Results 61 to 70 of about 92,957 (299)

Catabolism of Branched-Chain Amino Acids in Heart Failure: Insights from Genetic Models [PDF]

, 2011
Genetic defects in amino acid metabolism are major causes of newborn diseases that often lead to abnormal development and function of the central nervous system.
Yibin Wang, Ren, Shuxun, Jaunian Chen, Wang, Yibin, Sun, Haipeng, Shuxun Ren, Haipeng Sun, Gang Lu, Chen, Jaunian, Lu, Gang   +9 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Circulating Branched Chain Amino Acids and Cardiometabolic Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type ...
Keenan S. Fine, John T. Wilkins, Konrad T. Sawicki   +2 more
doaj   +1 more source

Degradation Kinetics of Branched-Chain Amino Acids in Subcritical Water [PDF]

, 2010
The degradation of branched-chain amino acids (valine, leucine, and isoleucine) in subcritical water was measured from 290 °C to 330 °C. The degradation process at any temperature obeyed first-order kinetics.
KOBAYASHI, Takashi, ADACHI, Shuji, TAKASE, Koji   +2 more
core   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Insights into Protein and Amino Acid Metabolism of Thermoanaerobacter mathranii

Fermentation
Few investigations have been carried out into the members of the genus Thermoanerobacter for protein and amino acid metabolism compared to carbohydrates, mostly due to the intense interest in bioethanol and biohydrogen in recent decades.
Sean Michael Scully, Clay A. Abraham, Johann Orlygsson   +2 more
doaj   +1 more source

Oral Administration of Branched-Chain Amino Acids Attenuates Atherosclerosis by Inhibiting the Inflammatory Response and Regulating the Gut Microbiota in ApoE-Deficient Mice

, 2022
Atherosclerosis (AS) is a chronic inflammatory disease that serves as a common pathogenic underpinning for various cardiovascular diseases. Although high circulating branched-chain amino acid (BCAA) levels may represent a risk factor for AS, it is ...
Chen, Wenxiang, Wenxiang Chen, Jun Dong, Li, Hongxia, Wenduo Zhang, Mu, Hongna, Li, Ziyun, Zhang, Ranran, Ziyun Li, Ruiyue Yang, Zhang, Wenduo, Jie Zeng, Wang, Siming, Yang, Ruiyue, Zhao, Xianghui, Dong, Jun, Siming Wang, Hongna Mu, Ranran Zhang, Xianghui Zhao, Zeng, Jie, Hongxia Li   +21 more
core   +1 more source

Branched-Chain Amino Acids and Central Fatigue [PDF]

The Journal of Nutrition, 2006
An account of the tryptophan (Trp)-5-hydroxytryptamine (5-HT)-central fatigue theory is provided and an explanation of how oral administration of BCAAs can decrease fatigue on the basis of this theory is given. The rate-limiting step in the synthesis of 5-HT is the transport of Trp across the blood-brain barrier.
Eric A, Newsholme, Eva, Blomstrand
openaire   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source