Results 1 to 10 of about 13,861 (118)

Altered Mental Status Due to Amantadine Withdrawal: A Case Report [PDF]

Reports
Background and Clinical Significance: Withdrawal symptoms from an abrupt discontinuation or rapid dose reduction in amantadine has been documented as early as 1987. Symptoms can align with several diagnoses, including but not limited to infection, fever,
Nicole J. Asal, Elisa Piraino, Cristina Hamacher, Husam Abu Nejim   +3 more
doaj   +2 more sources

Bioavailability and Pharmacokinetics of Once-Daily Amantadine Extended-Release Tablets in Healthy Volunteers: Results from Three Randomized, Crossover, Open-Label, Phase 1 Studies

Neurology and Therapy, 2019
Introduction In February 2018, OS320—an amantadine extended-release (ER) tablet formulation with once-daily morning administration—was approved for the treatment of Parkinson’s disease and drug-induced extrapyramidal reactions in adults.
Tina deVries, Angela Dentiste, Lata Handiwala, David Jacobs   +3 more
exaly   +3 more sources

Improved survival in intensive care unit in severe COVID-19 associated with amantadine use - retrospective study

International Journal of Infectious Diseases, 2022
Objectives: Possible immunomodulatory effect of amantadine in patients treated in intensive care unit (ICU), mostly among patients with brain injuries or vascular diseases was observed in several studies.
Daniel Chober, Zenon Czajkowski, Bogusz Aksak-Wąs, Katarzyna Dalewska-Kucharczyk, Katarzyna Hołubczak, Sylwia Karasińska-Milchert, Mateusz Jaremko, Miłosz Skowron, Malwina Karasińska-Cieślak, Miłosz Parczewski   +9 more
doaj   +1 more source

Antiglycoxidative properties of amantadine – a systematic review and comprehensive in vitro study

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
An important drug used in the treatment of Parkinson’s disease is amantadine. We are the first to perform a comprehensive study based on various glycation and oxidation factors, determining the impact of amantadine on protein glycoxidation.
Miłosz Nesterowicz, Małgorzata Żendzian-Piotrowska, Jerzy Robert Ładny, Anna Zalewska, Mateusz Maciejczyk   +4 more
doaj   +1 more source

Amantadine Induced Corneal Edema in a Patient with Primary Progressive Freezing of Gait [PDF]

Journal of Movement Disorders, 2013
Amantadine is commonly used for Parkinsonism. However amantadine can induce adverse corneal reaction. Here we report a patient with primary progressive freezing of gait who had severe corneal edema associated with amantadine, which was reversible after ...
Young Eun Kim, Ji Young Yun, Hui-Jun Yang, Han-Joon Kim, Mee Kum Kim, Won Ryang Wee, Beom S. Jeon   +6 more
doaj   +1 more source

Effect of Pre-exposure Use of Amantadine on COVID-19 Infection: A Hospital-Based Cohort Study in Patients With Parkinson's Disease or Multiple Sclerosis

Frontiers in Neurology, 2021
Background: Amantadine has been proposed to inhibit E-channel conductance in reconstituted lipid bilayers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Walaa A. Kamel, Walaa A. Kamel, Mohmed I. Kamel, Almunther Alhasawi, Sameh Elmasry, Fajer AlHamdan, Jasem Y. Al-Hashel, Jasem Y. Al-Hashel   +7 more
doaj   +1 more source

Toxicity of amantadine hydrochloride on cultured bovine cornea endothelial cells

Scientific Reports, 2021
Amantadine hydrochloride (HCl) is commonly prescribed for treating influenza A virus infection and Parkinson’s disease. Recently, several studies have indicated that the use of amantadine HCl is associated with corneal edema; however, the cytotoxic ...
Po-Yen Lee, Yu-Hung Lai, Po-Len Liu, Ching-Chih Liu, Chia-Cheng Su, Fang-Yen Chiu, Wei-Chung Cheng, Shiuh-Liang Hsu, Kai-Chun Cheng, Li-Yi Chiu, Tzu-En Kao, Chia-Ching Lin, Yo-Chen Chang, Shu-Chi Wang, Chia-Yang Li   +14 more
doaj   +1 more source

Comprehensive Evidence of Carrier-Mediated Distribution of Amantadine to the Retina across the Blood–Retinal Barrier in Rats

Pharmaceutics, 2021
Amantadine, a drug used for the blockage of NMDA receptors, is well-known to exhibit neuroprotective effects. Accordingly, assessment of amantadine transport at retinal barriers could result in the application of amantadine for retinal diseases such as ...
Yusuke Shinozaki, Shin-ichi Akanuma, Yuika Mori, Yoshiyuki Kubo, Ken-ichi Hosoya   +4 more
doaj   +1 more source

Amantadine Toxicity in Apostichopus japonicus Revealed by Proteomics

Toxics, 2023
Amantadine exposure can alter biological processes in sea cucumbers, which are an economically important seafood in China. In this study, amantadine toxicity in Apostichopus japonicus was analyzed by oxidative stress and histopathological methods ...
Junqiang Zhao, Jianqiang Chen, Xiuhui Tian, Lisheng Jiang, Qingkui Cui, Yanqing Sun, Ningning Wu, Ge Liu, Yuzhu Ding, Jing Wang, Yongchun Liu, Dianfeng Han, Yingjiang Xu   +12 more
doaj   +1 more source

Myoclonus Secondary to Amantadine: Case Report and Literature Review

Clinics and Practice, 2023
The usual adverse events of amantadine are dizziness, dry mouth, and peripheral edema. Postmarketing experience has revealed abnormal movements such as tremors, involuntary muscle contractions, and gait abnormalities.
Jamir Pitton Rissardo, Ana Letícia Fornari Caprara   +1 more
doaj   +1 more source