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RNA Pol II inhibition activates cell death independently from the loss of transcription. [PDF]
CellHarper NW +5 more
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AMA-Positive Cholestasis in Celiac Disease: Why Primary Biliary Cholangitis Should Not Be Excluded by Biopsy Alone. [PDF]
Clin Case RepAwan MA.
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Amanita phalloides-Associated Liver Failure: Molecular Mechanisms and Management. [PDF]
Int J Mol SciKayes T, Ho V.
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Mechanism and treatment of α-amanitin poisoning
Archives of Toxicology, 2022Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symptomatic and supportive therapy. The pathogenesis of α-amanitin mainly includes: α-amanitin can inhibit the activity of RNA polymeraseII in the ...
Guobing Chen, Ruifei Shao, Deyuan Ning
exaly +3 more sources
Experientia, 1991
Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far.
T, Wieland, H, Faulstich
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Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far.
T, Wieland, H, Faulstich
openaire +2 more sources
Conformation and toxicity of amanitins
Experientia, 1973Die Cottoneffekte der Amanitine konnten dem Indolteil bzw. den Amidgruppen des Molekuhls zugeordnet werden. Das untoxische Amanullin besitzt die gleiche Konformation wie die toxischen Peptide, das untoxische Aldoamanitin dagegen eine andere.
Faulstich, H. +3 more
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Analytical Biochemistry, 1985
A high-performance liquid chromatographic assay of alpha-amanitin and beta-amanitin in human serum, urine, or stomach washings is described. Sample preparation involves a chemical step with deproteinization and organic solvent treatment, and a selective cleanup and concentration step on reversed-phase prepacked cartridges.
F Flesch, A Jaeger
exaly +3 more sources
A high-performance liquid chromatographic assay of alpha-amanitin and beta-amanitin in human serum, urine, or stomach washings is described. Sample preparation involves a chemical step with deproteinization and organic solvent treatment, and a selective cleanup and concentration step on reversed-phase prepacked cartridges.
F Flesch, A Jaeger
exaly +3 more sources
Food Chemistry, 2022
Amanitin (AMA) is responsible for human fatalities after ingestion of poisonous mushrooms, thus, a rapid and accurate detection method is urgently needed. Here, gold nanoparticle-based immunosensor with monoclonal antibody against AMA was constructed for rapid detection of alpha- and beta-amanitin (α- and β-AMA) in mushroom, serum and urine samples ...
Shengyang, Zhou +8 more
openaire +2 more sources
Amanitin (AMA) is responsible for human fatalities after ingestion of poisonous mushrooms, thus, a rapid and accurate detection method is urgently needed. Here, gold nanoparticle-based immunosensor with monoclonal antibody against AMA was constructed for rapid detection of alpha- and beta-amanitin (α- and β-AMA) in mushroom, serum and urine samples ...
Shengyang, Zhou +8 more
openaire +2 more sources