Results 71 to 80 of about 1,713,312 (302)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Correlation between nucleotide composition and folding energy of coding sequences with special attention to wobble bases [PDF]

, 2008
Background: The secondary structure and complexity of mRNA influences its accessibility to regulatory molecules (proteins, micro-RNAs), its stability and its level of expression.
AA Komar, AA Komar, C Kimchi-Sarfaty, C Soares, C Workman, DE Draper, DJ Patterson, EG Shaper, EG Shpaer, F Pagani, GD Stormo, IM Meyer, J Duan, J Konecny, Jan C Biro, JC Biro, JC Biro, JC Biro, JC Biro, JC Biro, JD Lieb, JR Powell, JV Chamary, K Mita, K Robison, KB Nielsen, L Cartegni, L Katz, M Jia, M Kellis, M Oresic, M Oresic, M Zama, M Zuker, M Zuker, MD Ermolaeva, NR Markham, P Cortazzo, P Mukhopadhyay, S Itzkovitz, SA Shabalina, W Gu, W Gu, W Seffens, W Seffens, WC Winkler, ZE Sauna   +46 more
core   +4 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Value of eight-amino-acid matches in predicting the allergenicity status of proteins: an empirical bioinformatic investigation

Clinical and Molecular Allergy, 2009
The use of biotechnological techniques to introduce novel proteins into food crops (transgenic or GM crops) has motivated investigation into the properties of proteins that favor their potential to elicit allergic reactions.
ThirumalaiswamySekhar Arvind, Song Ping, Herman Rod A   +2 more
doaj   +1 more source

The Calbindin-D28k binding site on inositol monophosphatase may allow inhibition independent of the lithium site of action [PDF]

, 2011
Among numerous reported biochemical effects the lithium-inhibitable enzyme inositol-monophosphatase (IMPase) remains a viable target for lithium's therapeutic mechanism of action.
Amnon Hoffman, Chaim Gilon, Galila Agam, Itshak Levi, Joseph Fanous, Miriam Eisenstein, Orna Almog, Yael Askira, Yftah Talgan   +8 more
core   +1 more source

Effect of SXWS/WSXWS peptides on chemotaxis and adhesion of the macrophage-like cell line J774 [PDF]

, 2015
WSXWS motif is a conserved amino acid sequence that is present in type I cytokine receptors. This motif that can be found both in the ligand binding chains and signal transducer molecule of the receptors with different amino acids at the position “X ...
Bazan, Biró, Bordo, Foxwell, Furmanek, Gouwy, Hilton, Illyés, Kernebeck, Kishimoto, Kyte, Kügler, Kőhidai, Kőhidai, Kőhidai, Kőhidai, Liang-Takasaki, Láng, McCloskey, Meissner, Ralph, Yawata, Zhou   +22 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences

International Journal of Genomics, 2017
Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. To test the hypothesis that HIV-1 tropism extends beyond the envelope into the vpr gene, studies were performed to identify ...
Gregory C. Antell, Will Dampier, Benjamas Aiamkitsumrit, Michael R. Nonnemacher, Vanessa Pirrone, Wen Zhong, Katherine Kercher, Shendra Passic, Jean Williams, Yucheng Liu, Tony James, Jeffrey M. Jacobson, Zsofia Szep, Brian Wigdahl, Fred C. Krebs   +14 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source