Results 31 to 40 of about 291,669 (391)

Highly chemoselective synthesis of hindered amides via cobalt-catalyzed intermolecular oxidative hydroamidation

Nature Communications, 2020
α-Tertiary amides are of great importance for medicinal chemistry. However, they are often challenging to access through conventional methods due to reactivity and chemoselectivity issues.
Yun-Nian Yin, R. Ding, D. Ouyang, Qing Zhang, R. Zhu   +4 more
semanticscholar   +1 more source

Benzylation of N-phenyl-2-phenylacetamide under microwave irradiation [PDF]

Journal of the Serbian Chemical Society, 2008
N-Phenyl-2-phenylacetamide was alkylated with benzyl chloride in the presence of powdered potassium hydroxide under microwave irradiation in a solvent-free system. The reactions were also performed in the presence of phase-transfer catalysts.
DUSAN Z. MIJIN, MASA PRASCEVIC, SLOBODAN D. PETROVIC   +2 more
doaj   +3 more sources

Structure-Based Design, Synthesis, and Biological Evaluation of the Cage–Amide Derived Orthopox Virus Replication Inhibitors

Viruses, 2022
Despite the fact that the variola virus is considered eradicated, the search for new small molecules with activity against orthopoxviruses remains an important task, especially in the context of recent outbreaks of monkeypox.
Evgenii S. Mozhaitsev, Evgeniy V. Suslov, Daria A. Rastrepaeva, Olga I. Yarovaya, Sophia S. Borisevich, Edward M. Khamitov, Dmitry S. Kolybalov, Sergey G. Arkhipov, Nikolai I. Bormotov, Larisa N. Shishkina, Olga A. Serova, Roman V. Brunilin, Andrey A. Vernigora, Maxim B. Nawrozkij, Alexander P. Agafonov, Rinat A. Maksyutov, Konstantin P. Volcho, Nariman F. Salakhutdinov   +17 more
doaj   +1 more source

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

Molecules, 2010
(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized
Dong-Sheng Ma, Hua Zhang, Wei Wang, Lijuan Liu, Chaoyu Wang   +4 more
doaj   +1 more source

Alkylation of N-substituted-2-phenylacetamides [PDF]

Journal of the Serbian Chemical Society, 2004
Various N-substituted phenylacetamides were alkylated using different alkylating agents under neutral and basic conditions. Reactions were performed at different reaction temperatures and in various solvents. Also, a number of various catalysts were used
Mijin Dušan Ž., Mišić-Vuković Milica M., Petrović Slobodan D.   +2 more
doaj   +1 more source

Thermoresponsive poly(2-oxazoline)s, polypeptoids, and polypeptides [PDF]

, 2017
This review covers the recent advances in the emerging field of thermoresponsive polyamides or polymeric amides, i.e., poly(2-oxazoline)s, polypeptoids, and polypeptides, with a specific focus on structure-thermoresponsive property relationships, self ...
Hoogenboom, Richard, Schlaad, Helmut
core   +2 more sources

Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals

Angewandte Chemie, 2018
The selective functionalization of C(sp3)−H bonds at distal positions to functional groups is a challenging task in synthetic chemistry. Reported here is a photoinduced radical cascade strategy for the divergent functionalization of amides and protected ...
Sara P. Morcillo, Elizabeth M Dauncey, J. Kim, James J. Douglas, Nadeem S. Sheikh, Daniele Leonori   +5 more
semanticscholar   +1 more source

Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides [PDF]

, 2002
The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in ...
Coull, Jason J., Dervan, Peter B., He, Guocheng, Margolis, David M., Melander, Christian, Rucker, Victor C.   +5 more
core   +1 more source

Nickel-Catalyzed 1,2-Diarylation of Simple Alkenyl Amides.

Journal of the American Chemical Society, 2018
A nickel-catalyzed conjunctive cross-coupling of simple alkenyl amides with aryl iodides and aryl boronic esters is reported. The reaction is enabled by an electron-deficient olefin (EDO) ligand, dimethyl fumarate, and delivers the desired 1,2-diarylated
J. Derosa, Roman Kleinmans, V. Tran, Malkanthi K. Karunananda, S. Wisniewski, Martin D. Eastgate, K. Engle   +6 more
semanticscholar   +1 more source

Chemodivergent transformations of amides using gem-diborylalkanes as pro-nucleophiles

Nature Communications, 2020
Amides are versatile synthetic building blocks and their selective transformations into highly valuable functionalities are much desirable in the chemical world.
Wei Sun, Lu Wang, Yue Hu, Xudong Wu, C. Xia, Chao Liu   +5 more
semanticscholar   +1 more source