Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy [PDF]
International Journal of Retina and Vitreous, 2021 Background Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20–65 years and can go undetected until vision is irreversibly lost.
David S. Boyer +5 more
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Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3 [PDF]
Open Biology, 2020 Zinc-α2-glycoprotein (ZAG) is a major plasma protein whose levels increase in chronic energy-demanding diseases and thus serves as an important clinical biomarker in the diagnosis and prognosis of the development of cachexia.
Matthias Romauch
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A randomised Phase IIa trial of amine oxidase copper-containing 3 (AOC3) inhibitor BI 1467335 in adults with non-alcoholic steatohepatitis [PDF]
Nature Communications, 2023 Non-alcoholic steatohepatitis (NASH) is a progressive, inflammatory liver disease with no approved pharmacological treatment. This Phase IIa, double-blind, placebo-controlled, multicentre trial (ClinicalTrials.gov: NCT03166735) investigated ...
Philip N. Newsome +10 more
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Amine oxidase, copper containing 3 exerts anti‑mesenchymal transformation and enhances CD4+ T‑cell recruitment to prolong survival in lung cancer. [PDF]
Oncol Rep, 2021 Lung cancer remains notorious for its poor prognosis. Despite the advent of tyrosine kinase inhibitors and immune checkpoint inhibitors, the probability of curing the disease in lung cancer patients remains low. Novel mechanisms and treatment strategies are needed to provide hope to patients.
Chang CY +10 more
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Amine Oxidase, Copper Containing 3 (Aoc3) Knockout Mice Are More Prone to DSS-induced Colitis and Colonic Tumorigenesis. [PDF]
In VivoInflammatory bowel diseases and colorectal cancer are a major cause of morbidity and mortality. Amine oxidase, copper-containing 3 (AOC3) is a critical enzyme in the physiological trafficking of leukocytes and the regulation of inflammation.
Özcan Ö, Akyol Ö, Akyol A.
europepmc +4 more sources
Pan-cancer analysis reveals AOC3 as a potential therapeutic biomarker for colorectal cancer [PDF]
Discover OncologyAmine oxidase copper containing 3 (AOC3) had been reported to play an important regulatory role in the biological functional pathways, immune microenvironment and cellular function.
Guanlong Wang +5 more
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The tree of life of copper-containing amine oxidases [PDF]
Frontiers in Plant ScienceCopper-containing amine oxidases (CuAOs) catalyze the terminal oxidation of polyamines (PAs), producing ammonium, an aminoaldehyde, and hydrogen peroxide (H2O2). Plant CuAOs are induced by stress-related hormones such as methyl-jasmonate (MeJA), abscisic
Zaibao Zhang +5 more
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Frontiers in Cardiovascular Medicine, 2022 IntroductionAmine oxidase copper containing 3 (AOC3) displays adhesion between leukocytes and endothelial cells and enzymatic functions. Given its controversial role in atherogenesis, we proposed to investigate the involvement of AOC3 in the formation of
Anna Filip +9 more
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Endothelial cell-derived SSAO can increase MLC20 phosphorylation in VSMCs
Open Life Sciences, 2021 Vascular hyporesponsiveness in the shock decompensation period is an important factor leading to death. Myosin light chain 20 (MLC20) is the main effector protein that regulates vascular reactivity.
Zhang Yuxing +5 more
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Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes. [PDF]
PLoS Biology, 2018 Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown.
Haojun Yang +9 more
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