Results 81 to 90 of about 92,957 (299)

Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice.

PLoS ONE, 2014
Computational models using metabolic reconstructions for in silico simulation of metabolic disorders such as type 2 diabetes mellitus (T2DM) can provide a better understanding of disease pathophysiology and avoid high experimentation costs.
Amit Kumar, Thomas Harrelson, Nathan E Lewis, Emily J Gallagher, Derek LeRoith, Joseph Shiloach, Michael J Betenbaugh   +6 more
doaj   +1 more source

Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study.

, 2015
Aims/hypothesis: South Asian individuals have an increased risk of diabetes compared with Europeans that is unexplained by obesity and traditional or established metabolic measures.
Tillin, T, Hughes, AD, Godsland, IF, Würtz, P, McKeigue, PM, Forouhi, NG, Sattar, N, Eastwood, SV, Ala-Korpela, M, Chaturvedi, N, Wang, Q   +10 more
core  

Mixed‐Metal Promotion in a Manganese‐Molybdenum Oxynitride as Catalyst to Integrate C─C and C─N Coupling Reactions for the Direct Synthesis of Acetonitrile from Syngas and Ammonia

Advanced Materials, EarlyView.
Transition metal oxy/carbo‐nitrides show great promise as catalysts for sustainable processes. A Mn‐Mo mixed‐metal oxynitride attains remarkable performance for the direct synthesis of acetonitrile, an important commodity chemical, via sequential C─N and C─C coupling from syngas (C1) and ammonia (N1) feedstocks.
M. Elena Martínez‐Monje, Wilson Henao, Tania Rodenas, Patricia Concepción, Virginia Pérez Dieste, Alexander Missyul, Giovanni Agostini, Gonzalo Prieto   +7 more
wiley   +1 more source

Evaluation of the effects of branched chain amino acids and corn-distillers dried grains by-products on the growth performance, carcass and meat quality characteristics of pigs

, 2011
Studies were conducted to evaluate the effects of corn byproducts high-protein died distillers grain (HP-DDG), and dried distillers grain with solubles (DDGS), and branched chain amino acids (BCAA) on the growth performance and meat quality of pigs.
Rojo Gomez, Alvaro
core  

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure [PDF]

, 2016
BACKGROUND: Although metabolic reprogramming is critical in the pathogenesis of heart failure, studies to date have focused principally on fatty acid and glucose metabolism.
Prosdocimo, Domenick A, Liu, Yunxia, Sun, Haipeng, Cai, Hua, Olson, Kristine C, Wang, Zhihua, Xiao, Xinshu, Gui, Wen-Jun, Jain, Mukesh K, Jeyaraj, Darwin, Schulze, Paul Christian, Gao, Chen, Ren, Shuxun, Wang, Yibin, Ilkayeva, Olga, William, Noelle S, Lynch, Christopher, Zhou, Meiyi, Youn, Ji-Youn, Wynn, R Max, Shah, Svati, Chuang, David T, Rau, Christoph D, Newgard, Christopher B   +23 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Independent and Opposite Associations Between Branched-Chain Amino Acids and Lysophosphatidylcholines With Incident Diabetes in Thais

Metabolites, 2020
Branched-chain amino acids (BCAAs) and lysophosphatidylcholines (LPCs) have been reported to be associated with diabetes. The purpose of the present study was to investigate the relative contributions of BCAAs and LPCs to the progression of prediabetes ...
La-or Chailurkit, Nitchawat Paiyabhroma, Piyamit Sritara, Prin Vathesatogkit, Sukit Yamwong, Nisakron Thonmung, Boonsong Ongphiphadhanakul   +6 more
doaj   +1 more source

Water Permeates and Plasticizes Amorphous Carbon Dots: Unraveling the Inner Accessibility of the Nanoparticles by Glass Transition Studies

Advanced Materials, EarlyView.
The water permeability of amorphous carbon dots (CDs) is demonstrated by investigating their plasticization. Novel polyamide‐based and amorphous nanoparticles are synthesized by controlling their inner packing density. Water plasticization is evidenced by the decrease of the CDs glass transition temperature with increasing the hydration degree.
Elisa Sturabotti, Valerio Di Lisio, Lucia Cardo, Alessandro Camilli, Estela Moretón Alfonsín, Daniele Cangialosi, Amaia Iturrospe Ibarra, Arantxa Arbe, Maurizio Prato   +8 more
wiley   +1 more source

Branched-chain amino acids: The best compromise to achieve anabolism?

, 2005
Purpose of review: The anorexia-cachexia syndrome is highly prevalent in patients suffering from acute and chronic diseases, including cancer, chronic renal failure and liver cirrhosis.
Akio Inui, MUSCARITOLI, Maurizio, LAVIANO, Alessandro, Giovanni Mantovani, ROSSI FANELLI, Filippo, Isabella Preziosa, CASCINO, Antonia   +6 more
core   +1 more source

Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling

, 2020
Branched chain amino acids (BCAAs) are associated with the progression of obesity-related metabolic disorders, including T2DM and non-alcoholic fatty liver disease.
Ada Admin (8524211), Jinglong Zhang (6946253), Fuyang Zhang (8556399), Huishou Zhao (8556398), Yueyang Li (151301), Xiong Wang (384462), Yi Liu (36759), Kun Lian (2726710), Huaning Xie (8556405), Miaomiao Fan (548828), Youhu Chen (7826669), Xiaomeng Zhang (182897), Chen Lin (95910), Wenjun Yan (280087), Feng Yan (183226), Chong Huang (799290), Shan Wang (120085), Ling Tao (311499), Ling Zhang (18071), Dan Sun (140898)   +19 more
core   +1 more source