Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity [PDF]
Parasites & Vectors, 2020 Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected disease that affects ~7 million people worldwide. Development of new drugs to treat the infection remains a priority since those currently available have frequent side ...
Nieves Martinez-Peinado +6 more
doaj +7 more sources
Phenolic Acids and Amaryllidaceae Alkaloids Profiles in Leucojum aestivum L. In Vitro Plants Grown under Different Light Conditions [PDF]
Molecules, 2023 Light-emitting diodes (LEDs) have emerged as efficient light sources for promoting in vitro plant growth and primary and secondary metabolite biosynthesis. This study investigated the effects of blue, red, and white-red LED lights on plant biomass growth,
Emilia Morańska +7 more
doaj +2 more sources
Two New Alkaloids from Narcissus serotinus L. [PDF]
Molecules, 2010 The Amaryllidaceae family is well known for the presence of an exclusive group of alkaloids with a wide range of biological activities. Narcissus serotinus L.
Francesc Viladomat +6 more
doaj +4 more sources
Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase [PDF]
Biomolecules, 2020 Thirteen known (1–12 and 16) and three previously undescribed Amaryllidaceae alkaloids of belladine structural type, named carltonine A-C (13–15), were isolated from bulbs of Narcissus pseudonarcissus cv.
Abdullah Al Mamun +10 more
doaj +2 more sources
Journal of Pharmacy and Bioallied Sciences, 2018 Background: Plants of the Amaryllidaceae family have been under intense scrutiny for the presence of a couple of alkaloidal secondary metabolites with endued cytotoxic activity, such as pancratistatin (1), 7-deoxypancratistatin (2), narciclasine (3), 7 ...
Bashir A Yousef +4 more
doaj +2 more sources
Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids [PDF]
Molecules, 2015 The antiproliferative activity of a set of seven natural Amaryllidaceae alkaloids and 32 derivatives against four cancer cell lines (A2780, SW1573, T47-D and WiDr) was determined.
Juan C. Cedrón +4 more
doaj +2 more sources
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors [PDF]
Molecules, 2018 Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism.
Daniela Hulcová +9 more
doaj +2 more sources
Alkaloid Profile Characterisation and Bioactivity Evaluation of Bolivian Hippeastrum Species (Amaryllidaceae) as Cholinesterase Inhibitors [PDF]
LifeAmaryllidaceae alkaloids from the Amaryllidoideae subfamily exhibit broad pharmacological activities, including neuroprotection and anticancer effects. Galanthamine is a key compound for Alzheimer’s therapy. The Hippeastrum genus, particularly in Bolivia,
María Lenny Rodríguez-Escobar +7 more
doaj +2 more sources
N-oxide alkaloids from Crinum amabile (Amaryllidaceae) [PDF]
Molecules, 2018 Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities.
Luciana R. Tallini +6 more
doaj +6 more sources
Elucidating the enzyme network driving Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum. [PDF]
Plant Biotechnol JSchematic representation of Amaryllidaceae alkaloid biosynthesis in Leucojum aestivum. Norbelladine synthase (LaNBS) and noroxomaritidine/norcraugsodine reductase (LaNRII) catalyze the condensation of tyramine and 3,4‐dihydroxybenzaldehyde to form norbelladine, which is subsequently O‐methylated by norbelladine‐4′‐O‐methyltransferase (LaN4′OMT ...
Lamichhane B +6 more
europepmc +2 more sources