Results 151 to 160 of about 9,049 (204)

Conformation and toxicity of amanitins

Experientia, 1973
Die Cottoneffekte der Amanitine konnten dem Indolteil bzw. den Amidgruppen des Molekuhls zugeordnet werden. Das untoxische Amanullin besitzt die gleiche Konformation wie die toxischen Peptide, das untoxische Aldoamanitin dagegen eine andere.
Faulstich, H., Bloching, M., Zobeley, S., Wieland, T.   +3 more
openaire   +3 more sources

Ultrasensitive paper sensor for simultaneous detection of alpha-amanitin and beta-amanitin by the production of monoclonal antibodies

Food Chemistry, 2022
Amanitin (AMA) is responsible for human fatalities after ingestion of poisonous mushrooms, thus, a rapid and accurate detection method is urgently needed. Here, gold nanoparticle-based immunosensor with monoclonal antibody against AMA was constructed for rapid detection of alpha- and beta-amanitin (α- and β-AMA) in mushroom, serum and urine samples ...
Shengyang, Zhou, Lingling, Guo, Xinxin, Xu, Shanshan, Song, Liqiang, Liu, Hua, Kuang, Yingyue, Zhu, Liguang, Xu, Chuanlai, Xu   +8 more
openaire   +2 more sources

Direct, simultaneous determination of α-amanitin, β-amanitin and phalloidine by high-performance liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis, 1985
G Caccialanza, C Gandini
exaly   +3 more sources

Amanitins in virus research

Archives of Virology, 1978
The advances in virus research made possible by the use of amanitins are reported; they include i) determination of the genetic source (i.e. cellular or viral) of the RNA polymerase transcribing the viral genome, and ii) mechanism of virus-induced shut-off of host RNA synthesis.
openaire   +2 more sources

Viroid replication is inhibited by α-amanitin

Nature, 1979
VIROIDS are infectious single-stranded circular RNA molecules1 which cause disease in higher Plants. Although the complete molecular structure of one viroid has recently been established2, the mechanism of viroid replication and patho-genesis is still unknown.
H P, Mühlbach, H L, Sänger
openaire   +2 more sources

Abstract 735: SAR of amanitin and optimization of linker-amanitin derivatives for solid tumors

Cancer Research, 2018
Abstract Background: ATACs (Antibody Targeted Amanitin Conjugates) comprise a new class of antibody-drug conjugates using amanitin as toxic payload. Amanitin binds to the eukaryotic RNA pol II and thereby inhibits the cellular transcription process at very low concentrations.
Michael Kulke, Anikó Pálfi, Christoph Müller, Werner Simon, Susanne Werner-Simon, Christian Lutz, Torsten Hechler, Andreas Pahl   +7 more
openaire   +1 more source

Amanitin binding to RNA polymerase II in α-amanitin-resistant rat myoblast mutants

Journal of Molecular Biology, 1977
A series of independent α-amanitin-resistant (Ama R ) mutants have been isolated from diploid and tetraploid strains of L6 rat myoblast cells. With one exception, these mutants contain both α-amanitin-sensitive wild-type and α-amanitin-resistant mutant RNA polymerase II activities.
M M, Crerar, S J, Andrews, E S, David, D G, Somers, J L, Mandel, M L, Pearson   +5 more
openaire   +2 more sources

α-Amanitin: Inactivation by bovine lactoperoxidase

Experientia, 1979
The principle amatoxin, alpha-amanitin, is found to be extremely sensitive toward lactoperoxidase catalyzed degradation, rather than iodination, of the indole nucleus. Extensive attenuation of inhibitor potency against eukaryotic DNA-dependent RNA polymerase II accompanies the treatment of alpha-amanitin with lactoperoxidase, iodide and hydrogen ...
P W, Morris, K M, Kelley, W G, Logas
openaire   +2 more sources

Total Synthesis of α‐ and β‐Amanitin

Angewandte Chemie International Edition, 2020
Abstractα‐Amanitin and related amatoxins have been studied for more than six decades mostly by isolation from death cap mushrooms. The total synthesis, however, remained challenging due to unique structural features. α‐Amanitin is a potent inhibitor of RNA polymerase II. Interrupting the basic transcription processes of eukaryotes leads to apoptosis of
Christian Lutz, Werner Simon, Susanne Werner‐Simon, Andreas Pahl, Christoph Müller   +4 more
openaire   +2 more sources

Antidotes to Experimental cc-Amanitin Poisoning

Nature New Biology, 1972
THE two most important toxic cyclopeptides isolated from the mushroom Amanita phalloides (death cap) are phalloidin and α-amanitin1, 2. The latter is considered to be responsible for the fatal cases of poisoning. Up to now, protection has been demonstrated either with a non-toxic chemical analogue (antamanide) isolated from the toadstool itself and ...
openaire   +2 more sources