Amantadine variant – aryl conjugates that inhibit multiple M2 mutant – amantadine resistant influenza a viruses [PDF]
European Journal of Medicinal Chemistry Reports, 2022 Influenza A viruses can cause a serious future threat due to frequent mutations. Amantadine and rimantadine drugs inhibit influenza A M2 wild-type (WT; bearing in the protein M2 proton channel serine at position-31) viruses by binding and blocking M2 WT ...
Christina Tzitzoglaki +11 more
doaj +3 more sources
Amantadine can induce intra-epithelial deposition in the cornea [PDF]
American Journal of Ophthalmology Case Reports, 2020 Purpose: Amantadine has been reported to cause various corneal complications, such as superficial punctate keratitis, corneal endothelial dysfunction, and corneal edema.
Asayo Yoshinaka +2 more
doaj +2 more sources
Amantadine in Treatment of Dysthymia—The Pilot Case Series Study
Pharmaceuticals, 2023 Dysthymia is a common chronic mood disorder in which isolated symptoms of depression persist for at least 2 years. Despite the many medications recommended for the treatment of dysthymia, no recommendations have yet been made for the treatment of ...
Marek Krzystanek +5 more
doaj +2 more sources
Right ventricular outflow tract tachycardia after an initial dose of amantadine
Türk Kardiyoloji Derneği Arşivi, 2015 Amantadine hydrochloride is an antiviral agent that is also effective in the treatment of Parkinson's disease. In the literature, cardiac arrhythmia is reported in toxic doses of amantadine, but in this paper we report a patient with right ventricular ...
Cüneyt Kocaş +3 more
doaj +2 more sources
Amantadine-induced corneal edema: A case and literature review
American Journal of Ophthalmology Case Reports, 2023 Purpose: To present a case of irreversible corneal edema after 10 years of amantadine use. A literature review was carried out to describe the clinical characteristics and outcomes of amantadine-induced corneal edema.
Antony Raharja +2 more
doaj +2 more sources
A Case Report of Severe Delirium after Amantadine Withdrawal [PDF]
Case Reports in Neurology, 2017 Amantadine is frequently used in addition to dopaminergic substances like dopamine agonists or L-Dopa in advanced Parkinson disease (PD). However, adverse effects like hallucinations limit its use.
Franz Marxreiter +3 more
doaj +2 more sources
Virology Journal, 2010 Hepatitis A virus (HAV) causes acute hepatitis and sometimes leads to fulminant hepatitis. Amantadine is a tricyclic symmetric amine that inhibits the replication of many DNA and RNA viruses.
Yang Lingli +8 more
doaj +2 more sources
Persistent Amotivation After Cannabis-Related Psychosis: Diagnostic Challenges and Clinical Course With Electroconvulsive Therapy: A Case Report. [PDF]
Neuropsychopharmacol RepClinically significant amotivation persisted after improvement of cannabis‐related psychotic symptoms. Following ECT, motivation, activity, and daily functioning improved markedly, suggesting that ECT may represent a potential treatment option for severe, persistent amotivation following cannabis‐related psychosis.
Kitano Y +5 more
europepmc +2 more sources
Amantadine Variant - Aryl Conjugates that Inhibit Multiple Amantadine Resistant M2 Mutant Influenza A Viruses [PDF]
, 2021 One challenge facing anti-influenza drug development is the heterogeneity of the circulating influenza A viruses, which comprise several strains with variable susceptibility to antiviral drugs.
Antonios, Kolocouris +9 more
core +2 more sources
Amantadine Variants Activity Against Multiple Influenza A Viruses [PDF]
, 2021 Future pandemic influenza necessitates the development of new drugs against the current circulating, amantadine and rimantadine drugs resistant, influenza A M2 S31N viruses.
Μarianna , Stampolaki +18 more
core +2 more sources