. Dr.
Sürmen, Mustafa Gani
core
Concise Chemoenzymatic Synthesis of 4,5-Dihydroxyisoleucine Fragment of α-Amanitin
The ability of α-amanitin to potently inhibit RNA polymerase II (RNAP II) has elicited further research into its use as a novel payload for antibody-drug conjugates.
Hans, Renata, Tsung-Han, Chao
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Analysis of the Toxins of Amanitin-Containing Mushrooms
Zeitschrift für Naturforschung C, 1974 Faulstich, H. +3 more
openaire +3 more sources
Chemoenzymatic Synthesis of 4,5-Dihydroxyisoleucine Fragment of α‑Amanitin
The ability of α-amanitin to potently inhibit RNA polymerase II (RNAP II) has elicited further research into its use as a novel payload for antibody-drug conjugates.
Tsung-Han Chao (3423773) +1 more
core +1 more source