Results 61 to 70 of about 10,587 (231)
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
Frontiers in ChemistryReAV, the inducible Class-3 L-asparaginase from the nitrogen-fixing symbiotic bacterium Rhizobium etli, is an interesting candidate for optimizing its enzymatic potential for antileukemic applications.
Kinga Pokrywka +9 more
doaj +1 more source
Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway. [PDF]
PLoS ONE, 2014 The N-end rule states that half-life of protein is determined by their N-terminal amino acid residue. N-terminal glutamine amidohydrolase (Ntaq) converts N-terminal glutamine to glutamate by eliminating the amine group and plays an essential role in the ...
Mi Seul Park +7 more
doaj +1 more source
Mechanisms of metal-dependent non-redox decarboxylases from quantum chemical calculations
Computational and Structural Biotechnology Journal, 2021 Quantum chemical calculations are today an extremely valuable tool for studying enzymatic reaction mechanisms. In this mini-review, we summarize our recent work on several metal-dependent decarboxylases, where we used the so-called cluster approach to ...
Xiang Sheng, Fahmi Himo
doaj +1 more source
Nicotinatfermentation in Eubacterium barkeri [PDF]
, 2005 Aus EcoRI- und BamHI/BglII-Phagen-Genbänken von Eubacterium barkeri wurde mit Hilfe Digoxigenin-markierten homologen DNA-Sonden, direkter genomischer Sequenzierung und Seegene Speedwalking ein Gencluster von 23 kbp kloniert, das für die Enzyme der ...
Al Hapel, Ashraf, Buckel, W. (Prof. Dr.)
core +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT Seed defence priming is emerging as a novel, cost‐efficient and environmentally safe tool for pest management. It has been proposed as a means to uncouple the defence‐growth trade‐off in plants by enhancing defence responses with minimal fitness costs, but the mechanisms underlying this role remain elusive.
Lucia Talavera‐Mateo +5 more
wiley +1 more source
Studies on racemic triglycerides as urease enzyme inhibitors
Bangladesh Journal of PharmacologyAmidohydrolase enzymes regulate key pathways, and their dysregulation is linked to infection, immune imbalance, and metabolic dysregulation in cancer. Current inhibitors have issues of cost, environmental persistence, and toxicity.
Hamdullah Khadim Sheikh +4 more
doaj +1 more source
Molecules, 2021 Dihydroorotase (DHOase), a dimetalloenzyme containing a carbamylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase (ALLase), dihydropyrimidinase (DHPase), hydantoinase, and imidase ...
Hong-Hsiang Guan +4 more
doaj +1 more source
, 2016 The Dali server (http://ekhidna2.biocenter.helsinki.fi/dali) is a network service for comparing protein structures in 3D. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing ...
Holm, Liisa, Laakso, Laura M.
core +2 more sources
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.ABSTRACT Rapid serum paracetamol (acetaminophen) concentration measurement is essential in suspected intoxication, but centralized laboratory analyses often delay initiation of antidotal therapy. We studied the feasibility of a novel electrochemical single‐walled carbon nanotube/Nafion‐based point‐of‐care (POC) method in detecting paracetamol in 99 ...
Johanna K. Kujala +8 more
wiley +1 more source