Results 81 to 90 of about 12,409 (229)

Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway

Biomolecules, 2020
The N-degron pathway is a proteolytic system in which a single N-terminal amino acid acts as a determinant of protein degradation. Especially, degradation signaling of N-terminal asparagine (Nt-Asn) in eukaryotes is initiated from its deamidation by N ...
Joon Sung Park, Jae-Young Lee, Yen Thi Kim Nguyen, Nae-Won Kang, Eun Kyung Oh, Dong Man Jang, Hyun-Jung Kim, Dae-Duk Kim, Byung Woo Han   +8 more
doaj   +1 more source

A NIR fluorescent probe for Vanin-1 and its applications in imaging, kidney injury diagnosis, and the development of inhibitor

Acta Pharmaceutica Sinica B, 2022
Vanin-1 is an amidohydrolase that catalyses the conversion of pantetheine into the amino-thiol cysteamine and pantothenic acid (coenzyme A precursor), which plays a vital role in multiple physiological and pathological processes. In this study, an enzyme-
Zhenhao Tian, Fei Yan, Xiangge Tian, Lei Feng, Jingnan Cui, Sa Deng, Baojing Zhang, Tian Xie, Shanshan Huang, Xiaochi Ma   +9 more
doaj   +1 more source

A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

eLife, 2017
The N-end rule pathway is an evolutionarily conserved proteolytic system that degrades proteins containing N-terminal degradation signals called N-degrons, and has emerged as a key regulator of various processes.
Zhaowei Wang, Xiaoling Xia, Xueli Yang, Xueyi Zhang, Yongxiang Liu, Di Wu, Yuan Fang, Yujie Liu, Jiuyue Xu, Yang Qiu, Xi Zhou   +10 more
doaj   +1 more source

SECONDARY EFFECT OF 8-AZAGUANINE ON THE INDUCED OR CONSTITUTIVE SYNTHESIS OF PENICILLINASE IN BACILLUS CEREUS. EUR 509.e [PDF]

, 1963
1. 1. During the restoration of protein synthesis caused by guanosine after inhibition by azaguanine, the differential rate of synthesis of penicillinase (penicillin amidohydrolase, EC 3.5.2.6) is much reduced. 2. 2.
Chantrenne, H., Leclercq-Calingaert, M.
core   +1 more source

Thermodynamics of ligand binding to histone deacetylase like amidohydrolase from Bordetella/Alcaligenes [PDF]

, 2014
Thermodynamic studies on ligand–protein binding have become increasingly important in the process of drug design. In combination with structural data and molecular dynamics simulations, thermodynamic studies provide relevant information about the mode of
Baud, Matthias, Fuchter, Matthew J., Meyer-Almes, Franz-Josef, Meyners, Christian   +3 more
core   +1 more source

The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily

Journal of Biological Chemistry, 2017
Strain SYK-6 of the bacterium Sphingobium sp. catabolizes lignin-derived biphenyl via a meta-cleavage pathway. In this pathway, LigY is proposed to catalyze the hydrolysis of the meta-cleavage product (MCP) 4,11-dicarboxy-8-hydroxy-9-methoxy-2-hydroxy-6 ...
E. Kuatsjah, A. Chan, M. Kobylarz, M. Murphy, L. Eltis   +4 more
semanticscholar   +1 more source

Crystal structure of Methanococcus jannaschii dihydroorotase with substrate bound

Acta Crystallographica Section F, Volume 82, Issue 1, Page 23-31, January 2026.
We present the 1.87 Å resolution structure of M. jannaschii dihydroorotase complexed with the substrate carbamoyl aspartate at room temperature. Contrary to expectations, a flexible loop which is important in catalysis and closes upon substrate binding in order to stabilize the substrate and transition state is observed in both the loop‐out and loop‐in
Jacqueline Vitali, Jay C. Nix, Haley E. Newman, Michael J. Colaneri   +3 more
wiley   +1 more source

Characterization of Jasmonoyl-Isoleucine (JA-Ile) Hormonal Catabolic Pathways in Rice upon Wounding and Salt Stress

Rice, 2019
Background Jasmonate (JA) signaling and functions have been established in rice development and response to a range of biotic or abiotic stress conditions.
Mohamed Hazman, Martin Sühnel, Sandra Schäfer, Julie Zumsteg, Agnès Lesot, Fréderic Beltran, Valentin Marquis, Laurence Herrgott, Laurence Miesch, Michael Riemann, Thierry Heitz   +10 more
doaj   +1 more source

Evaluation of a Multiplex PCR Assay for the Identification of Campylobacter jejuni and Campylobacter coli [PDF]

, 2017
Background: Campylobacter jejuni and Campylobacter coli are identified as the major causes of acute gastroenteritis in humans. Because of the fastidious nature of Campylobacters, many clinical laboratories fail to routinely culture them.
Ghorbanalizadgan, Mehdi, Haj Mahmmodi, Somayeh, Piccirillo, Alessandra, Shams, Saeed   +3 more
core   +1 more source

A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP

PLoS ONE, 2018
Cyanuric acid is a common environmental contaminant and a metabolic intermediate in the catabolism of s-triazine compounds, including atrazine and other herbicides.
Lygie Esquirol, T. Peat, M. Wilding, C. Hartley, J. Newman, C. Scott   +5 more
semanticscholar   +1 more source