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Pathways of Resistance: Modern Multiple Myeloma Therapies and Overcoming Reliance on Genomic Integrity. [PDF]
Int J Mol SciTaritsa I, Fossel E.
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PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA. [PDF]
Cancer ResQi Z +11 more
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Cohesin forms fountains at active enhancers in C. elegans. [PDF]
Nat CommunLüthi BN +12 more
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Synthesis of a Cytotoxic Amanitin for Biorthogonal Conjugation
ChemBioChem, 2015 AbstractAlpha‐amanitin is an exceedingly toxic, naturally occurring, bicyclic octapeptide that inhibits RNA polymerase and results in cellular and organismal death. Here we report the straightforward synthesis of an amanitin analogue that exhibited near‐native toxicity.
Jonathan P May +2 more
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Mechanism and treatment of α-amanitin poisoning
Archives of Toxicology, 2022Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symptomatic and supportive therapy. The pathogenesis of α-amanitin mainly includes: α-amanitin can inhibit the activity of RNA polymeraseII in the ...
Guobing Chen, Chen Guobing
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, 1975 So far, most experimental investigations concerning amanitin poisoning have been done in the mouse or in the rat. In order to obtain conditions which could be better compared to human intoxication, we chose the dog for experiments. Among the amatoxins available, there are two compounds, which can be radioactively labelled: 14[C]O-methyl-γ-amanitin and ...
Faulstich, H., Fauser, U.
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Analytical Biochemistry, 1985
A high-performance liquid chromatographic assay of alpha-amanitin and beta-amanitin in human serum, urine, or stomach washings is described. Sample preparation involves a chemical step with deproteinization and organic solvent treatment, and a selective cleanup and concentration step on reversed-phase prepacked cartridges.
F Jehl
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A high-performance liquid chromatographic assay of alpha-amanitin and beta-amanitin in human serum, urine, or stomach washings is described. Sample preparation involves a chemical step with deproteinization and organic solvent treatment, and a selective cleanup and concentration step on reversed-phase prepacked cartridges.
F Jehl
exaly +3 more sources
Production of high purity beta amanitin
, 2012 Amaç: Beta amanitin nadiren bilimsel araştırmalarda kullanılmakta ve kullanımı gün geçtikçeartmaktadır. Piyasada bu ürün %90 saflıkta ticari olarak satılmaktadır. Bu araştırmada yükseksaflıkta beta amanitin üretme yöntemi tanımlanmıştır.Yöntem: Saflaştırma işlemi Amanita phalloides mantarlarından ekstraksiyonla yapılmıştır.Öncelikle bu mantarlar ...
YAYKAŞLI, Kürşat Oğuz +5 more
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Experientia, 1991
Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far.
T, Wieland, H, Faulstich
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Pharmacokinetic studies have provided new insights into human Amanita poisoning, but it appears to be impossible to treat this intoxication by immunotherapy. New synthetic analogs have revealed structure-activity relationships that were unknown so far.
T, Wieland, H, Faulstich
openaire +2 more sources