Results 61 to 70 of about 12,409 (229)

Biochemical characterization of L-asparaginase isoforms from Rhizobium etli—the boosting effect of zinc

Frontiers in Chemistry
L-Asparaginases, divided into three structural Classes, catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. The members of Class 3, ReAIV and ReAV, encoded in the genome of the nitrogen fixing Rhizobium etli, have the same fold ...
Joanna Sliwiak, Paulina Worsztynowicz, Kinga Pokrywka, Joanna I. Loch, Marta Grzechowiak, Mariusz Jaskolski, Mariusz Jaskolski   +6 more
doaj   +1 more source

Crystal structure of human protein N-terminal glutamine amidohydrolase, an initial component of the N-end rule pathway. [PDF]

PLoS ONE, 2014
The N-end rule states that half-life of protein is determined by their N-terminal amino acid residue. N-terminal glutamine amidohydrolase (Ntaq) converts N-terminal glutamine to glutamate by eliminating the amine group and plays an essential role in the ...
Mi Seul Park, Eduard Bitto, Kyung Rok Kim, Craig A Bingman, Mitchell D Miller, Hyun-Jung Kim, Byung Woo Han, George N Phillips   +7 more
doaj   +1 more source

Mechanisms of metal-dependent non-redox decarboxylases from quantum chemical calculations

Computational and Structural Biotechnology Journal, 2021
Quantum chemical calculations are today an extremely valuable tool for studying enzymatic reaction mechanisms. In this mini-review, we summarize our recent work on several metal-dependent decarboxylases, where we used the so-called cluster approach to ...
Xiang Sheng, Fahmi Himo
doaj   +1 more source

Thiazoline-Specific Amidohydrolase PurAH Is the Gatekeeper of Bottromycin Biosynthesis.

Journal of the American Chemical Society, 2019
The ribosomally synthesized and post-translationally modified peptide (RiPP) bottromycin A2 possesses potent antimicrobial activity. Its biosynthesis involves the enzymatic formation of a macroamidine, a process previously suggested to require the ...
A. Sikandar, Laura Franz, Okke Melse, I. Antes, J. Koehnke   +4 more
semanticscholar   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Studies on racemic triglycerides as urease enzyme inhibitors

Bangladesh Journal of Pharmacology
Amidohydrolase enzymes regulate key pathways, and their dysregulation is linked to infection, immune imbalance, and metabolic dysregulation in cancer. Current inhibitors have issues of cost, environmental persistence, and toxicity.
Hamdullah Khadim Sheikh, Tanzila Arshad, Haroon Khan, Uzma Habib, Cindy Juliet Cristancho Ortiz   +4 more
doaj   +1 more source

Inactivation of anandamide signaling : A continuing Debate [PDF]

, 2010
Copyright 2011 Elsevier B.V., All rights reserved.Peer reviewedPublisher ...
Ahluwalia, Ahn, Alexander, Alexander, Beltramo, Bhave, Bifulco, Bisogno, Bisogno, Bosier, Cadas, Chen, Chuang, Clapper, Cravatt, Cravatt, Cristino, Day, De Petrocellis, De Petrocellis, De Petrocellis, Desarnaud, Deutsch, Deutsch, Devane, Devane, Di Carlo, Di Marzo, Di Marzo, Di Marzo, Egertova, Evans, Evans, Evans, Fedorova, Glaser, Guzmán, Hampson, Hanus, Harizi, Hesham Khairy, Hillard, Hillard, Hillard, Horvath, Howlett, Howlett, Iversen, Jarrahian, Jiang, Jonsson, Kaczocha, Kaczocha, Katayama, Kathuria, Khairy, Klein, Koutek, Kulkarni-Narla, Liu, Long, Maccarrone, Malcher-Lopes, Matsuda, McFarland, Mechoulam, Mechoulam, Mechoulam, Mechoulam, Miller, Moore, Mulder, Munro, Numazaki, Okamoto, Ortar, Pertwee, Piomelli, Poling, Porter, Premkumar, Randall, Schlosburg, Schmid, Simon, Stella, Stremmel, Sun, Sun, Sánchez, Thomas, Thors, Tian, Tsou, Tsuboi, Ueda, Ueda, Van den Bossche, Van Der Stelt, Wael E. Houssen, Walker, Weber, Wenger, Wood, Woodward, Yu, Zygmunt   +106 more
core   +3 more sources

Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.

ACS Infectious Diseases, 2017
Photopharmacological agents exhibit light-dependent biological activity and may have potential in the development of new antimicrobial agents/modalities.
Claire E. Weston, Andreas Krämer, Félix Colin, Özkan Yildiz, M. Baud, F. Meyer‐Almes, M. Fuchter   +6 more
semanticscholar   +1 more source

The gut microbiome promotes the growth performance of black soldier fly larvae by detoxifying uric acid

iMetaOmics, EarlyView.
This study demonstrates the detrimental effects of exogenous uric acid (UA) on the growth of black soldier fly (BSF) larvae, highlighting the role of gut microbiota in UA degradation. We isolated UA‐degrading bacterial strains associated with BSF, including Enterococcus faecalis AHAU24.
Xiaowen Ji, Shaojie Zhou, Wenwen Chen, Bin Cao, Jingjing Zhuang, Sheng Zhang, Bingshuo Han, Benping Yang, Shuxiang Zhang, Yanfeng Xue, Jibin Zhang, Yinglao Zhang, Wei Liu   +12 more
wiley   +1 more source

Structural Analysis of Saccharomyces cerevisiae Dihydroorotase Reveals Molecular Insights into the Tetramerization Mechanism

Molecules, 2021
Dihydroorotase (DHOase), a dimetalloenzyme containing a carbamylated lysine within the active site, is a member of the cyclic amidohydrolase family, which also includes allantoinase (ALLase), dihydropyrimidinase (DHPase), hydantoinase, and imidase ...
Hong-Hsiang Guan, Yen-Hua Huang, En-Shyh Lin, Chun-Jung Chen, Cheng-Yang Huang   +4 more
doaj   +1 more source