Results 11 to 20 of about 21,738 (177)

ω‐(5‐Phenyl‐2H‐tetrazol‐2‐yl)alkyl‐substituted hydrazides and related compounds as inhibitors of amine oxidase copper containing 3 (AOC3)

Archiv der Pharmazie, 2022
AbstractAmine oxidase copper containing 3 (AOC3), also known as plasma amine oxidase, semicarbazide‐sensitive amine oxidase, or vascular adhesion protein‐1, catalyzes the oxidative deamination of primary amines to aldehydes using copper and a quinone as cofactors.
Florian Galster, Timo Pöstges, Walburga Hanekamp, Matthias Lehr   +3 more
openaire   +2 more sources

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

Biomedicines, 2021
SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRPV1 ...
Ádám István Horváth, Nikolett Szentes, Valéria Tékus, Maja Payrits, Éva Szőke, Emőke Oláh, András Garami, Eszter Fliszár-Nyúl, Miklós Poór, Cecília Sár, Tamás Kálai, Szilárd Pál, Krisztina Percze, Éva Nagyné Scholz, Tamás Mészáros, Blanka Tóth, Péter Mátyus, Zsuzsanna Helyes   +17 more
doaj   +1 more source

Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep

BMC Genomics, 2023
Background The detection of selective traits in different populations can not only reveal current mechanisms of artificial selection for breeding, but also provide new insights into phenotypic variation in new varieties and the search for genes ...
Huibin Shi, Taotao Li, Manchun Su, Huihui Wang, Qiao Li, Xia Lang, Youji Ma   +6 more
doaj   +1 more source

Cytochromes c550, c552, c1 in the electron transport network of Paracoccus denitrificans: redundant or subtly different in function? [PDF]

, 2001
Paracoccus denitrificans strains with mutations in the genes encoding the cytochrome c550, c552, or c1 and in combinations of these genes were constructed, and their growth characteristics were determined.
Ludwig, B., Oost, J., van der, Otten, M.F., Reijnders, W.N.M., Spanning, R.J.M., van, Westerhoff, H.V.   +5 more
core   +3 more sources

Potential role of NADPH-oxidase in early steps of lead-induced oxidative burst in Vicia faba roots [PDF]

, 2008
The mechanism of oxidative burst induced by lead in Vicia faba excised roots was investigated by luminol-dependent chemiluminescence. Results showed that lead triggered a rapid and dose-dependent increase in chemiluminescence production.
Cecchi, Marie, Guiresse, Agnès Maritchù, Perchet, Geoffrey-Thibault, Pinelli, Eric, Pourrut, Bertrand, Silvestre, Jérôme   +5 more
core   +3 more sources

Export of functional Streptomyces coelicolor alditol oxidase to the periplasm or cell surface of Escherichia coli and its application in whole-cell biocatalysis [PDF]

, 2009
Streptomyces coelicolor A3(2) alditol oxidase (AldO) is a soluble monomeric flavoprotein in which the flavin cofactor is covalently linked to the polypeptide chain.
AJ Driessen, BJ Feilmeier, C Filip, CA Kumamoto, CF Schierle, CM Cho, CR Raetz, D Huber, D Schmid, D Tullman-Ercek, DP Heuts, E Brickman, E Frirdich, E Vrontou, EW van Hellemond, F Forneris, FJ Mergulhao, HC Jung, J Jose, J Luirink, J Zhou, JD Thomas, JS Lee, K Nakai, L Li, M Marrichi, M Shimazu, M Shimazu, MA Turner, MJ Casadaban, MJ Casadaban, ML Wu, MW Fraaije, NG Leferink, P Samuelson, PA Lee, PH Wu, R Federico, S Cristobal, SK Yim, SM Kang, SP Graether, SY Lee, T Baba, T Bruser   +44 more
core   +10 more sources

Probing the Molecular Mechanisms in Copper Amine Oxidases by Generating Heterodimers [PDF]

, 2015
For some homodimeric copper amine oxidases (CuAO), there is suggestive evidence of differential activity at the two active sites implying potential cooperativity between the two monomers.
Best, Cai, Carter, Castellani, Chiu, Choi, Choi, Collison, De Biase, Duff, Frebort, Frébort, Gasteiger, Igarashi, Jakobsson, Janes, Janes, Juda, Kumar, Langley, Lunelli, Matsuzaki, McGuirl, Morpurgo, Mu, Mure, Mure, Murray, Ohgari, Parsons, Ruggiero, Schwartz, Shepard, Tanizawa, Vargo, Wilce, Wilmot   +36 more
core   +1 more source

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage. [PDF]

, 2019
Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pathogenic and commensal human enterobacteria.
A Collins, A Cougnoux, AO Brachmann, BR Stern, Bradley S. Moore, CA Brotherton, CA Brotherton, CM Woo, D Payros, E Buc, EP Balskus, EP Rogakou, G Cuevas-Ramos, G Sharon, HB Bode, I Cho, J Chen, JA Stubbe, JC Arthur, Jennifer Y. H. Lai, Jie Li, JK Nicholson, JP Nougayrède, KJ Humphreys, KK Khanna, KS Chaturvedi, L Zha, L Zha, LB Schultz, LC Colis, LF Povirk, M Olier, M Pitie, MI Vizcaino, MI Vizcaino, MR Wilson, MS Donia, MS Donia, MS Melvin, N Bossuet-Greif, N Bossuet-Greif, NS Guntaka, P Engel, P Tripathi, Pei-Yuan Qian, RM Bleich, RM Burger, S Borah, S Tomkovich, Shaun M. K. McKinnie, T Faïs, T Pérez-Berezo, T Secher, TC Holmes, V Bondarev, Wei-Peng Zhang, Wenjun Zhang, Wenlong Cai, X Bian, X Bian, Y Pommier, YA Chan, Z-R Li, Z-R Li, Zhong-Rui Li   +64 more
core   +1 more source

Interaction of plant amine oxidases with diaminoethers [PDF]

, 2006
Polyamines are ubiquitous compounds, which are involved in crucial physiological events including cell growth and differentiation. The catabolic oxidative degradation of polyamines is catalyzed by quinoprotein copper-containing amine oxidases (CAOs ...
Floris, G, Jarkovskaa, K, Lenobelb, R, Medda, Rosaria, Padiglia, Alessandra, Pec, P., Sebelaa, M   +6 more
core   +1 more source

Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

Arthritis Research & Therapy, 2017
Background Lysyl oxidase like-2 (LOXL2) is a copper-dependent amine oxidase. Our previous studies showed that LOXL2 is elevated during mouse fracture healing.
Weam Alshenibr, Mustafa M. Tashkandi, Saqer F. Alsaqer, Yazeed Alkheriji, Amelia Wise, Sadanand Fulzele, Pushkar Mehra, Mary B. Goldring, Louis C. Gerstenfeld, Manish V. Bais   +9 more
doaj   +1 more source