Results 71 to 80 of about 8,614,620 (399)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Amino Acid Transporters on Amino Acid Absorption, Transport and Distribution in Crops
HorticulturaeAmino acid transporters mediate amino acid transport within and between cells and are the main mediators of nitrogen distribution in plants, which is crucial for maintaining plant growth and development.
Lu Liu +6 more
doaj +1 more source
PLoS ONE, 2022 For pollinators such as bees, nectar mainly provides carbohydrates and pollen provides proteins, amino acids, and lipids to cover their nutritional needs. Here, to examine differences in pollinator resources, we compared the amino acid profiles and total
Léna Jeannerod +7 more
doaj +1 more source
Annals of Translational Medicine, 2018 Amino acids serve as key building blocks and as an energy source for cell repair, survival, regeneration and growth. Each amino acid has an amino group, a carboxylic acid, and a unique carbon structure.
Ermal Aliu, S. Kanungo, G. Arnold
semanticscholar +1 more source
Determination Of Amino Acid Composition Of Broсcoli Cabbage Protein [PDF]
, 2018 A wide range of fresh fruits and vegetables grown in different geographical areas and represented in International trade networks has changed the consumers' approaches to their choice.
Belinska, S. (Svitlana) +3 more
core +2 more sources
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Impaired amino acid uptake leads to global metabolic imbalance of Candida albicans biofilms
npj Biofilms and Microbiomes, 2022 Candida albicans biofilm maturation is accompanied by enhanced expression of amino acid acquisition genes. Three state-of-the-art omics techniques were applied to detail the importance of active amino acid uptake during biofilm development.
Bettina Böttcher +7 more
doaj +1 more source
Amino acid homeostasis and signalling in mammalian cells and organisms
Biochemical Journal, 2017 Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of essential amino acids with non-essential amino acids and the transfer of amino
S. Bröer, A. Bröer
semanticscholar +1 more source
Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]
, 1989 Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G. +5 more
core +1 more source
Protein kinase FAM20C—when subcellular localization matters
FEBS Letters, EarlyView.FAM20C is a Golgi‐resident kinase that phosphorylates proteins along the entire secretory pathway. The presence of potential FAM20C substrates in the cytoplasm or nucleus raises the question of how the kinase and its substrates encounter each other. Protein kinases achieve signaling specificity through consensus sequence recognition and subcellular ...
Francesca Noventa, Mauro Salvi
wiley +1 more source