Results 41 to 50 of about 105,820 (326)

Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson’s disease

Scientific Reports, 2019
Parkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. A characteristic pathological feature of PD is cytoplasmic accumulation of α-synuclein (SNCA) protein.
T. Uehara, C. Choong, M. Nakamori, H. Hayakawa, Kumiko Nishiyama, Yuuya Kasahara, K. Baba, T. Nagata, T. Yokota, H. Tsuda, S. Obika, H. Mochizuki   +11 more
semanticscholar   +1 more source

Forging Fluorine-Containing Quaternary Stereocenters by a Light-Driven Organocatalytic Aldol Desymmetrization Process [PDF]

, 2017
Reported herein is a light-triggered organocatalytic strategy for the desymmetrization of achiral 2-fluoro-substi- tuted cyclopentane-1,3-diketones.
Ametamey, Balaraman, Banik, Beeson, Borissov, Brak, Brimioulle, Brunet, Dell'Amico, Dell'Amico, Eagan, Eder, Erb, Ford, Hajos, Hamashima, Hepburn, Hintermann, Ishimaru, Jeschke, Jiang, Kalow, Kalow, Katcher, Katcher, Klán, Kwiatkowski, Lozano, Ma, Marigo, Müller, Nakamura, O'Hagan, Partridge, Prakash, Prévost, Purser, Rauniyar, Reisman, Saadi, Sammes, Steiner, Taylor, Woerly, Yang, Yang, Yang, Zeng, Zhu, Zuend   +49 more
core   +2 more sources

GH3 Auxin-Amido Synthetases Alter the Ratio of Indole-3-Acetic Acid and Phenylacetic Acid in Arabidopsis

Plant and Cell Physiology, 2019
Auxin is the first discovered plant hormone and is essential for many aspects of plant growth and development. Indole-3-acetic acid (IAA) is the main auxin and plays pivotal roles in intercellular communication through polar auxin transport. Phenylacetic
Yuki Aoi, Keita Tanaka, S. D. Cook, Ken-ichiro Hayashi, Hiroyuki Kasahara   +4 more
semanticscholar   +1 more source

Sites of Biosynthesis of Outer and Inner Membrane Proteins of Neurospora crassa Mitochondria [PDF]

, 1970
Outer and inner membranes of Neurospora crassa mitochondria were separated by the combined swelling, shrinking, sonication procedure. Membranes were characterized by electron microscopy and by marker enzyme activities.
Aasen A. J., Arrigoni O., Beattie D. S., Beattie D. S., Beisenherz G., Cassady W. E., Goodwin T. W., Harding R. W., Hawley E. S., Neupert W., Parsons D., Schnaitman G., Schott H.-H., Vogel H. J., Weiss H.   +14 more
core   +1 more source

Dinuclear Rhodium and Iridium Complexes with Mixed Amido/Methoxo and Amido/Hydroxo Bridges

Inorganic Chemistry, 2002
The reactions of [[M(mu-OMe)(cod)](2)] (M = Rh, Ir; cod = 1,5- cyclooctadiene) with p-tolylamine, alpha-naphthylamine, and p-nitroaniline gave complexes with mixed-bridging ligands, [[M(cod)](2)(mu-NHAr)(mu-OMe)]. Similarly, the related complexes [[Rh(cod)](2)(mu-NHAr)(mu-OH)] were prepared from the reactions of [[Rh(mu-OH)(cod)](2)] with p-tolylamine,
Fernando J. Lahoz, Marta Bordonaba, José A. López, Luis A. Oro, Miguel A. Ciriano, Cristina Tejel   +5 more
openaire   +4 more sources

Imidazolium‐Derived Porous Organic Polymer as Robust Platform for Rhodium‐Catalyzed N2O Hydrogenation and Alcohol Oxygenation

Angewandte Chemie, EarlyView.
A porous NHC‐polymer with large surface area anchors Rh amide sites to yield a stable and highly active catalyst for efficient hydrogenation of N2O and selective alcohol dehydrogenation, outperforming molecular analogues. Spatially arranged NHC sites prevent Rh deactivation and leaching, enabling sustainable conversion of a climate‐relevant gas into ...
Sven Thomas Nappen, Veit Dippold, Darosch Asgari, Sarah Vogl, Hüseyin Küçükkeçeci, Arne Thomas, Monica Trincado, Hansjörg Grützmacher   +7 more
wiley   +2 more sources

Silylative Amide to Nitrile Conversion Mediated by Simple Lanthanide–Organoamides: Scope and Mechanism

Angewandte Chemie, EarlyView.
Described here is a LaNTMS mediated silylative conversion of primary amides to nitriles under neat reaction conditions. The reaction is highly efficient and selective under such solventless conditions, where all materials are commercially available, demonstrating the robustness and potential of lanthanide heteroatom catalysis.
Zhiyu Feng, Qingheng Lai, Yuang Wang, Alessandro Motta, Yosi Kratish, Tobin J. Marks   +5 more
wiley   +2 more sources

Enhancement of developmental defects in the boron‐deficient maize mutant tassel‐less1 by reduced auxin levels

Journal of Plant Nutrition and Soil Science, EarlyView., 2023
Abstract Background Plant responses to deficiencies of the micronutrient boron are diverse and go beyond the well‐characterized function of boron in cell wall crosslinking. To explain these phenotypic discrepancies, hypotheses about interactions of boron with various phytohormones have been proposed, particularly auxin.
Michaela S. Matthes, Norman B. Best, Janlo M. Robil, Paula McSteen   +3 more
wiley   +1 more source

Luminescent Platinum(II) Complexes of N^N-^N Amido Ligands with Benzannulated N-Heterocyclic Donor Arms: Quinolines Offer Unexpectedly Deeper Red Phosphorescence than Phenanthridines.

Inorganic Chemistry, 2019
A platform for investigating the impact of π-extension in benzannulated, anionic pincer-type N^N-^N-coordinating amido ligands and their Pt(II) complexes is presented. Based on bis(8-quinolinyl)amine, symmetric and asymmetric proligands bearing quinoline
Pavan Mandapati, Jason D. Braun, Charles Killeen, Rebecca L. Davis, J. A. G. Williams, David E. Herbert   +5 more
semanticscholar   +1 more source

NIR‐Activatable, Sequence‐Specific Metal‐Nucleic Acid Scaffolds for Responsive Uncaging

Angewandte Chemie, EarlyView.
We demonstrate that long‐range nucleic acid‐mediated electron transfer can drive Pt(IV) photoreduction, establishing a new class of metal‐nucleic acid scaffolds capable of “responsive uncaging,” where hybridization with target DNA or miRNA directly triggers payload release under NIR irradiation.
Arpit Sharma, Man Kshetri, Deepak Karna, Md Al Amin, Shirin Akter, Hanbin Mao, Yao‐Rong Zheng   +6 more
wiley   +2 more sources