Molecules, 2012 Sorafenib is a relatively new cytostatic drug approved for the treatment of renal cell and hepatocellular carcinoma. In this report we describe the synthesis of sorafenib derivatives 4a–e which differ from sorafenib in their amide part.
Branka Zorc +8 more
doaj +1 more source
Degradation of epoxy coatings under gamma irradiation [PDF]
, 2013 Epoxy networks based on Diglycidyl ether of bisphenol A (DGEBA) and cured with Jeffamines (POPA) or polyamidoamine (PAA) were gamma irradiated at 25 1C in air. Dose rates of 50, 200 or 2000 Gy h- 1 for doses up 100 kGy were used.
DJOUANI, Fatma +4 more
core +6 more sources
Frontiers in Pharmacology, 2018 Datura metel L. is a widely used traditional herbal medicine, and withanolides and amides are the two groups of main bioactive constituents in Datura metel seeds.
Silun Xu +7 more
doaj +1 more source
The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation [PDF]
, 2011 Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3).
Attya, M. +8 more
core +3 more sources
Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand
Molecules, 2010 (S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized
Dong-Sheng Ma +4 more
doaj +1 more source
Experimental pharmacological research regarding some newly synthesized benzamides on central nervous system functions [PDF]
, 2017 Three newly synthesized benzamides by the Department of Pharmaceutical Chemistry of the Faculty of pharmacy from the University of Medicine and Pharmacy „Carol Davila” Bucharest were tested in order to determine whether these new molecules have similar ...
Chiriță, Cornel +4 more
core +4 more sources
Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum [PDF]
, 2009 Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle.
Annette N. Chiang +48 more
core +1 more source
Nature CommunicationsChiral amides are common and effective structural motifs found in many pharmaceuticals and biologically active molecules. Despite their importance, existing synthetic methods are predominantly employed for the synthesis of α-amides and β-amides.
Yang Yuan, Youcan Zhang, Xiao-Feng Wu
doaj +1 more source
Diisopropylamide and TMP turbo-grignard reagents : a structural rationale for their contrasting reactivities [PDF]
, 2010 A neutral dimeric molecule in crystal form, the diisopropylamido turbo-Grignard reagent "(iPr2N)MgCl⋅LiCl" (see structure; blue N, red O, green Mg, yellow Cl, black C) separates into several charged ate species in dynamic exchange with each other in THF ...
Armstrong, David R. +4 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source