Results 121 to 130 of about 8,493 (176)
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Archives of Virology, 1978
The advances in virus research made possible by the use of amanitins are reported; they include i) determination of the genetic source (i.e. cellular or viral) of the RNA polymerase transcribing the viral genome, and ii) mechanism of virus-induced shut-off of host RNA synthesis.
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The advances in virus research made possible by the use of amanitins are reported; they include i) determination of the genetic source (i.e. cellular or viral) of the RNA polymerase transcribing the viral genome, and ii) mechanism of virus-induced shut-off of host RNA synthesis.
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Synthesis of a Cytotoxic Amanitin for Biorthogonal Conjugation
ChemBioChem, 2015AbstractAlpha‐amanitin is an exceedingly toxic, naturally occurring, bicyclic octapeptide that inhibits RNA polymerase and results in cellular and organismal death. Here we report the straightforward synthesis of an amanitin analogue that exhibited near‐native toxicity.
Kaveh Matinkhoo +2 more
exaly +4 more sources
Amanitin binding to RNA polymerase II in α-amanitin-resistant rat myoblast mutants
Journal of Molecular Biology, 1977A series of independent α-amanitin-resistant (Ama R ) mutants have been isolated from diploid and tetraploid strains of L6 rat myoblast cells. With one exception, these mutants contain both α-amanitin-sensitive wild-type and α-amanitin-resistant mutant RNA polymerase II activities.
M M, Crerar +5 more
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Abstract 735: SAR of amanitin and optimization of linker-amanitin derivatives for solid tumors
Cancer Research, 2018Abstract Background: ATACs (Antibody Targeted Amanitin Conjugates) comprise a new class of antibody-drug conjugates using amanitin as toxic payload. Amanitin binds to the eukaryotic RNA pol II and thereby inhibits the cellular transcription process at very low concentrations.
Michael Kulke +7 more
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Production of antibodies to amanitins as the basis for their radioimmunoassay
Experientia, 1975The production of antibodies against amanitins is described. By means of these antibodies, a radioimmunoassay was developed which allows detection of as little as 0.5 ng of amanitins in 1 ml of serum. By this method, the clearance of alpha-amanitin from the blood of poisoned mice was measured.
L, Fiume +3 more
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Viroid replication is inhibited by α-amanitin
Nature, 1979VIROIDS are infectious single-stranded circular RNA molecules1 which cause disease in higher Plants. Although the complete molecular structure of one viroid has recently been established2, the mechanism of viroid replication and patho-genesis is still unknown.
H P, Mühlbach, H L, Sänger
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1975
So far, most experimental investigations concerning amanitin poisoning have been done in the mouse or in the rat. In order to obtain conditions which could be better compared to human intoxication, we chose the dog for experiments. Among the amatoxins available, there are two compounds, which can be radioactively labelled: 14[C]O-methyl-γ-amanitin and ...
Faulstich, H., Fauser, U.
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So far, most experimental investigations concerning amanitin poisoning have been done in the mouse or in the rat. In order to obtain conditions which could be better compared to human intoxication, we chose the dog for experiments. Among the amatoxins available, there are two compounds, which can be radioactively labelled: 14[C]O-methyl-γ-amanitin and ...
Faulstich, H., Fauser, U.
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Total Synthesis of α‐ and β‐Amanitin
Angewandte Chemie International Edition, 2020Abstractα‐Amanitin and related amatoxins have been studied for more than six decades mostly by isolation from death cap mushrooms. The total synthesis, however, remained challenging due to unique structural features. α‐Amanitin is a potent inhibitor of RNA polymerase II. Interrupting the basic transcription processes of eukaryotes leads to apoptosis of
Christian Lutz +4 more
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Comment on: amanitin intoxication
Clinical Toxicology, 2023Cellier, Morgane +6 more
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Comment on: Amanitin intoxication
Clinical Toxicology, 2022Brent A. Neuschwander-Tetri +1 more
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