Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]
, 2017 In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc +6 more
core +1 more source
Coordination chemistry to palladium(II) of pyridylbenzamidine ligands and the related reactivity with ethylene [PDF]
, 2015 The coordination chemistry to palladium of three pyridylbenzamidines (N-N') was investigated in detail. The studied pyridylbenzamidines are featured by the bulky 2,6-diisopropylphenyl substituent at the azomethine nitrogen atom of the amidine unit, and ...
Demitri, Nicola +5 more
core +1 more source
Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines [PDF]
, 2019 The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products.
Arachchige, Pandula T. Kirinde +1 more
core +3 more sources
Study of the Differential Activity of Thrombin Inhibitors Using Docking, QSAR, Molecular Dynamics, and MM-GBSA [PDF]
, 2015 Indexación: Web of Science; Scopus.Non-peptidic thrombin inhibitors (TIs; 177 compounds) with diverse groups at motifs P1 (such as oxyguanidine, amidinohydrazone, amidine, amidinopiperidine), P2 (such as cyano-fluorophenylacetamide, 2-(2-chloro-6 ...
Caballero, J. +2 more
core +8 more sources
Synthesis and Reactivity of Ynamine Amidines
CHIMIA, 1976 Ynamine amidines can be synthesized from the 1,3-dichlorotrimethine cyanine and primary amines. Ammonia affords the reactive ynamine amidine having a free imino group. This compound cyclises readily with carbon dioxide and phenylisocyanate.
B. Caillaux +4 more
doaj +1 more source
A straightforward synthesis of indazolo[3,2-a]isoquinolin-6-amines [PDF]
, 2013 4-Substituted 1-bromoisoquinolin-3-amines were subjected to Suzuki coupling with o-nitrophenylboronic acid to yield 1-(2-nitrophenyl) isoquinolinamines, which participated in Cadogan cyclization with triethyl phosphite under microwave irradiation in a ...
Balog, József +2 more
core +1 more source
N-azinylpyridinium N-aminides: tandem reactions with alpha-halocarbonyl derivatives and analogs [PDF]
, 2000 Pyridinium-N-(2´-pyridyl)aminide was reacted with different α-halocarbonyl derivatives and related compounds. The method allows an easy preparation of several heterocyclic building blocks, all including the 2-aminopyridine moietyAuthor wish to thank C.I ...
Burgos García, Carolina +3 more
core +2 more sources
Regiochemistry of cyclocondensation reactions in the synthesis of polyazaheterocycles
Beilstein Journal of Organic Chemistry, 2017 The syntheses of several polyazaheterocycles are demonstrated. The cyclocondensation reactions between β-enaminodiketones [CCl3C(O)C(=CNMe2)C(O)-CO2Et] and aromatic amidines resulted in glyoxalate-substituted pyrido[1,2-a]pyrimidinone, thiazolo[3,2-a ...
Patrick T. Campos +10 more
doaj +1 more source
Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution
Molecules, 2021 We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions.
András Gy. Németh +5 more
doaj +1 more source
Nitrogen-bound diazeniumdiolated amidines [PDF]
Chemical Communications, 2010 In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs.
Debanjan, Biswas +3 more
openaire +2 more sources